Sumanth Mannepalli

Experience

• 

  Anthem Biosciences Pvt. Ltd.

  Sept 2009 - Sept 2011

  Scientist

  Anti-microbial susceptibility assays as per CLSI guidelines. Microbial culture collection, propagation andmaintenance.

• 

  GangaGen Biotechnologies Pvt. Ltd.

  Sept 2011 - Dec 2011

  Senior Research Associate

  Isolation and determination of bacteriolytic activity of bacteriophages against specific pathogenic bacteria.

• 

  Connexios Life Sciences(P) Ltd

  Dec 2011 - Mar 2013

  Scientist

  Determination of cytotoxicity and genotoxicity of new chemical entities (NCE) by in vitro and in vivo experiments as per OECD guidelines.

• 

  Strand Life Sciences

  Apr 2013 - Mar 2015

  Senior Scientist

  o Interpret clinical significance of rare disease gene variants identified through Whole Exome Sequencing (WES), Whole Genome Sequencing (WGS) and targeted NGS or Sanger DNA sequencing platforms, perform variant classification according to the ACMG guidelines and issue clinical diagnostic reports.o Personalized medicine for cancer genomics - Interpret therapeutic and prognostic significance of cancer genomic variants after a thorough review of medical genetics literature and public databases.o Generate high-quality customized clinical reports.o Variant classification and reclassification following ACMG guidelines.o Curation of variants, gene-disease correlations, therapeutic and prognostic information using internal datasets, online resources, and published literatureo Lead a time of three scientists for an in-house gene-disease curation project. Show less

• 

  CENTOGENE

  Apr 2019 - now

  > Genetic data analysis, clinical reporting and variant curation• Clinical analysis of next-generation sequencing (NGS) data, perform variant classification and clinical reporting and curation.> Product Management for the in-house genetic data curation database• Collaborate with different teams and develop product’s goals and objectives.• Write clear product requirements, user stories, and specifications for development teams. Prioritize features based on business value, feasibility, and user feedback.• Create and maintain a product roadmap, which outlines the key features and timelines for product releases.• Participate in sprint planning, backlog grooming, and stand-ups in agile environments.• Work closely with the development teams to ensure timely product delivery and resolve any issues that arise during the development process.• Oversee product user acceptance tests (UAT) and gather feedback from users, stakeholders, and internal teams to refine the product.• Contribution to quality management (QM) related topics such as standard operating procedure (SOP) or events> Project Management for in-house variant classification projects• Define the project scope and objectives. • Develop a detailed project plan, including timelines and resources, define roles and responsibilities.• Manage project risks/issues and keeping stakeholders informed with regular status reports.• Ensuring the project is competed as per the stakeholder's expectations.> Leadership and Team Management• Manage a team of six scientists. Set clear and measurable goals.• Assigning tasks based on team members' skills and strengths, and ensuring the workload is evenly distributed.• Offering the team guidance on tasks completion and overcoming challenges.• Tracking the team’s progress and keeping the team engaged, motivated, and focused on their work. • Ensuring the team has resources they need to perform their regular tasks.• Conducting performance review and feedback sessions. Show less

  • Head - Genetic data curation and Variant classification

    Apr 2022 - now

  • Supervisor - Genetic data curation and Variant classification

    Apr 2021 - Mar 2022

  • Senior Curation Scientist

    Jul 2020 - Mar 2021

  • Curation Scientist

    Apr 2019 - Jun 2020