Amit Saraf

Experience

• 

  All India Institute of Medical Sciences

  Jan 1995 - Jan 2000

  `Studied the role of adenosine and melatonin in FeCl3-induced rat model of posttraumatic epilepsy.

  • M.Sc. Pharmacology

    Jan 1998 - Jan 2000

  • B.Sc. (Hons.) Human Biology

    Jan 1995 - Jan 1998
• 

  McMaster University

  Jan 2001 - Jul 2002

  M.Sc. Student- Biomedical Sciences

  Studied the effect of Non-Adenine based Purines in animal model of wound healing (normal and diabetic mice).

• 

  The University of Iowa

  Aug 2002 - Nov 2009

  Studied dephosphorylation of Tyrosine hydroxylase, the rate limiting enzyme in dopamine biosynthesis, by Protein Phosphatase 2A.Identified a specific regulatory subunit of PP2A as a TH phosphatase.Identified specific amino acids as key regulatory residues involved in the interaction of TH and PP2A/B'beta subunit.

  • Postdoctoral Research Fellow

    Jan 2009 - Nov 2009

  • Graduate Research Fellow

    Aug 2002 - Dec 2008
• 

  University of Michigan

  Mar 2010 - Apr 2011

  Postdoctoral Research Fellow

  Studied interaction of LRRK2 ( protein involved in Parkinson's disease) with microtubules in cells and mouse brain

• 

  University of Washington

  May 2011 - Apr 2014

  Senior Research Fellow

  Studied the role of circadian oscillations on learning and memory in mice.

• 

  Pad. Dr. D.Y.Patil University

  Aug 2014 - Dec 2014

  Assistant Professor

  Teaching Undergraduate and Post-Graduate Students.

• 

  Gennova Biopharmaceuticals

  Jan 2015 - now

  • Played a key role in regulatory approval of tenecteplase (TNK-tPA) for acute ischemic stroke, only the 2nd drug approved worldwide for ischemic stroke.• Directly involved in the Phase-III Clinical trial of TNK-tPA for ischemic stroke (Trial Monitoring, Site Initiation, Site Close Out, Report Preparation, Package Insert Information, Data Presentation, etc.)• Work with cross functional teams for successful marketing of TNK‑tPA for acute ischemic stroke.• Design preclinical efficacy and toxicity studies for different biopharmaceutical products (therapeutic area: oncology, blood disorder, etc.)• Audit and select CROs for toxicity studies. • Author clinical trials related documents (manuscript, summary report etc.).• Interact and Engage with Key Opinion Leaders. • Co-Supervised M.Tech. (Biotechnology) Student (Pune University), for a project involving PEGylated product for blood disorder. Show less

  • Deputy General Manager

    Apr 2022 - now

  • Assistant General Manager

    Jul 2020 - Mar 2022

  • Manager (Clinical and Preclinical)

    Jul 2016 - Jun 2020

  • Assistant Manager (Preclinical and Clinical)

    Jan 2015 - Jun 2016