Pierre Taraconat, PhD

Education

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  Université de Montpellier

  2016 - 2020

  Doctor of Philosophy - PhD mathematics and modeling

  In Coulter counters, cells counting and volumetry is achieved by monitoring their electrical print when they flow through a polarized micro-orifice. However, the measurements may be impaired when the trajectory of the cell is in the vicinity of the aperture edges due to complex dynamics and deformations of the cell. In this thesis, numerical simulations of the dynamics and electrical signature of red blood cells (RBCs) in a Coulter counter are presented. In particular, a specific numerical… Voir plus In Coulter counters, cells counting and volumetry is achieved by monitoring their electrical print when they flow through a polarized micro-orifice. However, the measurements may be impaired when the trajectory of the cell is in the vicinity of the aperture edges due to complex dynamics and deformations of the cell. In this thesis, numerical simulations of the dynamics and electrical signature of red blood cells (RBCs) in a Coulter counter are presented. In particular, a specific numerical pipeline is developed. This numerical pipeline is used with rigid spheres and deformable RBCs in an industrial Coulter counter and compared with experimental results. The simulations not only reproduce electrical signatures typical of those measured experimentally, but also provide an understanding of the key mechanisms at play. The impact of the cell morphology and rheology on the electrical print is evidenced. Furthermore, neural network modellings are performed for assessing such RBC properties. Voir moins

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  Polytech Montpellier

  2011 - 2016

  Diplôme d'ingénieur Engineering Mechanics