Parind Desai

Experience

• 

  KBIPER, Gujarat University

  Jan 2004 - Jan 2008

  B.Pharm

  Under-graduation in Pharmaceutical SciencesB.Pharm Project:“Protection against gentamicin induced nephrotoxicity by alcoholic extract of plant Inula racemosa" (team of 3) (July’07-Nov’07)Alcoholic extract of Inula racemosa was prepared by filtration and evaporation. Nephrotoxic model was developed in male wistar rats by administering gentamicin. Biomarkers and histopathological testing confirmed the protective action of plant extract on nephrotoxicity.

• 

  Indian Institute of Technology, Bombay

  Jul 2009 - Jun 2010

  M.Tech Project:“Gold nanoshells and thermosensitive liposomes for breast cancer therapy” (May’09-Jun’10) • Gold nanoshells, thermosensitive liposomes and gold coated liposomes were fabricated and characterized by TEM, SEM, AFM, DLS, zeta-potential, FTIR, calcein release and UV-Vis spectroscopy study. • In-vitro release studies of docetaxel from liposomes were performed to confirm suitability of these developed formulations for dual (photothermal and chemo) therapy. Teaching Assistant of the module BM601-Biomathematics. Responsible for handling class tutorials, evaluating examination papers, organizing disucssion sessions

  • M.Tech Research Scholar

    Jul 2008 - Jun 2010

  • Teaching Assistant

    Jul 2009 - Dec 2009
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  National University of Singapore

  Aug 2010 - Jul 2015

  PhD Project: “Study of disintegrants and disintegration phenomena”• Examined actions of disintegrants by high speed video imaging and MATLAB image processing.• Characterized energy and heat changes occurred during disintegration process by solution calorimetry. • Innovated a responsive disintegration test apparatus using computational fluid dynamics and studied RDT disintegration phenomena using this fabricated apparatus. • Identified optimized blends of disintegrant polymers by Design of Experiments (DoE) study and implemented Quality by Design (QbD) paradigm to formulate RDTs by direct compression technology.Received "Best Graduate Researcher Award" from Department of Pharmacy, National University of Singapore. Show less

  • Research Associate, GEA-NUS Pharmaceutical Processing Research Laboratory

    Sept 2014 - Jul 2015

  • PhD Research Scholar, GEA-NUS Pharmaceutical Processing Research Laboratory

    Aug 2010 - Aug 2014

  • Teaching Assistant

    Aug 2010 - Aug 2014
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  Merck

  Jul 2013 - Oct 2013

  Research Intern

  Project 1: Investigating root causes of reduced API dissolution of tablet formulationKepner-Tregoe analysis was performed to break down the complexities of the problem. The effects of operation process parameters and raw material attributes were analysed. Scatter plots, contour plots and multivariate data analysis study identified the root cause of the problem. Partial least square regression model was built to predict the API dissolution for future tablet batches. Project 2: Investigating root causes behind nip zone plugging issue during roller compaction processFlow properties of API powders were measured using a powder rheometer. The study identified that the cohesiveness of API powders was one of the root causes of the problem.Received “Award of Excellence” for excellent contributions and assistance to the company in short time period. Show less

• 

  Massachusetts Institute of Technology

  Aug 2015 - May 2017

  Postdoctoral Associate, Novartis-MIT Center for Continuous Manufacturing, Dept of Chemical Engg

  • Established an integrated hot-melt extrusion - injection molding platform for continuous tablet manufacturing.• Studied formulation design space and critical process parameters required for the optimal performance of hot-melt extruded and injection molded tablets.• Analyzed potential coating polymers and process parameters suitable for the solvent-free injection coating technology.• Collaborated with interdisciplinary scientists from MIT & Novartis, updated research findings on a timely basis and provided recommendations to other team members for their research work. Show less

• 

  GSK

  Jun 2017 - now

  Leading a technical team of 8 process engineering & PAT scientists in Process Engineering & Analytics, Drug Product Development dept, to deliver steriles portfolio (7+ long acting injectables, 1 oligonucleotide) with following responsibilities.1) develop robust manufacturing processes and platforms for the pipeline portfolio spanning phase I to phase III and launch2) work closely with formulators, analytical scientists, materials scientists in the CMC drug product development journey and deliver assets to their respective milestones3) develop and deploy PAT tools and strategy for this portfolio4) implement predictive approaches to accelerate product development5) enhance and integrate the fundamental understanding of materials science to manufacturing process and performance.Current process/platform and PAT focus of the team: wet bead milling, lyophilization, solid-liquid & liquid-liquid mixing, filtration, filling, PAT for these processes- Process Engineering & Analytics Lead for a late-stage oligonucleotide asset – selected and implemented a commercial non-platform mixing technology for this challenging asset, deploying online Raman and pH PAT for the asset.- Leading active GSK collaborations with external industrial and academic groups in the areas of process development, formulation and modeling.Note: Fellows program across the company was terminated in Feb 2024. Show less - Steriles and Biopharm Drug Product Modeling Lead (cross-functional matrix team) with an accountability to embed Digital Design (data-driven, hybrid and mechanistic modeling) to accelerate & transform product development (May’22 - Dec’22)- Led a cross functional strategy of materials characterization workflow (MCW) for parenteral LAIs. Conceived and employed API sparing predictive tools to identify API processability and accelerate product development. Infused “predict-first” collaborative culture in daily project executions.- Industrial Advisory Board Member, representing GSK in CIMSEPP (10+ Industry & 2 University research center) (May’22-Jan’24) Show less - Process Engineering & Analytics Lead for 4 oral solid & 2 parenteral LAIs spanning phase I to III. Delivered and implemented drug product processes (roller compaction, blending, continuous & batch direct compression, wet bead milling, solid-liquid mixing) for successful formulation, process development, scale-up and tech transfer.- Developed roller compaction process at GSK. Established, validated and executed predictive mechanistic models and materials analysis. Scaled up the process at CMO site. As a team, we supplied Phase-III products for patients ahead of schedule.- Developed a viable and scalable wet bead milling processes and evaluated formulation attributes for a parenteral suspension in 1-week timeline for GLP manufacturing, reduced process time by >50%, defined phase-I process 6 months early.- Presented accomplished work in technical project reviews, town hall meetings, engagement sessions and CMC/MPD meetings. Coauthored IND, IMPD, NDA submissions and technical reports.- Developed, led & implemented a cross functional strategy – Materials Characterization Workflow (MCW) to all oral solids. MCW enabled rapid & early manufacturability assessment with <50 g API, empowered optimization of API/formulation properties, crystallization processes and use of simpler manufacturing platforms early in lifecycle.- Led the matrix “Flow” work stream, member of “Segregation” and “Implementation” work streams. Developed advanced characterization tools, applied new ways of working in flow, segregation & compaction fields.- Led active GSK collaborations with external industrial and academic groups in materials Science (segregation, flow), process development, formulation and modeling fields. Show less

  • Associate Director

    Nov 2023 - now

  • Team Leader (Steriles Process Engineering), GSK Fellow

    Oct 2022 - Oct 2023

  • Scientific Leader, GSK Fellow

    Nov 2021 - Sept 2022

  • Investigator, GSK Fellow

    Mar 2021 - Oct 2021

  • Investigator, GSK Associate Fellow

    Sept 2019 - Feb 2021

  • Investigator

    Jun 2017 - Aug 2019