Experience

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  Telethon institute of genetics and medicine

  Feb 2007 - Jan 2010

  Phd student

  I developed a novel and robust analysis framework able to predict the mode of action (MoA) of novel drugs and to identify drug re-positioning opportunities, by using gene expression data only.By using this framework I have been able to correctly predict a previously unreported effect for an existing (and approved) drug.

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  Embl - ebi & wellcome trust sanger institute

  Mar 2011 - Oct 2014

  Ebi & sanger post-doctoral (espod) fellow

  - Design and implementation of an integrative network-based framework to predict drug sensitivity in cancer- Design of computational models for drug re-purposing- Implementation of original Bioinformatics tools for the analysis of gene expression data- Study of gene regulation and protein-protein-interaction models with tools from complex network theory to infer primary causes of transcriptional changes (i.e. drug targets and/or endogenous perturbations) and crucial biological pathways (i.e. causal reasoning) Show less

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  Open targets

  Oct 2014 - Dec 2017

  Senior bioinformatician

  Development of tools for the statistical analysis of large-scale genome-wide CRISPR-Cas9 knock-out screenings data, to the aim of identifying synthetic lethalities in cancer.

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  Wellcome trust sanger institute

  Jan 2018 - Jul 2020

  Principal staff scientist - cancer depmap analytics team leader

  Development of new algorithms and computational tools for integrative analyses of large-scale cancer genomics and functional genomics datasets.The aim of this work is to identify molecular markers of drug response and new oncology therapeutic targets.Designing new analytical methods and software, and delivering scientific projects toward the definition of a Cancer Dependency Map: An atlas of genetic dependencies and vulnerabilities, at individual cancer cell resolution, which could be exploited for the development of targeted and personalized cancer therapies. Show less

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  Human technopole

  Oct 2019 - now

  • Research Group Leader

    Aug 2020 - now

  • Research Group Leader in Computational Biology

    Oct 2019 - Jul 2020