Ananda Rajkumar K

Experience

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  Intas Pharmaceuticals

  May 2001 - Mar 2003

  Research Associate

  1. Method development for analysis of photosensitizer in the treated protein – HPLC and validation of the method.2. Standardization of Viral Inactivation Procedures: Photoinactivation was developed successfully so that the resultant protein retained its maximum functional integrity to a maximum and novel level. 3. Standardization of dissolution medium of the protein to get the optimal requirements as per BP.4. Standardization of stabilizer medium of the protein for withstanding Dry heat method of viral inactivation.5. Product validation with Solvent – Detergent Method of Viral Inactivation – HPLC. Show less

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  Sanmar Speciality Chemicals Research Centre Private Limited

  Mar 2003 - Jun 2004

  Officer-QC

  1. Active Responsibility in installation of NMR facility Bruker Avance 400 & performing various NMR analytical techniques starting from proton, 13C and special experiments like COSY, DEPT, & 1D NOE etc., Regular maintenance like LN2 Filling, coordinating for L He filling, etc.,2. Analytical method developments for new compounds - HPLC and GC.3. Routine Analysis involving GC and HPLC methods for APIs, process intermediates, raw materials and finished products.4. Calibration of HPLC and GC systems. 5. IR, UV & Wet analysis of various intermediates, finished products, raw materials. Show less

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  Chembiotek Research International Private Limited

  Jun 2004 - Aug 2005

  Research Chemist

  1. A team member in Impurity profiling – given responsibilities are: method development for Preparatory HPLC Separations of the impurities and their NMR Characterization.2. Analytical method developments for new compounds by HPLC (UV and ELS Detectors); Preparatory HPLC separations of Compounds and impurities & routine analysis by HPLC.3. Active Responsibility in performing various NMR analytical techniques starting from proton, 13C NMR; special experiments like COSY, DEPTs, & 1D NOE etc., and Regular maintenance like LN2 Filling, coordinating for L-He filling.4. Polarimetric analysis of various compounds.5. Calibration of HPLC systems, maintenance of HPLC systems and maintaining data backup. Show less

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  Orchid Pharma

  Aug 2005 - Sept 2007

  Research Executive

  Role: • Lead member in Impurity isolation and characterization – given responsibilities are: method development for Prep HPLC Separations and isolation of the impurities and their NMR Characterization using 1H, 13C NMR, 2D experiments like COSY, HMBC and HSQC.• Routine NMR analysis – 1H, 13C NMR, and special experiments like HMBC, HSQC, VT NMR and NOE experiments on requirement basis.Accomplishments Successfully isolated and characterized several impurities. Successfully characterized them with MS supporting data, and by NMR along with some other characterization of about 10 API molecules and their intermediates. Show less

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  Jubilant Biosys Limited

  Mar 2008 - Feb 2013

  Senior Research Scientist

  Role:• To manage analytical services in the area of Preparative HPLC, NMR, UPLCMS, UHPLCMS and LCMS.• To share the load of the fellow scientist in managing HPLC and other analytical areas.Accomplishments Consistent management of on time delivery of results from NMR and Prep. HPLC purified compounds with minimal break up time in the current assignment.  Structural elucidations for more than 500 compounds by 2D NMR and other special experiments

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  Novartis

  Feb 2013 - now

  Role:• Team lead – 16-member team of API & Drug product analytics team involving in various NCE development analytics (LCs, DRs, titrations) in GMP environment. • Team lead (01-Sep-2017 to 28-Feb-2020) -15-member team of specialty analytics – PXRD, DSC, TGA, FTIR, PSD, and GC group.• Led the team and act as an Analytical expert for various analytical projects on going across global sites for solid state characterization.• Acted as the subject matter expert for XRPD, Thermal analytical techniques, Expert for FTIR and NMR spectroscopy.• To co-ordinate with the Global teams and responsible for solid state characterization and stability analytics by the team for various projects.Accomplishments Led a project on LCMS D2O online exchange for structure identification of impurities with NIPER A, as a part of Industry Academia collaboration initiative by GDD India. As a part of the same initiative capability exchange sessions with various NIPERs and MAHE were completed in 2022-23. The work is published in Analytical Chemistry Letters, 14:2, 170-177. TRD Culture Core team member and culture ambassador for ARD for the culture aspirations of Novartis. Collaborating with Site and Global LT on developing fruitful actions based on various employee engagement surveys. Successful embracing of the new role as a team lead for a projects team from core specialty analytics area; gathering people trust and successful on time deliverables for various IMPD/IND submission relevant analytical activities even at COVID- 19 pandemic situation. Leading the team for consistent on time delivery of results for the handled projects. Show less Role:• Analytical expert for assigned projects on going across global sites 2013-2014.• To act as an analytical expert for Titrations, XRPD, TGA, DSC and PSD.• To act as the subject matter expert for IR and NMR spectroscopy for IndiaAccomplishments Establishment of the PXRD facility in GMP environment, onsite transfer of various late phase project activities from global site. Consistent management of on time delivery of results for the handled projects.  Method development and validation for more than 25 NCEs in a year for titration methods for assay and water content, and FTIR spectroscopic methods for various activities. Show less

  • Senior Manager Oral projects

    Apr 2017 - now

  • Principal Scientist

    Feb 2013 - Mar 2017