Maureen Malloy

Experience

• 

  Wesleyan University

  Jun 2011 - Aug 2011

  Howard Hughes Research Fellow

  I worked in the Chernoff lab researching the temporal and spatial variations in macroinvertebrates along the Connecticut and Coginchaug Rivers as a bioindicator of ecosystem health.

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  SIT Study Abroad

  Apr 2012 - May 2012

  The Health of the Outer Reef

  I examined the health of the outer reef off the coast of Ushango, Tanzania by looking at environmental factors as well as bio-indicator species such as sea urchins and algal cover. I used environmental factors such as turbidity and observed fishing habits to infer possible causes of reef damage.

• 

  Wesleyan University

  Jan 2013 - May 2013

  I worked in the Singer laboratory maintaining the caterpillar colony and assisting with data entry and management for parasitic research. I examined changes in rates of herbivory across successional stages of forest after a landslide disturbance in El Yunque National Park, Puerto Rico.

  • Undergraduate Lab Assistant

    Sept 2012 - May 2013

  • Senior Seminar Research Project

    Jan 2013 - Apr 2013
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  West Virginia Department of Environmental Protection

  May 2013 - Feb 2014

  Americorps Member

  • Measured and maintained detailed records of Acid Mine Drainage biomonitoring data for regulatory compliance.

• 

  ICF International

  Mar 2014 - Sept 2017

  Analyst

  • Ran benchmark dose-response models and developed exposure response array tables for a variety of environmental toxicants and health outcomes.• Aided in the development of a toxicological reference database and conducted systematic literature reviews for scientific reviews and risk assessments for the U.S. EPA.

• 

  University of Michigan

  Sept 2017 - May 2019

  Master Thesis Student

  Dana Dolinoy Laboratory, Department of Environmental Health Sciences:• Identified stable alterations in 5-methylcytosine (5mC) and 5hmC at imprinted loci in the adult mouse brain after perinatal bisphenol-A (BPA) exposure. • Designed and optimized pyrosequencing assays using bisulfite/oxidative bisulfite conversion to measure 5mC/5hmC and to validate epigenetic biomarkers of in utero BPA exposure in the adult mouse brain.

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  US Environmental Protection Agency (EPA)

  Jul 2019 - Sept 2019

  ORISE Fellow

  Brian Chorley Laboratory, U.S. EPA Office of Research and Development• Characterized genome-wide methylation profiles in frozen and archived formalin fixed paraffin embedded (FFPE) adult male rat liver samples after phenobarbital exposure using reduced representative bisulfite sequencing (RRBS) on the Illumina NextSeq500 platform.• Developed a bioinformatics pipeline using Python and R programming to validate epigenomic signatures generated from archived FFPE samples by comparing them with signatures generated using frozen tissue. Show less

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  Johns Hopkins Bloomberg School of Public Health

  Sept 2020 - Aug 2024

  Joseph Bressler and Hernando Lopez Bertoni Laboratory, Department of Environmental Health & Engineering Toxicology, Physiology and Molecular Mechanisms Program • Implemented research identifying epigenetic regulation of the DNA Damage Response and chromatin architecture as targetable mechanisms for enhancing chemo- and radiosensitivity in glioblastoma stem-like neurosphere cell lines.• Designed and executed luminescence and fluorescence plate-based cytotoxicity and immunocytochemistry assays to establish enhanced efficacy of adjunctive ascorbic acid therapy with chemo- and radiotherapeutics and establish dose- and time-response curves.• Developed multiparametric cell-based assays (cell proliferation, viability, apoptosis, migration, mitotoxicity, DNA damage, and protein interaction assays) using immunocytochemistry and fluorescence imaging techniques to assess drug efficacy and elucidate mechanisms of action in patient-derived cellular models. • Established knockdown cell models using liposome-mediated lentiviral transduction techniques, collaborated with the Newby Lab to develop CRISPR/Cas9 knock-out cell models, and optimized high throughput genetic, fluorescence microscopy, and flow cytometry-based screening protocols to identify successfully edited clones.• Analyzed existing literature and publicly available glioma patient RNA-seq and bisulfite-seq datasets (CGGA, TCGA) to generate hypotheses for potential prognostic biomarkers, therapeutic targets, and disease-relevant cellular readouts for glioblastoma treatment resistance and tumor recurrence. Show less

  • PHD Candidate

    Sept 2019 - Aug 2024

  • Graduate Teaching Assistant

    Sept 2020 - Dec 2022
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  The Johns Hopkins University School of Medicine

  Sept 2024 - now

  Postdoctoral Fellowship