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Jose Antonio Silva Lozada

Jose antonio silva lozada

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location of Jose Antonio Silva LozadaVenezuela
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  • Timeline

  • About me

    PhD in Pharmacology

  • Education

    • Universidad del zulia

      1993 - 2001
      Bachelor's degree biology

      The opioid system is important in the neuronal homeostasis of the sensory and cognitive function. Chronic stress is able to generate changes in the neuronal homeostasis; producing increment in c-Fos expression, reduction in GABA-A receptor activation and overactivation of the NMDA receptor. All those changes produce stress-induced hyperalgesia. Likewise, repeated exposure to swimming stress induces a long-lasting hyperalgesia. Since the opioid neurotransmitter system modulates pain, the… Show more The opioid system is important in the neuronal homeostasis of the sensory and cognitive function. Chronic stress is able to generate changes in the neuronal homeostasis; producing increment in c-Fos expression, reduction in GABA-A receptor activation and overactivation of the NMDA receptor. All those changes produce stress-induced hyperalgesia. Likewise, repeated exposure to swimming stress induces a long-lasting hyperalgesia. Since the opioid neurotransmitter system modulates pain, the selective blocking of opioid receptors with opioid-receptors antagonists’ naloxone and naloxonazine, previous to each session of forced swimming, prevents hyperalgesia. Naltrindole and nor-binaltorphimine were inactive. The efficacy of morphine to produce analgesia in a forced-swimming model was lower than in a sham-swimming model. In conclusion, the forced swimming is able to produce overactivation of the opioidergic system inducing long-lasting hyperalgesia. Show less

    • Universidad central de venezuela

      2004 - 2012
      Doctor of philosophy (ph.d.) pharmacology 1/2

      Activities and Societies: Rugby team The reactive oxygen species (ROS) participate in signalling pathways that are important in maintaining homeostasis of neurons. Angiotensin II (ANG II) influences blood pressure via its ability to stimulate the NAD(P)H oxidase. Consequently, ROS such as superoxide are produced, which are sequentially metabolized by the enzymes superoxide dismutase, catalase and glutathione peroxidase; producing oxygen and water among other molecules. ROS in turn, can activate the MAPK pathway that is associated… Show more The reactive oxygen species (ROS) participate in signalling pathways that are important in maintaining homeostasis of neurons. Angiotensin II (ANG II) influences blood pressure via its ability to stimulate the NAD(P)H oxidase. Consequently, ROS such as superoxide are produced, which are sequentially metabolized by the enzymes superoxide dismutase, catalase and glutathione peroxidase; producing oxygen and water among other molecules. ROS in turn, can activate the MAPK pathway that is associated with growth and cellular differentiation. To establish the intracellular mechanism by which ROS mediate neuronal ANG II actions in cardiovascular regulation, we assessed (in vitro) the role of angiotensin AT1 receptor, protein kinase C and NAD(P)H oxidase in the angiotensin II-induced pathway of antioxidant enzymes and MAPK. The structures assessed were related with cardiovascular response; the hypothalamus, the sub-fornical organ and the adrenal medulla. Show less

  • Experience

    • Universidad del zulia, faculty of medicine, institute of clinical research.

      Feb 1998 - May 2001
      Laboratory assistant

    • Universidad del zulia, faculty of sciences, laboratory of organic synthesis and drug design.

      Nov 2000 - Jul 2001
      Researcher assistant

      Responsible for conducting biological evaluation of new agents with dopaminergic activity, performing stereotactic surgery and behavioral tests in rodents.

    • Universidad del zulia, faculty of medicine, institute of clinical research "americo negrete".

      Jun 2001 - Jul 2002
      Researcher assistant

      Responsible for collecting and processing tissues (spinal cord and brain) for determination of c-Fos by immunohistochemistry, carrying out tests of pain and behavior in rodents and making measurements of GABA and glutamate in spinal cord by capillary electrophoresis.

    • Hospitalary corporation of zulia, ca.

      Nov 2002 - Jul 2004
      Sales executive

    • Fonacit, training program for new talent.

      Sept 2004 - Dec 2008
      Scholarship

    • Universidad central de venezuela

      Jan 2009 - Jul 2010

      Responsible for teaching in the postgraduate of toxicology about biomarkers and toxic metabolites derivative of drug, chemical and radioactive substances, and such as the techniques necessary to measure and detection them. Responsible for teaching about agents with activity in the central nervous system, autonomic system and the local anesthetics, antimicrobial therapy and management of diabetes.

      • Professor of Toxicology

        Feb 2009 - Jul 2010

      • Lecturer of Pharmacology (Professor Instructor)

        Jan 2009 - Jul 2010

    • Universidad central de venezuela, faculty of pharmacy, laboratory of neuropeptide

      Jul 2012 - Jul 2013
      Researcher associate

      Responsible for designing experimental protocols, measurement of antioxidant enzymes and MAPK in different nervous tissues, stereotactic surgery, behavioral tests in rodents and tissue extraction.

  • Licenses & Certifications

    • Gcp for investigator and investigational site staff

      Pharmaschool
      Aug 2016

    • Ielts test cefr level b1

      Ielts official
      Jun 2017
      View certificate certificate

    • Ich good clinical practice e6 (r2)

      The global health network
      Mar 2023

  • Honors & Awards

    • Awarded to Jose Antonio Silva Lozada
      “Antonio José Muskus Award”. For the best paper entitled "AT1 Receptor and NAD(P) H oxidase mediate angiotensin II-Stimulated antioxidant enzymes activated protein kinase and mythogen activity in the rat hyphotalamus." School of Pharmacy. UCV. - 2010
    • Awarded to Jose Antonio Silva Lozada
      Prize for the best poster entitled “Effect of aqueous extract of Ruellia root on tuberosa antioxidant enzymes in diabetic rats” presented at the XXXIII scientific conferences of National Institute of Hygiene "Rafael Rangel" - 2009
    • Awarded to Jose Antonio Silva Lozada
      Prize for the best poster presented at the IV conference of research and teaching in XLV anniversary of graduate school of pharmacology and LX anniversary of the creation of the department of Pharmacology at “Universidad Central de Venezuela” - 2009
    • Awarded to Jose Antonio Silva Lozada
      Prize for the best poster presented at the Venezuelan congress of hypertension VIII - 2009
    • Awarded to Jose Antonio Silva Lozada
      Prize for the best scientific work at the X scientific conferences of medical school "Dr. Haydee Soto Parra " - 2001
    • Awarded to Jose Antonio Silva Lozada
      Prize for the best thesis of biology degree "Br. Gomez Benildo Pocaterra " - 2001
    • Awarded to Jose Antonio Silva Lozada
      Prize for the best undergraduate thesis at the University of Zulia, “Dr. Humberto Fernandez Moran " - 2001