Azadeh Mostafavi

Experience

• 

  Royan Institute

  Jan 2013 - Jan 2016

  Graduate Research Assistant

  • Developed a highly tough and self-healable dual physically crosslinked sulfated alginate-based polyurethane elastomers for vascular tissue engineering.- Synthesised and characterized the physical and mechanical properties of the polymer.- Analysed the anticoagulation activities of the polymer to prevent blood clotting and platelet adhesion to the scaffold.- Isolated HUVEC cells from the umbilical cord and evaluate the improvement of the cultured cells on the polymer.- In vivo evaluation of body reaction to the synthesized polymer.Supervisors: Professor Hossein Baharvand and Dr.Sara Rajabi Show less

• 

  University of Nebraska-Lincoln

  Jan 2018 - May 2021

  Graduate Research Assistant

  • Improved muscle regeneration and vascularization through in vivo printing of growth factor-loaded nanoengineered material in volumetric muscle loss animal models (VML). - Improved in vitro differentiation of myoblasts to myotubes by aligning cells through 3D bioprinting technique.- Enhanced HUVECs functionality by controlling the release of growth factors (VEGF) from loaded nanoparticles (Laponites) to improve vascularization in VML injuries. - Improved the skeletal muscle regeneration in volumetric muscle loss mouse animal models using in vivo printing of loaded nanoengineered hydrogel (a collaboration work with Brigham hospital, Boston).- Contributed to the development of a handheld 3D printer for in vivo printing of soft materials.• Bone tissue regeneration by developed a new approach for in situ printing of micro-engineered osteoconductive hard material.- Introduced an in situ printable osteoconductive PCL-based biomaterials and evaluated it's in vivo body reaction.- Enhanced the differentiation of hMSC to osteoblasts using an osteoconductive material (HAp).• Evaluated the effect of nanoelectrospined liquid crystal fibers scaffold on improving the differentiation of the skeletal muscle cell.Supervisor: Dr.Ali Tamayol Show less

• 

  University of California, Los Angeles

  Jan 2020 - May 2021

  Visiting Graduate Researcher

  • Significantly improved soft tissue regeneration and vascularization in vivo through developing a new porous bioink for 3D bioprinting the tissue structures.Supervisors: Dr.Ali Tamayol and Dr.Nasim Annabi

• 

  Orbillion Bio (YC W21)

  May 2021 - now

  • Patented an innovative concept in 3D-based cell culture.• Developed animal tissue-derived cell lines (Primary satellite and adipocyte cells) - Carried out muscle cell organoid formation in suspension culture to establish a scalable system.- Worked on the proliferation and differentiation media formulation for muscle cells and improved the percentage of cell differentiation and tube formation.• Worked with various collaborator companies across the world to evaluate their microcarrier products as a solution for scaling up cell production.• Worked closely with the bioprocessing group and evaluated media formulations, cell metabolic activities, and microparticles for muscle cell expansion in microcarrier-based spinners, and shaker suspension culture platforms.• Led the project on the fabrication of the dissolvable microcarriers and evaluated their efficacy in suspension culture which simplified the cell harvesting process.• Introduced and led the production of the cultivated meat patty burger from an edible scaffold (cultured with cells) at Orbillion. Show less

  • Senior Scientist - Cell line development, Bioprocess development and tissue engineering

    Oct 2022 - now

  • Scientist- Cell line development and tissue engineering

    May 2021 - Oct 2022