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Raúl Carrillo Casado

Raúl Carrillo Casado

Student Intern

Followers of Raúl Carrillo Casado143 followers
location of Raúl Carrillo CasadoUppsala, Uppsala County, Sweden

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  • Timeline

  • About me

    Biotechnologist

  • Education

    • Uppsala University

      2021 - 2023
      Master's Programme in Chemistry Chemical Biology

      Master's Thesis: Fragment-based design of SARS-CoV-2 PLpro inhibitors using molecular modeling techniques

    • Universidad de Granada

      2016 - 2020
      Bachelor's degree Biotechnology

      Bachelor's Thesis: Optimisation of a positive validation assay based on chemical denaturation experimentsAwarded with 9.9/10 (Distinction with Honor)My main goal was to both validate and estimate the binding of a promising antiviral candidate to the Tsg101-UEV human domain. In order to tackle this challenge, I performed urea denaturation experiments followed by intrinsic fluorescence. This type of ligand-protein interactions represent a potential strategy in the fight against… Show more Bachelor's Thesis: Optimisation of a positive validation assay based on chemical denaturation experimentsAwarded with 9.9/10 (Distinction with Honor)My main goal was to both validate and estimate the binding of a promising antiviral candidate to the Tsg101-UEV human domain. In order to tackle this challenge, I performed urea denaturation experiments followed by intrinsic fluorescence. This type of ligand-protein interactions represent a potential strategy in the fight against several viral threats like HIV, Ebola or Marburg virus. Show less

  • Experience

    • Universidad de Granada

      Jul 2019 - Sept 2019
      Student Intern

      Professor Irene Luque's Group, Department of Physical-Chemistry- Optimization of a proteomic test for the study of binding specificity to WW domains

    • Universidad de Granada

      Nov 2020 - Aug 2021
      Research Assistant

      Professor Irene Luque's Group, Department of Physical-Chemistry- Expression and purification of protein domains involved in ESCRT machinery: IMAC, SEC, FPLC, SDS-PAGE.- Optimization of MicroScale Thermophoresis as an orthogonal technique in the validation of hits from high throughput screening campaigns.- Maintenance and restocking of standard solutions. Purchase of lab material.

    • Uppsala University

      Jan 2022 - Mar 2022
      Research Project

      Danielson Lab, Department of Chemistry- Study of ternary complexes formed by PROTACs using a SwitchSENSE Biosensor-based approach.

    • Uppsala University

      Jun 2022 - Jul 2022
      Summer Internship

      Danielson Lab, Department of Chemistry- Production and characterization of prolyl hydroxylase: IMAC, SEC, IEC, FPLC, SDS-PAGE.- Immobilization of prolyl hydroxylase on CNBr-activated Sepharose 4B.- Analysis of modified peptides using LC/MS.

    • Uppsala University

      Nov 2023 - Jan 2024
      Research Assistant

      Collaboration between Carlsson Lab (Department of Cell and Molecular Biology) and Danielson Lab (Department of Chemistry)- Fragment-based design of SARS-CoV-2 PLpro inhibitors using Molecular Docking (DOCK3.7).- Biochemical characterization of viral proteases.- Experimental validation of drug candidates using a fluorescence-based protease inhibition assay.- Molecular Dynamics Simulations using GROMACS software.

    • EnginZyme

      Feb 2024 - Jul 2024
      Research Assistant

      - Planning, execution and analysis of enzymatic assays and target reactions using LC-MS.- Enzyme immobilizations and QC of commercially produced enzyme formulations.- Development of automated lab protocols with liquid handling robots for stability studies of catalysts.- Maintenance and restocking of buffers and standard solutions.

  • Licenses & Certifications

    • Python Data Structures

      University of Michigan
      Feb 2025
      View certificate certificate

    • Using Python to Access Web Data

      University of Michigan
      Feb 2025
      View certificate certificate

    • Programming for Everybody (Getting Started with Python)

      University of Michigan
      Oct 2020
      View certificate certificate

    • Cambridge Advanced English (Grade A)

      University of Cambridge
      Jan 2021