Brian I. Bliss, Ph.D.

Brian I. Bliss, Ph.D.

United States Marine

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  • Timeline

  • About me

    Pharmaceutical Manufacturing Leadership | Research & Discovery | Process & Operational Excellence | Lean Six Sigma Black Belt

  • Education

    • University of Maryland

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      Associate of Arts - AA Sociology
    • Rochester Institute of Technology

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      Bachelor of Science - BS Chemistry (ACS Certified)

      Activities and Societies: BS conferred with Highest Honors. American Chemical Society (ACS) Certified Course of Study, Alpha Chi Sigma Professional Chemistry Fraternity, Phi Kappa Phi National Honor Society.

    • The Ohio State University

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      Master of Science - MS Organic Chemistry

      Activities and Societies: Thesis: Cinchona Alkaloids as Chiral Catalysts in the Baylis-Hillman Reaction: Adviser: Prof. V. Rawal.

    • The Ohio State University

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      Doctor of Philosophy - PhD Organic Chemistry

      Activities and Societies: Dissertation: Studies in Free Radical Chemistry. Advisor: Prof. T.V. Rajanbabu. My doctoral work in Professor Rajanbabu's group at OSU involved the application of mild and selective free radicals to the synthesis of functionalized cyclobutanes (e.g. AZT). During this work, an unexpected pathway was observed leading to novel N-furanosides and N-glycosides. This discovery opened up a novel approach (i.e. methodology) to a wide variety of other structures of chemical/therapeutic interest. For detailed description and impact of my dissertation work, see: Rhee, J. U.; Bliss, B. I.; RajanBabu, T. V. “New reaction manifold for the Barton radical intermediates: synthesis of N-heterocyclic furanosides and pyranosides via the formation of the C1-C2 bond.” J. Am. Chem. Soc. 2003, 125, 1492. Rhee, J. U.; Bliss, B. I.; RajanBabu, T. V. “Stereochemical control in radical cyclization routes to N-glycosides: role of protecting groups and of the configuration (E vs. Z) of the acceptors,”… Show more For detailed description and impact of my dissertation work, see: Rhee, J. U.; Bliss, B. I.; RajanBabu, T. V. “New reaction manifold for the Barton radical intermediates: synthesis of N-heterocyclic furanosides and pyranosides via the formation of the C1-C2 bond.” J. Am. Chem. Soc. 2003, 125, 1492. Rhee, J. U.; Bliss, B. I.; RajanBabu, T. V. “Stereochemical control in radical cyclization routes to N-glycosides: role of protecting groups and of the configuration (E vs. Z) of the acceptors,” Tetrahedron: Asymmetry 2003, 14, 2939. Show less

  • Experience

    • United States Marine Corps

      Jul 1984 - Sept 1989
      United States Marine

      I answered the call to serve after the Beirut Bombing of the Marine Barracks in 1983, enlisting in the Infantry in May of 1984. My family and hometown has a long, distinguished, and respected line of veterans spanning WWII, Korea, Vietnam, and War on Terror. Service was an honorable, noble, and apolitical duty to our community and our country. Home of Record: St. Albans, Vermont.1) Career Field: Infantry - TOW Anti-Armor Missileman (MOS0352), Infantry Training School, Camp Lejeune, NC. Temporary Additional Duties at Headquarters, Marine Corps followed by assignment to HQ Company, 5th Marines, 1st MarDiv (Rein), Camp Pendleton, CA. 1984–1986. Deployed to Mountain Warfare Training Center (MWTC), Bridgeport, CA with Weapons Co., 3rd Bn 5th Marines. 2) Career Field: EOD - Voluntary lateral move to Explosive Ordnance Disposal (EOD) (MOS2336). Completed EOD training at US Naval School EOD, Indian Head, MD and U.S. Army Ordnance Missile and Munitions School, Redstone Arsenal, AL followed by assignment to EOD Team, 1st Marine Air Wing, Marine Corps Air Station, Iwakuni, Japan 1986-1989. EOD Technician are experts in the safe location, identification, recovery, rendering safe and destruction of hazardous conventional, improvised, chemical, biological and nuclear ordnance and munitions, and the safe recovery and disassembly of foreign ordnance and munitions for technical intelligence value. ❖ Held military positions of high trust and responsibility❖ Military Clearance: SECRET ❖ Access: Critical Nuclear Weapons Design Information (CNWDI) ❖ Navy/Marine Corps Personal Reliability Program (PRP)MILITARY EDUCATION Non-Commissioned Officer Leadership Course, Marine Corps Air Station, Iwakuni, Japan 1987Separated from Active Duty October 1989: Sergeant (E-5). Character of Service 1984-1989: HONORABLE. Notarized copies of DD214 will be available for review during interview. Show less

    • United States Marine Corps

      Jan 1991 - Jun 1991
      United States Marine

      Recalled to Active Duty from Rochester Institute of Technology for six months in support of Operation DESERT STORM. Assignment: Explosive Ordnance Disposal (EOD) Team (MOS2336), Range Company, 2 FSSG, 2nd MarDiv, Camp Lejeune, NC. Rank upon separation: Staff Seargent (E-6). Character of Service: HONORABLE. Discharged from military service: July 1992.

    • Rensselaer Polytechnic Institute

      May 1999 - Jun 2000
      Postdoctoral Researcher

      Investigated application of the Schultz asymmetric Birch alkylation methodology toward the preparation of selected members of the quinolizidine and indolizidine family of alkaloids, including (+)-lupinine and (-)-5-epitashiromine, respectively. Advisor. A. Schultz

    • Curia

      Jun 2000 - Jan 2011

      Coach, mentor and lead a contract research medicinal chemistry project team for a major US pharmaceutical company customer satisfying their expectations, research goals and objectives and Curia financial objectives. Directed the independent research efforts of a group of 3 medicinal chemists and managed an $800K contract research project. Direct involvement in managing and servicing customer internal research and discovery relationships and a track record of assisting customers establishing intellectual property positions, patent support and advancing lead compounds to clinical evaluation. Proposed and executed innovative, practical, novel, “Value-Added” solutions to project technical problems and directions for future research. Proficient at quickly changing work focus and direction and incorporating new knowledge and areas of expertise. Daily laboratory oversight of scientific staff. Supervised scientific research results and focus to align with customer and project objectives. Authored weekly research updates and scientific manuscripts. Skilled, resourceful and effective public presenter and speaker. Show less Curia, f/k/a Albany Molecular Research (AMRI), is a pioneer and leader in Contract Research Organization providing Full-Time Equivalents (FTE's) to the pharmaceutical industry. Contract medicinal chemistry services in the synthesis and characterization of compounds of medicinal and pharmaceutical interest in a wide array of therapeutic areas including oncology, infectious diseases, CNS disorders, cardiovascular diseases, inflammation, diabetes and ocular disorders. Proposed and executed innovative, practical, novel, “Value-Added” solutions to customer’s technical problems and proposed directions for future research (e.g., Bliss et al, Tetrahedron Letters 2010, 51, 3259). Skilled at quickly changing work focus and direction and incorporating new knowledge into current areas of expertise. A successful track record of assisting customers establishing intellectual property positions, patent support and advancing lead compounds to clinical evaluation. Show less

      • Group Leader - Medicinal Chemistry

        Jan 2009 - Jan 2011
      • Senior Research Chemist

        Jun 2000 - Jan 2009
    • Curia

      Mar 2011 - Sept 2021

      Promoted to organize, optimize, lead and transform underperforming commercial and developmental manufacturing areas to operational efficiency and profitability to meet the changing demands of the pharmaceutical industry, customer expectations and Curia strategic objectives. Lean Six Sigma Manufacturing methodology across every aspect of manufacturing area of responsibility in the management and oversight of two (2) manufacturing areas containing eight (8) manufacturing trains, 25-30 labor and 4 supervisory work force to drive schedule attainment, increase productivity and quality compliance, reduce human errors and process failures, promote cost savings, increase absorption, increase revenue and EBIDTA objectives. Show less Promoted to organize, optimize, lead and transform underperforming commercial and developmental manufacturing areas to return these units to operational efficiency to meet the changing demands of the pharmaceutical industry, customer expectations and Curia strategic objectives. Created and sustained a culture of goal-oriented alignment of Team output with corporate objectives, established and consistently communicated high expectations of individual performance/accountability and pharmaceutical operational excellence. High impact, rigorously supported written Quality Exception/Failure Investigations, technical reports, quality risk/impact assessments, updates and summaries for the benefit and use of internal/external customers. Show less

      • Operations Manager - High Potency and Developmental (GMP) Manufacturing.

        Jan 2019 - Sept 2021
      • Operations Manager - Large Scale Commercial Manufacturing (API).

        Jan 2017 - Jan 2019
      • Technical Services Chemist - Commercial Manufacturing (API)

        Mar 2011 - Jan 2017
    • Mallinckrodt Pharmaceuticals

      Sept 2021 - Apr 2023
      Manufacturing Focus Factory Manager

      Supervised, managed and provided leadership over the collective performance of all manufacturing departments – Blending, Tableting and High Volume Plant (HVP) – staffed three shifts five days a week. Manufacturing staffed by approximately 80+ production technicians, 5 supervisory, 3 Process Engineers, and 2 Quality support personnel. Job responsibilities included, but were not limited to, the following: Coordinating manufacturing capabilities and capitalizing on emerging opportunities with Planning to maximize monthly and quarterly productivity and financials targets in response to changing commercial demand, staffing and raw material constraints. Show less

    • Purdue University Online

      Jun 2023 - Mar 2024
      Lean Manufacturing + Six Sigma Black Belt Professional Development

      Building upon successful and practical experience employing Lean and Six Sigma methodologies between 2017–2023, I elected to take a 10-month professional sabbatical for mastery of Lean Six Sigma principles through Purdue University’s College of Engineering. Staying current with global business best practices, I chose Purdue University based upon its international reputation and the breath, depth and rigor of its LSS BB certification program.• Lean Six Sigma Certification - Black Belt Oct 2023–Mar 2024• Lean Manufacturing Certification Jul 2023–Sep 2023• Lean Six Sigma Certification - Green Belt Jun 2023–Aug 2023 Show less

  • Licenses & Certifications

    • Lean Six Sigma Black Belt

      Purdue University Online
      Mar 2024
    • Lean Principles Certification

      Purdue University Online
      Sept 2023
    • Lean Six Sigma Green Belt

      Purdue University Online
      Aug 2023
  • Volunteer Experience

    • Head Coach - Master (Level V)

      Issued by USA Hockey on Aug 1986
      USA HockeyAssociated with Brian I. Bliss, Ph.D.
    • Advanced High School Chemistry Course Mentor

      Issued by Duanesburg Central Schools on Oct 2013
      Duanesburg Central SchoolsAssociated with Brian I. Bliss, Ph.D.