Dilawar Upadhyay, Ph.D.

Experience

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  Sun Pharma Advanced Research Company Ltd.

  Jul 2017 - Nov 2023

  Job Responsibilities: • Development of xenografts and orthotopic mouse models for cancer research• Chronic drug resistance tumor model development and in vivo passage of tumors• Brain metastasis mouse model development for cancer • In vivo bioluminescence imaging in mouse model• Assessment of molecular biomarkers in biological matrices using qPCR, western blot, ELISA, IHC and flow cytometry• Managing and handling multiple in vivo studies to evaluate PK-PD correlation and target engagement• Efficiently work with other teams within the organization and external platforms in response to new business opportunities • Quality documentation and interpretation of experimental results• Data compilation and analysis using MS excel and GraphPad Prism• Presentation of data within a multidisciplinary team environment• Preparation of investigator's brochure (IB) and study reports for IND submission• Perform safety pharmacology studies to support regulatory submissions• Supporting the existing activities as well as establishing novel in vivo models, know-how and capabilities within the team• Identification the CROs and communication to outsource some studies, review of the data and report receivedNotable contribution:• Investigational New Drug (IND) package development (in vivo pharmacokinetics, efficacy, and IND reports preparation) for two anticancer molecules (for CML and ER+ breast cancer), approved for clinical trial in USA Show less

  • Manager - I

    Apr 2021 - Nov 2023

  • Manager II

    Jul 2017 - Apr 2021
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  Aurigene Pharmaceutical Services Limited

  Nov 2023 - now

  Specialist - Pharmacology