Ramesh Ray, Ph.D.

Experience

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  Sardar Patel University

  May 1984 - Jan 1993

  Lecturer in Microbiology/ Reader (Cell Biology)

  Research & Teaching:Research: Fermentation and bio-transformation. Immobilization of enzymes for the production of biochemicals.Teaching:Taught Microbial Physiology; Microbial Genetics; Cell and molecular Biology, Medical microbiology, Genetics of bacteria and viruses and Industrial Microbiology courses and respective laboratory courses for the postgraduate students (Sardar Patel University, India). Taught medical Laboratory Technology (MLT) courses at Mahagujarat Hospital (Nadiad, India). Assisted in accreditation of Mahagujarat hospital laboratory by Indian Medical council. Show less

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  University of Florida

  Jan 1993 - Jan 1996

  Biological Scientist

  conducted research on 1) cloning and expression of Cellulase gene from methanogenic bacteria and 2) regulation of molybdate transport in E.coli.

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  University of Tennesse Health Science Center

  Oct 1996 - Dec 2015

  Instructor/Assistant/Associate Professor

  Contributions: • As Co-PI on NIH-funded grants for past 15 years, I have laid the foundation for the research in GI epithelial homeostasis. We delineated the molecular mechanism by which spermine regulates integrin-mediated signal transduction and dynamic remodeling of cytoskeleton organization necessary for cell migration during epithelial wound healing. I began investigating the role of polyamines in the gut homeostasis. At the time, it was generally believed that upon depletion of polyamines growth stops simply due to a decrease in the expression of oncogenes. However, we showed that polyamine depletion stimulated negative regulators of cell cycle like p21waf1 and p27kip1 to inhibit cell cycle and prevented cell death by stimulating anti-apoptotic signaling pathways. We deciphered the role of polyamines in the regulation of cell growth through the control of p53-mediated cycle regulators and their role in the apoptotic signaling cascade.We demonstrated the involvement of mTOR pathway in the regulation of AZ protein synthesis following spermidine-mediated +1 ribosomal frameshifting. Show less

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  The University of Tennessee Health Science Center

  Aug 2017 - now

  • Senior Biological Safety Officer

    Jul 2023 - now

  • Institutional Biosafety Officer

    Aug 2017 - now