MOORTHY T

Experience

• 

  Biocon Biologics

  Jan 2016 - Mar 2023

  • Planning & Leading the shift activity with team member.• Working as shift lead with 15 members in Bioreactor operations.• Function as a technical lead to execute, analysis and report on biopharmaceutical process research and development projects in the large molecule projects.• Provide technical direction and technical oversight to research projects, under the guidance and support of the Senior Scientist/Team Lead.• Reviewing the batch BMR in eLN-LIMS.• Reviewing the batch protocols for process changes.• Implemented the cost reduction in unit operations.• Process qualification for instruments and equipment.• Executing the procurement for batch consumables.• Preparing SOP, IOP & EOP.• Responsible for planning and execution of project.• Act as a senior presence in the lab and a mentor to junior team members.• Support critical lab and equipment maintenance.• Support the development and introduction of new techniques, methods and processes to improve business effectiveness, as required.• Prepare/Support the preparation of technical presentations and report writing.• Review of IQ, OQ and PQ Qualification documents from User side Show less • Working as a team player with 15 members in Bioreactor operations.• Experienced in aseptic methods of media and feed preparation.• Planning, Micro scheduling and Distribution of the shift activities.• Planning and proposing the raw materials and consumables.• Identified the root cause analysis of leakage issues in Bioreactor connection assembly.• Responsible for online filling and reviewing of quality documents of Batch checklists, annexure and logbooks.• Handled stirred tank, Stainless steel and Single use bioreactors (10L,50L)• Handled wave bioreactors (20L).• Operation of ATF2,ATF4 and ATF6.• Training the team on HPLC operations of amino acid and IgG analysis.• Preparation of Quality documents such as Batch checklist, Annexure, etc. Show less • Supporting the team for Media and Feeds preparation, filtration.• Vial thaw and inoculum maintenance.• Material supplement for batch start to end.• Inoculum suspension for scaling up.• Analyzing the media, feed and compilation the results.• Analysis of the amino acid residual levels by reverse phase chromatography.• Analysis of protein-A by Affinity Chromatography.• Coordinated with maintenance team for periodic maintenance activities and Equipment / Instruments troubleshooting.• Assisted in Preparation of Quality documents such as Batch checklist, Annexure, etc Show less

  • Senior Executive

    Apr 2022 - Mar 2023

  • Executive

    Apr 2019 - Mar 2022

  • Junior Executive

    Jun 2016 - Mar 2019

  • Research Intern

    Jan 2016 - May 2016
• 

  Reliance Life Sciences Pvt. Ltd.

  Apr 2023 - now

  Deputy Manager

  • Focused on enhancing recombinant viral vectors through process development by transient transfection.• Designing experiments, refine, optimise, trouble shoot bioreactor studies at vector development process.• Optimization's of clarification studies. Good understanding of lentiviral vectors (or other gene therapy vectors), and associated product quality attributes.• Lentivirus production HEK293T cells.• Supporting to plasmid DNA batches(Microbial).• Cell banking and maintenance in liquid nitrogen.• Handling wave bag (1L,5L,10L & 20L).• Handling Bioreactors (5L ,10L).• Provide R&D laboratory support across the Bioprocess Development department through collaboration with other scientists and engineers internally and externally.• Working within a research team to plan, organize and execute R&D biopharmaceutical research projects. Support the tech transfer, development and/ or optimization of cell culture.• Processes (adherent/microbial/mammalian) and upstream unit operations (scale-up train/production bioreactors/perfusion/primary clarification).• Write and follow an experimental protocol.• Demonstrated experience in cell culture techniques for adherent cultures and suspension culture systems. Show less