Hilda Solanoy

Experience

• 

  Gladstone Institutes

  Mar 1998 - Apr 2010

  • Routinely performed tissue biopsies, assist postdoctoral fellows and scientists with transcardial perfusions and performed complex surgical procedures• Managed and maintained complex mouse colonies totaling 1500 cages with over 40 different mouse lines• Provided training in the areas of animal handling, surgical procedures and performance feedback to Research Associates and Lab Aides• Distributed mouse lines worldwide while acting as liaison between lab and external organizations in the development of a research collaboration• Maintained animal facility and related equipment• Implemented new breeding procedures for transgenic mice and coordinated IACUC protocol submissions/modifications• Ensured that all lab members have completed and are compliant with animal and safety requirements Show less

  • Senior Research Associate III

    Sept 2008 - Apr 2010

  • Research Associate II

    Sept 2004 - Sept 2008

  • Reseach Associate I

    Sept 2002 - Sept 2005

  • Senior Lab Aide

    Mar 1998 - Sept 2002
• 

  Genentech

  Apr 2010 - Jun 2015

  Scientific Researcher

  • Study coordination, preparation and execution of preclinical in vivo studies encompassing pharmacokinetics, pharmacodynamics, efficacy, toxicology, safety, and model development in various neurodegeneration models• Conduct crucial experiments for assessment and decision making of pipeline projects in pre-ESR, ESR, LSR and ED• Responsible for multiple tissue collection and sample prep, blood collection (submandibular, retro orbital, cardiac) and complex necropsies• Perform compound administration (IV, PO, IP, and SC), to test therapeutic agents using various in vivo mouse models• Perform surgeries such as optic nerve crush, stereotaxic injections, and cranial windows• Biological techniques including Western blotting and immunohistochemistry• Contributed to Investigational New Drug (IND) Application by providing study reports • Consistent interaction with colleagues across teams outside of department to better support research goals• Extensive knowledge and experience of vivarium/facility operations• Play key role in training and guidance of contract employees Show less

• 

  Denali Therapeutics

  Nov 2015 - Nov 2023

  • Overseeing all internal in vivo operations and overall leadership of the vivarium• Developing and implementing solutions, practices, tools, and processes to improve the in vivo resources program to increase efficiency, animal welfare, regulatory compliance, and in vivo research quality• Collaborating with scientists across functions to ensure best practices are used for animal research• Manage, mentor, and train a team of Research and Associate Scientists, Senior Manager and Senior Animal Care Technicians• Ensuring compliance with all federal, state, and institutional regulations, policies and guidelines, and advising the Institutional Officer and executive leadership on all matters related to research involving laboratory animals at Denali• Participating in IACUC committee, Space Planning and EH&S committees• Overseeing training of scientists on the appropriate use of animals in research and validation of new procedures• Providing oversight to researchers on the development and successful implementation of IACUC protocols• Preparing operational summaries to include resource management, forecasting, and capital equipment needs Show less • Manage all core operational activities of the vivarium• Hire, train and develop a diverse workforce to include recruitment and professional development of staff• Strategically align with organizational objectives and priorities to achieve performance management• Responsible for financial management of the vivarium budget and budget forecasts• Orient and train animal care staff, scientists, facilities personnel, contractors, and others accessing the facility on regulations, procedures, and safety/equipment operation• Manage the training, and documentation of training records, for all vivarium staff in coordination with our IACUCappointed representative• Serve as a resource to animal users by providing technical expertise, troubleshooting, problem solving, and assistance while optimizing in vivo procedures • Update and implement vivarium procedures, guidelines, and policies related to the animal care program• Independently interact with other departments (Facilities, EH&S, Procurement, etc.) to integrate and develop necessary programs and policies• Participate as a member of the IACUC and facilitate communication between the IACUC and users of the vivarium • Responsible for overseeing monitoring and compliance of all studies as per IACUC guidelines and approved protocols Show less • Serve on large and small molecule project teams throughout lead/candidate identification, IND-enabling, and Early Clinical Development phases to enable project decision making• Lead efforts to identify robust and translatable target, pathway, and disease biomarkers in relevant animal models of neurodegeneration• Design and implement acute and chronic animal studies to evaluate biological effects of therapeutic candidates• Collaborate with DMPK group to design and implement PK/PD studies as well as Therapeutic Discovery and Clinical Biomarker groups to identify translatable biomarkers across multiple programs • Design and communicate experimental study designs and analyze, interpret, and present data and experimental conclusions to cross-functional teams• Advance clinical candidates; write, edit, and finalize nonclinical sections of regulatory (IND/CTA) filings Show less

  • Director, In Vivo Sciences

    May 2023 - Nov 2023

  • Associate Director, In Vivo Operations

    Feb 2021 - May 2023

  • Senior Manager

    May 2019 - Feb 2021

  • Scientist, Lab Leader

    Nov 2017 - May 2019

  • Senior Research Scientist

    Nov 2015 - Nov 2017
• 

  Altos Labs

  Dec 2023 - now

  Director, In Vivo Pharmacology Operations

  •Provide strategic leadership and direction for the in vivo pharmacology operations, ensuring alignment with company goals and objectives.• Oversee the planning, execution, and management of in vivo studies, including protocol development, monitoring, biosample management and relevant data analysis.• Recruit a team of technical scientists, providing guidance, mentorship, technical training and fostering a collaborative and high-performing work environment.• Collaborate with cross-functional teams, including research, pharmacology, and toxicology, to support the development and progression of therapeutic programs.• Ensure compliance with regulatory guidelines and ethical standards in the conduct of in vivo studies.• Optimize and implement best practices for in vivo research methodologies, including animal model selection, dosing strategies, sample collection and data collection techniques.• Evaluate and implement new technologies and platforms to enhance the efficiency and quality of in vivo studies.• Manage external collaborations and partnerships with contract research organizations (CROs) for outsourced in vivo studies.• Create and foster strong partnerships with groups at the Institutes of Science• Contributes to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion Show less