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Pierre Charlesworth

Pierre Charlesworth

Marie Skłodowska-Curie PhD fellow

Followers of Pierre Charlesworth345 followers
location of Pierre CharlesworthMilan, Lombardy, Italy

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  • Timeline

  • About me

    MSCA PhD researcher | Biotechnology | Microbiology | Synthetic Biology

  • Education

    • Università degli Studi di Milano

      2023 - 2026
      Doctor of Philosophy - PhD Cell/Cellular and Molecular Biology

    • SRUC

      2017 - 2021
      Bachelor of Science - BSc Agricultural Bioscience First Class Honours

      During my time completing this Bachelor’s with honours degree, I was introduced to a wide range of disciplines and experimental techniques. Both plant-centric and animal physiology & disease modules were taught during the course, but I specialised in my third and fourth years in microbiology and molecular fields.Honour's thesis: Garlic extract nanoemulsion: antibacterial properties under thermal and physicochemical environment stress

    • University of Glasgow

      2021 - 2022
      Master of Science - MSc Biotechnology Distinction

      Experience gained during the course of this Master's degree included: work focusing on the damaging effect of doxorubicin on MCF-7 cells, antibiotic screening of soil-based Streptomyces species with identification via 16S RNA, development & application of Light-Oxygen-Voltage (LOV) photoswitches for gene regulation & reporting, and development of a CRISPR/Cas9 knock-out/knock-in strategy to disrupt VEZF1 in HEK293 cells.Master's thesis: Faster photocycle kinetics in barley (Hordeum… Show more Experience gained during the course of this Master's degree included: work focusing on the damaging effect of doxorubicin on MCF-7 cells, antibiotic screening of soil-based Streptomyces species with identification via 16S RNA, development & application of Light-Oxygen-Voltage (LOV) photoswitches for gene regulation & reporting, and development of a CRISPR/Cas9 knock-out/knock-in strategy to disrupt VEZF1 in HEK293 cells.Master's thesis: Faster photocycle kinetics in barley (Hordeum vulgare) phototropin 2 LOV2 through engineering of key amino acid residues Show less

  • Experience

    • BREAKthrough_DN

      Jul 2023 - now
      Marie Skłodowska-Curie PhD fellow

      I am currently part of the EU-wide project BREAKthrough, working on investigating methods of destabilising the outer membrane of Gram-negative bacteria, in the context of re-sensitising multidrug resistant pathogens to existing antibiotics.BREAKthrough, a new Europe-wide Doctoral Network funded within the Marie Skłodowska-Curie Actions (MSCA) framework, will take on the most notorious type of superbug, Gram-negative bacteria, whose cell envelope (“walls”) prevent antibiotics from entering. The research aims to damage the cell envelope so that it no longer forms an obstacle and enables antibiotics to pass through and kill the bacterial cell. To develop novel compounds that can do this, BREAKthrough brings together experts from both academia and industry, covering fields like bacterial genetics, biophysics, cell biology, organic chemistry, pharmaceutical chemistry, and biochemistry. The project’s outcomes will have a significant scientific and societal impact: not only will the new compounds open up new avenues for developing new antibiotics, but they can also form new effective treatments through synergy with already existing antibiotics. Show less

  • Licenses & Certifications

    • Illumina MiSeq training

      Illumina
      Nov 2023

    • Illumina DNA Prep training

      Illumina
      Nov 2023

  • Honors & Awards

    • Awarded to Pierre Charlesworth
      The SRUC Trust Prize SRUC Aug 2021 Best Fourth Year Student for Agricultural Bioscience
    • Awarded to Pierre Charlesworth
      The Watson Peat Trophy SRUC Aug 2021 Best student at the Ayr Campus

  • Volunteer Experience

    • Farm volunteer

      Issued by Federation of WWOOF Organisations (FoWO) on May 2017
      Federation of WWOOF Organisations (FoWO)Associated with Pierre Charlesworth

    • Farm volunteer

      Issued by Federation of WWOOF Organisations (FoWO) on Oct 2016
      Federation of WWOOF Organisations (FoWO)Associated with Pierre Charlesworth