Sachith Gallolu, PhD

Experience

• 

  University of Colombo

  Oct 2011 - Jul 2012

  Teaching Assistant

  Department of Chemistry• Coordinated and supervised undergraduate biochemistry and biostatistics laboratory courses• Chemistry tutoring

• 

  UT Southwestern Medical Center

  Aug 2012 - Jul 2019

  Office of Technology Development • Assessed technologies licensed from the university by biopharmaceutical companies• Matched university-produced technologies and intellectual property to commercial products• Analyzed drug development pipelines of biopharmaceutical companies and clinical trials Department of Pharmacology• Identified novel functions of the WNK pathway in gene expression regulation• Gene editing of the WNK pathway components• Analyzed the cellular localization of epithelial sodium channel in small cell lung cancer cells• Characterized novel protein interactors of the WNK signaling pathway Department of Pharmacology• Successfully led and completed a research project on the regulation of autophagy by protein kinase WNK1• Elucidated the regulation of inward-rectifier potassium channel Kir2.3 by the WNK pathway• Mentored a first year graduate student in the laboratory rotation

  • Biomedical Technology Commercialization Intern

    Feb 2019 - Jul 2019

  • Postdoctoral Researcher

    Dec 2017 - Jul 2019

  • Graduate Research Assistant

    Aug 2012 - Dec 2017
• 

  City of Hope

  Jul 2019 - Mar 2020

  Postdoctoral Fellow

  Beckman Research Institute - Department of Systems Biology• Elucidated the mechanisms of therapeutic resistance in leukemia• Explored lysosomal biology and autophagy

• 

  Ab Studio

  Mar 2020 - Mar 2022

  Senior Scientist

  Cell Biology and Assay Development Group• Led multiple antibody discovery and development projects to develop therapeutics for difficult-to-treat diseases including different cancer types• Developed and performed cell-based assays to functionally validate therapeutic monoclonal, bispecific, T cell engager, trispecific, and complex antibodies including ADCs• Cell biologically validated mechanisms of action of therapeutic antibodies• Developed a novel technology platform for improved antibody-based therapeutics• Provided scientific insight to prepare company presentations, study reports, manuscripts, marketing materials, and co-ordinated publication efforts of the company• Led scientific communications, collaborations, and partnerships with external biopharmaceutical companies and CROs• Mentored and guided junior scientists Show less

• 

  Prellis Biologics

  Mar 2022 - Apr 2023

  Senior Scientist, Immunology

  Cell Biology Group• Antibody discovery using the Externalized Immune System (EXIS™) platform• Functional validation of therapeutic antibodies• Lymph node organoid (LNO) culture and characterization• Immune cell characterization by multi-color flow cytometry

• 

  Pfizer

  May 2023 - now

  Cellular BiomeasuresQuantitative Biomarkers and Biomeasures GroupPharmacokinetics, Dynamics and Metabolism DepartmentPfizer Research and Development• Leading projects to develop and implement flow cytometry and imaging cytometry assays to quantitatively measure targets and functions of biologics in cell lines, primary cells, and pre-clinical study samples• Primary cell characterization by multi-color flow cytometry• Participation in all phases of cellular biomeasures, including experimental design and execution, data analysis, interpretation, and reporting• Exploring new workflows and technologies, and leading technology implementation to expand the technical capabilities in the team• Functioning as a mentor for junior group members, subject matter expert in immunology and flow cytometry, and a collaborator with other functional groups Show less

  • Principal Scientist

    Dec 2023 - now

  • Principal Scientist

    May 2023 - Nov 2023