Ozgun Le Roux

Experience

• 

  Sabanci University

  Jun 2005 - Aug 2005

  Summer Intern, Sezerman Lab
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  University of North Carolina at Chapel Hill

  Jul 2006 - Sept 2006

  Summmer Intern, Carter Lab

  Designed conserved reverse complementary domains of Tryptophanyl- and Histidyl-tRNA synthetase Urzymes using Rosetta design to demonstrate evidence for Rodin-Ohno hypothesis of reverse-complementary gene coding for Class I and Class II aminoacyl-tRNA synthetases (AARSs).

• 

  University of North Carolina at Chapel Hill

  Aug 2007 - Aug 2016

  Discovered and characterized PHF8 as a major regulator of LPS-induced acute macrophage response (Erdogan, et al. 2016). Designed ancestral Leucyl- and Histidyl-Aminoacyl-tRNA synthetase (AARS) Urzymes using Rosetta protein design and reverse-engineering to understand the evolutionary relationship between conserved domains of AARSs and their enzymatic activities.

  • Graduate Research Assistant, Chen Lab

    Jan 2011 - Aug 2016

  • Graduate Research Assistant, Carter Lab

    Aug 2007 - Dec 2010
• 

  Duke University

  Apr 2017 - Jul 2024

  I leveraged the novel KrasLSL GEMMs with different mutations (G12D vs Q61R) to decipher mechanisms of changes in cell fate in the tumor-initiating cell at the time of tumor initiation exploring *tissue-specific cellular responses and signaling events using scRNAseq*tissue- or mutation-specific synthetic vulnerabilities using genome-wide CRISPR screens Mechanistic exploration of tumor initiation in vivo using genetically engineered mouse models and bulk transcriptomics to identify tissue-specific signaling responses defining oncogenic potential of different RAS mutations (G12D vs Q61R) in different tissues

  • Research Associate Sr.

    Jul 2022 - Jul 2024

  • Postdoctoral Associate

    Apr 2017 - Jul 2022
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  Genentech

  Aug 2024 - now

  Scientist 3, Discovery Oncology