Somiranjan Ghosh

Experience

• 

  University of Calcutta

  Apr 1999 - Aug 2003

  Research Associate

  • Member of a team developing potential drugs from the Indian Ocean.• Isolation of a toxic principal compound (covalent like association between TTX and peptide) from world’s dreaded species “The Puffer”.• Obtain a PATENT for an innovative and simple technique towards isolation of PUFA enriched edible fish oil from these toxic fishes manifesting a hypolipidemic activity.

• 

  National Cancer Institute, NIH, Bethesda, MD

  Aug 2003 - Aug 2004

  Post-Doctoral Visiting Fellow

  • Lead a project and successfully identified molecular mechanisms involved in the effect of anti-cancer drugs in prostate and mammary tumorigenesis. • Established the drug effect (Perifosine, 17-dMAG, and Adaphostin alone or in combinations) on cell cycle regulatory proteins, enzymatic activity, and level of protein expression. • Generated stable resistant cancer cell lines to study the mechanistic basis of drug resistance to the cancer cell, which can be a landmark in the clinical development in anti-cancer drug studies. Show less

• 

  Howard University

  Sept 2004 - now

  I am striving to create a foundation that will advance the identification and understanding of the role of environment in human health and disease, provide fresh perspectives, and bring new understanding to problems in environmental health through application of innovative knowledge and problem-solving. The goal of my research is as follows: if the chemical's interactions that are related to the obesity epidemic are identified, and removed from products that are the primary contributors to human exposures, there would be the reason to hope that the current trend of increasing obesity and diabetes can be reversed. Show less • Design research and bench level experiments to address the role of chemical exposures in the context of diseases and disorder development in humans.• Established a complex in vitro model system (Human-PBMC) to demonstrate the role of Polychlorinated biphenyls (PCBs) in modulating pathway specific disease development by the application of Microarray gene expression and Ingenuity Pathway analysis.• Developed validation of early disease biomarkers in a High-throughput way (TLDA) through a population based studies.• Supervising Ph.D. students in the lab. Show less

  • Associate Professor

    Jul 2022 - now

  • Assistant Professor

    Jul 2015 - now

  • Assitant Professor

    Jul 2015 - now

  • Principal Investigator, NIMHD/NCI Projects

    Sept 2004 - now