Mumine Senturk, Ph.D.

Experience

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  Burgen Prenatal Diagnosis of Genetic Diseases Center

  Aug 2007 - Sept 2007

  Summer Intern

  - Acquired basic laboratory skills through observation and hands-on practice.- Gained practical insights into genetic disorders and diagnostic procedures while working with a professional team.

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  Genetics and Bioengineering Department @ Yeditepe University

  Jan 2008 - Jun 2008

  Intern

  I worked in Dr. Fikrettin Sahin's lab.• Gained hands-on experience on stem cell research.• Participated in a research project focusing on differentiation of stem cells and neuron-like cells derived from humans.

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  Boğaziçi University

  May 2008 - Aug 2008

  Undergraduate Student Researcher

  Department of Chemistry• Successfully isolated drug enantiomers using chiral HPLC.• Performed asymmetric syntheses with axially chiral heterocyclic compounds.

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  Harvard Medical School

  Jun 2009 - Sept 2009

  Undergraduate Intern

  I worked in Dr. David A. Williams' lab as a summer intern. • Performed in vitro experiments to explore the role of Rac GTPases (and RhoH) in leukemia, resulting in a peer-reviewed article.• Assisted in literature reviews, data analysis, and interpretation of results.

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  Boğaziçi University

  Oct 2009 - Jun 2010

  Undergraduate Research Assistant

  Department of Molecular Biology and Genetics• Participated in identification of disease genes and population genetics research.• Explored genes associated with the age of onset in Huntington’s Disease.

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  Baylor College of Medicine

  Aug 2010 - Jan 2018

  Ph.D. student

  Dr. Hugo Bellen's laboratory (https://flypush.research.bcm.edu/lab/)✔️Led and supported research projects from inception to publication, conducting experiments, data collection, and analysis, resulting in over 5 peer-reviewed publications in prestigious journals.Projects included:o Investigating the role of mTOR and lysosomal function in neuronal maintenance and identification of a novel role for an ALS-causing gene.o In vivo acidic nanoparticle delivery to restore impaired lysosomal activity in ALS mutants. o Modeling neurodegenerative proteinopathies such as Alzheimer’s and Parkinson’s diseases in vivo to assess functional genetic interactions and molecular mechanisms.o Development of preclinical pharmacological approaches targeting ER stress sensors in ALS models.o Exploration of nucleocytoplasmic transport defects caused by C9orf72 repeat expansions.✔️ Collaborated with the PI to contribute to successful grant proposal development, resulting in secured funding for critical research projects.✔️ Effectively communicated research findings through presentations at conferences, weekly lab meetings, and journal clubs, while providing mentorship and supervision to over 5 students.✔️ Demonstrated ability to multitask, problem solving, and proactive troubleshooting while delivering high quality work. Show less

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  Jan and Dan Duncan Neurological Research Institute

  Jul 2018 - Mar 2019

  Postdoctoral Fellow

  Dr. Hugo Bellen's laboratory (https://flypush.research.bcm.edu/lab/)✔️Maintained clear communication with interdisciplinary teams in the Undiagnosed Diseases Network (UDN), addressing complex medical challenges and offering trusted input into neurology.✔️Conducted in vivo functional studies on disease-associated variants of rare and undiagnosed human cases and identified candidate mutations in a novel gene for a progressive neurological disorder, leading to a peer-reviewed publication.

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  Howard Hughes Medical Institute

  Mar 2019 - May 2024

  Postdoctoral Associate

  Dr. Meng Wang's laboratory (http://mengwanglab.org/)✔️Drove complex, time-sensitive research on mitochondria-lysosome communication during aging and nutrient-deprivation using proximity labeling, receiving superior performance reviews.✔️Collaborated with colleagues to explore the mitochondrial metabolism in reproductive aging and bacteria-organelle communication, resulting in the publication of a peer-reviewed article and a review paper (currently in revision).

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  Rethix

  Nov 2023 - May 2024

  Intern

  Rethix is a molecular diagnostics and clinical research startup company.✔️ Provides clinical and scientific input for the development of Clinical Research Training modules.✔️ Provides scientific support to CRO activities, including clinical trial management, and data analysis. ✔️ Actively contributes to the development of SOPs and regulated protocols.✔️ Assists in development and implementation of CLIA regulations and standards, ensuring compliance and adherence to quality practices in clinical laboratory operations.✔️ Manages market research initiatives, overseeing the planning, execution, and analysis phases.✔️ Stays up-to-date on the latest scientific and medical advancements in drug development and clinical trial processes. Show less

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  Baylor Genetics

  Jun 2024 - now

  Clinical Genomic Scientist