Yuko Ono

The 66th Annual Meeting of the Japanese Society of Anesthesiologists, The pitch contest Grant Number A18－3 - Jun 2018 Drug Exploration for Sepsis-Induced Skeletal Muscle AtrophyRole: chief investigatorCollaborators: Kenju Shimomura, Yuko MaejimaTotal cost: \ 900,000Annual direct cost: \ 900,000

JSPS KAKENHI Grant Number 18K16544 Japan society for the promotion of science Apr 2018 Nuclear Factor-kappa B Signaling Inhibition for Sepsis-induced Skeletal Muscle AtrophyJSPS KAKENHI Grant Number 18K16544Role: chief investigatorAnnual direct cost:\ 600,000Total direct cost:\ 2,400,000Total indirect cost:\ 720,000Total cost: :\ 3,120,000The main purposes of this project are to find novel pharmacological intervention to prevent sepsis induced skeletal muscle atrophy. To achieve this goal, we have established in vitro and in vivo models of sepsis… Show more Nuclear Factor-kappa B Signaling Inhibition for Sepsis-induced Skeletal Muscle AtrophyJSPS KAKENHI Grant Number 18K16544Role: chief investigatorAnnual direct cost:\ 600,000Total direct cost:\ 2,400,000Total indirect cost:\ 720,000Total cost: :\ 3,120,000The main purposes of this project are to find novel pharmacological intervention to prevent sepsis induced skeletal muscle atrophy. To achieve this goal, we have established in vitro and in vivo models of sepsis induced skeletal muscle atrophy. Using these models, we seek to determine whether pharmacological inhibition of TLR4/NF-κB signal (1) prevents skeletal muscle degradation; (2) histologically ameliorates skeletal muscle atrophy; and (3) functionally improve skeletal muscle contraction. https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16544/ Show less

JSPS KAKENHI Grant Number 15K20349 Japan society for the promotion of science Mar 2015 Identification of the mechanism of sepsis induced muscle wasting and its potential pharmacological treatmentJSPS KAKENHI Grant Number 15K20349Project Number MO15K20349 Role: chief investigatorAnnual direct cost:\1,100,000Total direct cost:\3,100,000Total indirect cost:\930,000Total cost: :\ 4,030,000We found lipopolysaccharide inhibit muscle differentiation on mouse myoblast (C2C12).The main objects of this project are to determine this molecular mechanism in… Show more Identification of the mechanism of sepsis induced muscle wasting and its potential pharmacological treatmentJSPS KAKENHI Grant Number 15K20349Project Number MO15K20349 Role: chief investigatorAnnual direct cost:\1,100,000Total direct cost:\3,100,000Total indirect cost:\930,000Total cost: :\ 4,030,000We found lipopolysaccharide inhibit muscle differentiation on mouse myoblast (C2C12).The main objects of this project are to determine this molecular mechanism in C2C12 differentiation, and find the useful drug.https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K20349/ Show less

Award for best presentation - Jul 2014 Award for best presentationthe 23rd Annual Meeting of the Japanese Society of Intensive Care Medicine – Tohoku Branch, which was held July 28, 2014, in Yamagata, JapanMassive subcutaneous emphysema, bilateral pneumothorax, pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and pneumoscrotum after multiple direct laryngoscopies: an autopsy case reportYuko Ono et al.