Mehdi Dehghani

Experience

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  Jahrom Azad University

  Aug 2007 - Aug 2008

  Visiting Professor
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  The University of Texas Health Science Center at Houston

  Jan 2009 - Apr 2012

  Post Doctoral fellowship
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  Companion Dx Reference Lab, LLC

  Apr 2012 - Nov 2015

  • Research and Development Director

    Feb 2013 - Nov 2015

  • Senior Scientist, Molecular Biology Specialist

    Apr 2012 - Feb 2013
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  The University of Texas Health Science Center at Houston (UTHealth)

  Aug 2014 - Aug 2019

  Department of Internal Medicine-Oncology DivisionDirector of Oncology Division’s Cancer Genomics Laboratory

  • Assistant Professor

    Mar 2017 - Aug 2019

  • Adjunct Assistant Professor

    Aug 2014 - Mar 2017
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  CompanionDx Reference Lab, LLC

  Apr 2015 - Nov 2016

  • Led development and clinical validation of molecular tests under CLIA, NYSDOH regulations and CAP standards, including next-generation sequencing and pharmacogenomics biomarkers (PGX Panel design, workflow establishment, phenotyping and interpretation).• Provided technical, scientific and regulatory direction for clinical laboratory operations. Ensured effective laboratory workflow solutions. Developed strategic plans for future growth of molecular diagnostics services. Assessed and rolled out new molecular tests. Assisted laboratory medical director for facets of clinical laboratory performance, quality, safety, service, budget, policy and procedures, and quality improvement activities.• Assisted the medical director with signing out pharmacogenomics and NGS reports.• Led internally designed and collaborative research projects, including but not limited to:- Identification of rare and hybrid null alleles of CYP2D6 gene- Development and validation of a liquid biopsy test for early detection of colorectal cancer (detection of hypermethylated promoter of SEPT9 gene in plasma)- Design and Development of RCC specific DNA and RNA NGS panels- Led workflow establishment, validations and implementations of a comprehensive NGS assay (Oncomine Comprehensive assay v1)- Collaboration with UTHealth- Oncology division on UT Health Solid tumor molecular registry Show less • Led development and clinical validation of molecular tests under CLIA, NYSDOH regulations and CAP standards, including next-generation sequencing (NGS) and pharmacogenomics biomarkers (PGX Panel design, workflow establishment, phenotyping and interpretation).• Led validation and implementation of an in-house developed high-throughput DNA extraction procedure (DNA extraction from buccal swab samples)• Established a comprehensive workflow for high-throughput pharmacogenetic tesing.• Led validations and implementations of solid tumor NGS panels (Oncomine focus assay).• Led development and validation of pharmacogenetic panels for oncology and non-oncology indications• Provided technical and scientific direction for clinical laboratory operations. Ensured effective and cost cautious laboratory workflow solutions. Developed strategic plans for future growth of molecular diagnostics services. Assessed and rolled out new molecular tests. Collaborated with the Sales and Management team to augment client needs. Served as a consultative resource to clients. Assisted the laboratory medical director for facets of clinical laboratory performance, quality, safety, service, budget, policy and procedures, and quality improvement activities. Show less

  • Vice President of Research and Development/Clinical Laboratory, Assistant Director

    Nov 2015 - Nov 2016

  • Clinical Laboratory, Assistant Director/ Research and Development Director

    Apr 2015 - Nov 2016
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  Applied Diagnostics Inc

  Jun 2016 - Mar 2017

  Molecular Diagnostics consultant

  Provided technical and regulatory directions for molecular diagnostic testing, such as T-cell and B-Cell clonality testing, JAK2, EGFR, KRAS, NRAS, BCR-ABL1 molecular testings.

• 

  Principle Genetics

  Nov 2016 - Mar 2018

  Participated in the establishment of this start-up lab, led the development and clinical validation of molecular tests under CLIA and CAP standards and lead the lab to pass CLIA inspection successfully.• Lead the development and validation of genotyping for genes such as DPYD, UGT1A1, TYMS, SLCO1B1, ABCB1, CYP2D6, CYP3A4, CYP3A5.• Ensured effective laboratory workflow solutions. Collaborated with the Sales and Management team to augment client needs. Served as a consultative resource to clients. Supervised day-to-day lab operations, evaluated lab polices, budget and QC/QA efforts and assisted medical director with signing-out the reports. Show less

  • Clinical Laboratory Director-remote

    Mar 2017 - Mar 2018

  • Clinical Laboratory Director/CSO

    Nov 2016 - Mar 2017
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  Consultative Genomix

  Jan 2019 - Feb 2021

  • Chief Scientific Officer/ Lab Director

    Sept 2019 - Feb 2021

  • Chief Scientific Officer/ Lab Director

    Jan 2019 - Aug 2019
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  BioExcel Diagnostics

  Feb 2021 - now

  Lab Director/CSO/Founder

  • CSO/Lab Director/Founder

    May 2023 - now

  • President/Lab Director

    Feb 2021 - May 2024