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Francesca Mattedi

Francesca Mattedi

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location of Francesca MattediLondon Area, United Kingdom

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  • Timeline

  • About me

    Postdoc at UCL - Institute of Neurology

  • Education

    • Liceo Scientifico Andrea Maffei

      2007 - 2012
      Scientific High School Diploma 100/100

      Main subjects:▪ Chemistry▪ Biology▪ Mathematics▪ Physics▪ Latin▪ Italian and English Literature ▪ Philosophy▪ History

    • Università degli Studi di Trento

      2015 - 2017
      Master of Science in Cellular and Molecular Biotechnology 110/110 with honor

      Activities and Societies: ▪ Vice-president of Students’ Council at University of Trento ▪ CIBIO Students’ Representative at University of Trento Master thesis: "Investigating translation in Amyotrophic Lateral Sclerosis: an emerging role for wild-type and mutant FUS in primary spinal neurons"

    • Ludwig-Maximilians Universität München

      2016 - 2016
      ERASMUS Program Master in Biology

      Five months exchange program at Ludwig-Maximilians-Universiät München, from March 2016 until July 2016.

    • King's College London

      2018 - 2022
      Doctor of Philosophy - PhD Neurobiology

      Optogenetic approaches to study mitochondrial dynamics and function: implications for neuronal ageing

    • Università degli Studi di Trento

      2012 - 2015
      Bachelor of Science in Biomolecular Sciences and Technology 110/110 with honor

      Activities and Societies: ▪ Vice-president of Students’ Council at University of Trento ▪ CIBIO Students’ Representative at University of Trento Bachelor thesis: "Translational defects in spinal cords and brains of a mouse model of severe Spinal Muscular Atrophy"

  • Experience

    • Consiglio Nazionale delle Ricerche

      Feb 2015 - Oct 2015

      Institute of Biophysics - Viero LabCharacterization of SMN protein role in axons of motor neurons. Analysis of SMN lack in SMA (Spinal Muscular Atrophy) affected neuronal tissues, focusing on the effects on protein synthesis and mRNA metabolism. Institute of Biophysics - Viero LabAnalysis of SMN protein role in mRNA axonal transport and metabolism, in both native and SMA (Spinal Muscular Atrophy) affected mouse tissues.Main techniques:▪ Polysome purification from tissues▪ Polysome profiling▪ Protein extraction and quantification ▪ RNA extraction▪ Gel electrophoresis▪ Western Blot▪ PCR▪ Ribosome profiling

      • Research internship

        Aug 2015 - Oct 2015

      • Bachelor internship

        Feb 2015 - Jul 2015

    • The University of Edinburgh

      Aug 2015 - Sept 2015
      2 weeks Internship

      Centre for Integrative Physiology - Gillingwater LabMain techniques:- primary culture of motor neurons- immunocytochemistry- synaptosome preparation from mouse brains- quantitative fluorescent western blotting- mouse genotyping- phenotypic analysis of mouse models of SMA- microdissection of tissue (including brain and spinal cord)

    • LMU - Ludwig-Maximilians-Universität München

      May 2016 - Jul 2016
      Internship - Research course in "Cellular and molecular mechanisms of neurodegeneration"

      BioMedizinisches Centrum (BMC) - Dormann LabIsolation and characterization of the composition of FUS-containig and TDP43-containing mRNA granules, in order to understand which proteins and which transcripts are found in these structures.Main techniques:▪ Nuclear - cytosolic fractionation from tissue▪ Immunoprecipitation▪ Western Blot▪ Real Time PCR

    • UCL

      Mar 2017 - Jul 2017
      Master Internship

      UCL, Institute of Neurology - Prof. Giampietro Schiavo and Dr. Pietro Fratta research groupsInvestigating translation in ALS.Main techniques:- Isolation and culture of ventral-horn spinal neurons- Cell culture in microfluidic chambers- Immunofluorescence- Confocal microscopy- Live cell imaging- Immunoprecipitation and western blot

    • Consiglio Nazionale delle Ricerche

      Aug 2017 - Dec 2017
      Master Internship

      Institute of Biophysics - Viero LabInvestigating translation in ALS.Main techniques:- Polysome profiling- Western blot- Protein and RNA extraction from polysomal fractions- qPCR- Subcellular fractionation of ribosomes and polysomes

    • King's College London

      Jan 2018 - Jun 2022

      Investigating mitochondria dynamics and function during ageing in Drosophila Intracellular transport of mitochondria in vivo: implications for neurodegeneration and aging.

      • Research Assistant

        Mar 2022 - Jun 2022

      • PhD student

        Jan 2018 - May 2022

    • UCL

      Jul 2022 - now
      Postdoctoral Research Fellow

      Investigating the molecular mechanisms of TDP-43 loss of function in ALS pathogenesis in human iPSC-derived lower motor neurons.

  • Licenses & Certifications

    • First Certificate in English (FCE)

      University of Cambridge ESOL Examinations
      May 2012

    • IELTS Academic - Overall Band Score: 8.0 - CEFR Level: C1

      British Council
      Sept 2016

  • Honors & Awards

    • Awarded to Francesca Mattedi
      Merit Prize 2015 University of Trento May 2016 The Merit Prize is an award assigned every year to graduated students that reached excellent results during their degree.
    • Awarded to Francesca Mattedi
      Member of Collegio di Merito "Bernardo Clesio" University of Trento Sep 2015 The Collegio di Merito Bernardo Clesio is a project promoted by the University of Trento in cooperation with the Opera Universitaria and sponsored by the Fondazione Cassa di Risparmio di Trento e Rovereto. It intends to offer to the most talented and motivated students the opportunity to access advanced training, within the framework of the University policies, which focus on the students and aim at quality.