Brendan Mackey

Experience

• 

  Bates College

  May 2018 - May 2019

  The terpene class of molecules were evaluated for their potential to reduce inflammation and modulate bacterial growth. Human microbiota were exposed to terpenes and monitored to assess their suitability for future experiments in which genetic engineering would facilitate the creation of microbes that could synthesize terpenes at therapeutic concentrations. These efforts promoted an increased understanding of terpene bioactivity and commensal bacteria behavior that furthered efforts toward a novel treatment for dermatological conditions. Show less Evaluated the mechanism of inositol 1,4,5-trisphosphate receptor-binding protein (IRBIT) in the regulation of intracellular calcium signaling. A CRISPR-Cas9 mediated knock-in was used to alter serine-68 of IRBIT to alanine, thereby inhibiting a phosphorylation event that has been shown to be necessary for activation. Live-cell confocal imaging assays were developed with fluorescent calcium-sensitive dyes to analyze calcium signals in wild-type and knock-in human embryonic kidney cells (HEK293). These efforts developed the methods and cell constructs needed to further understand the misregulation of calcium signaling in diseases like Alzheimer's, Parkinson's and Huntington's. Show less

  • Vice President | Bates College Public Health Initiative

    Sept 2018 - May 2019

  • Emergency Medical Technician | Bates College Emergency Medical Services

    Sept 2017 - May 2019

  • Research Assistant | O’Loughlin Lab

    Sept 2018 - Apr 2019

  • Research Assistant | Kruse Lab

    May 2018 - Jul 2018
• 

  United Ambulance Training Center

  Apr 2019 - May 2019

  Teaching Assistant

  Assisted with full-time instruction of accelerated EMT-B certification coursework. Developed lesson plans in coordination with the lead instructor to educate students on protocols and use of emergency medical equipment in preparation for psychomotor examination at the national level.

• 

  Beth Israel Deaconess Medical Center

  Jun 2019 - Jul 2021

  Evaluated the suitability of study candidates based upon knowledge of disease assessments and 30+ phase I, II, and III multiple myeloma clinical trials. Ensured compliance with IRB/FDA regulations and tracked patient status from enrollment to end of study for 25+ clinical trials. Troubleshooted protocol logistics and reported serious adverse events, violations, and eligibility exceptions to investigators, trial sponsors, and affiliated IRBs. Entered lab orders and managed pharmacokinetic research sample collection and processing. Performed protocol-indicated electrocardiograms and assisted with bone marrow biopsy and aspiration procedures. Show less

  • Clinical Research Coordinator II | Hematologic Malignancies & Cellular Immunotherapies

    Sept 2020 - Jul 2021

  • Clinical Research Coordinator I | Hematologic Malignancies & Cellular Immunotherapies

    Jun 2019 - Sept 2020
• 

  Reading Hospital

  Mar 2022 - Aug 2022

  Research Assistant | Surgery
• 

  Penn Medicine, University of Pennsylvania Health System

  May 2022 - now

  • Resident Physician | Anesthesiology

    Mar 2025 - now

  • Research Assistant | Anesthesiology & Critical Care, Penn Lung Rescue Team

    May 2022 - now
• 

  DrExcel Health - Sling Health National Network

  Sept 2022 - Apr 2023

  Research Assistant | Surgery, Biomechanical Engineering
• 

  Drexel University College of Medicine

  Apr 2023 - now

  • Executive Vice President | Student Government Association

    Apr 2024 - now

  • Student Ambassador | Office of Admissions

    Jan 2023 - now

  • Peer Advisory Program | Student Academic Support Office

    Jan 2023 - now

  • Big/Little Peer Advisory Program | Student Academic Support Office

    Aug 2022 - now

  • President, Class of 2025 | Student Government Association

    Apr 2023 - May 2024