Experience

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  University of turin

  Jan 2007 - Feb 2013

  Working as a Research Assistant in the Molecular Genetic laboratory, Department of Clinical and Biological Sciences, University of Turin, Turin Italy. Supervisor: Prof. Claudia Giachino. PhD program in Biomedical sciences and Oncology, specialization in Genetic. Thesis title: “Self-renewal signaling pathways in Induced Pluripotent Stem Cells (iPSCs) and Human iPSCs from Human Mesenchymal Stem Cells. (Thesis available on request). Ph.D. conferment: 14th of April 2011; Supervisor: Prof. Claudia Giachino

  • Research Assistant

    May 2011 - Feb 2013

  • PhD Student

    Jan 2007 - Apr 2011
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  University of bath

  Jan 2009 - Aug 2010

  Marie curie early stage training fellow

  Working at the Regenerative Medicine Centre, University of Bath (UK), Department of Pharmacy and Pharmacology, under the direct supervision of Prof. Melanie Welham, as a Marie Curie Early Stage Training Fellow for the first year, and as a visiting student for the following six months. During this period I have been directly involved in three different projects: 1) Creation of induced Pluripotent Stem Cells (iPS) from Human Mesenchymal Stem Cells using an inducible transposon-based system. 2) Study of self-renewal signaling pathways regulation in murine iPS lines. 3) Investigation of the role of gH2AX basal phosphorylation in Pluripotent Stem Cells. Show less

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  Mcmaster university

  Jan 2018 - Apr 2022

  Thanks to the unique multi-disciplinal approach of Bhatia’s laboratory, I have developed deep knowledge in many expects of epigenetic regulation of human pluripotent cells biology (including Embryonic), human primary Cancers models (including Leukemia), and high-throughput screening of small molecules aiming to develop innovative differentiation therapies for cancer and regenerative medicine. As a result of the strong translational aim of our projects, I have been constantly exposed to different aspects of scientific research, including collaboration with Medical Doctors and Chemists aiming at clinical applications. Some of the achievements of my postdoctoral period include: -developed and led (1st author) the study: Targetable programs of human cancers are ontogenically rooted within cell fate trajectories of pluripotency (currently under review): this work includes the development of a novel high-throughput screening able to identify molecules active on ontogenically linked cancers. Early proposals of this screening system development allowed the award of Stem Cell Network translation impact grant (2017), which warranted funding application of this system for my studies; -developed and led (1st author, Cell Reports 2021) the study: Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decision: the development of this work made me proficient in many genetic and molecular techniques (including Crispr/Cas9, ChIP, etc. ) and pluripotent cells differentiation (neural/hematopoietic stem cells and full maturation in neurons/blood); -since 2018, I have been responsible for the coordination of all the projects (6-10) involving target identification of lead small molecules, directly supervising a team of 10+ trainees and technicians. Show less

  • Academic Research Associate - Bhatia program in Experimental Therapeutics and Human Leukemias

    Feb 2020 - Apr 2022

  • Post Doctoral Researcher - Stem Cell and Cancer Research Institute

    May 2013 - Jan 2020

  • Lecturer

    Jan 2018 - Feb 2018
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  Artisan bio

  May 2022 - Apr 2023

  • Process & Analytical Development for CRISPR-based gene editing of iPSCs; demonstrated best in class efficiencies of CAR KI > 50% KO > 90% and developed flow cytometry-based assays to quantify intermediate quality attributes. • Implemented and further optimized Quality by Design (QbD) principles including but not limited to risk assessment-based development and continuous improvement mentality.• Completed multiple partners/clients related projects from initial meetings as a subject-matter expert to execution, reports, and technology transfer. Show less

  • Senior Scientist, iPSC editing

    Apr 2023 - Apr 2023

  • Scientist II, Process Development Analytics

    May 2022 - Mar 2023
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  Bluerock therapeutics

  May 2023 - now

  Senior scientist analytical development

  • Leading the Analytical Development Flow Cytometry team, I am focusing on developing phase-appropriate Cell quality, identity, and potency assays strictly collaborating with both Discovery and Quality Control departments across the Company's multiple sites. Moreover, I proactively identify gaps and develop methods to facilitate multiple Program and Platform advances.