Melanie Galvin

Experience

• 

  Covance

  Feb 2006 - Sept 2006

  Laboratory Scientist

  Performed all aspects of histology primarily on rodent oncology studies.

• 

  AstraZeneca - Histology and Necropsy Unit

  Dec 2006 - Feb 2012

  Scientist

  Performed all aspects of histology/necropsy including Schedule 1 procedures, animal handling, halothane euthanasia, vena cava blood sampling and necropsy of rodents, as well as tissue fixation, trimming, processing, embedding of both rodent and non-rodent tissues into paraffin wax, microtomy and haemotoxylin and eosin staining. Significant experience in special staining techniques including Periodic Acid Schiff, Gram, and Perls Prussion Blue.

• 

  AstraZeneca - Investigational and Translational Pathology

  Feb 2012 - Nov 2013

  Scientist

  Performed routine and more complex immunohistochemistry with minimal direction, routine image analysis on Aperio ScanScope using positive pixel and colour deconvolution algorithms. Experience in electron microscopy processing and semi-thin sectioning, Western Blotting techniques, Bright Field and Confocal Microscopy and In-situ Hybridisation.

• 

  Cancer Research UK Manchester Institute

  Jan 2014 - now

  Manage Preclinical Pharmacology in vivo Team - reporting to the Preclinical Pharmacology Associate Scientist:• Develop and maintain mouse models of cancer (Circulating Tumour Cell derived explant/CDX models), specifically Small Cell Lung Cancer• Project management of all in vivo studies conducted within CEP, including collaborations with other academic institutes and pharmaceutical companies.• Supervise small, medium and long term in vivo studies supporting PhD students and Post-Doctoral Scientists within the group.• Alternative Contact (Deputy) on Home Office Project Licence, designing and writing protocols ensuring all aspects of the project design are covered by the PPL; co-ordinate animal orders and completing Home Office Returns for CEP in vivo studies.• Carry out data analysis for all in vivo efficacy/pharmacodynamics studies, presenting findings to group leaders/senior scientists/peers, as well as at both internal and external meetings.• Manage a team of 6 in vivo technicians, conducting regular 1-2-1 meetings, encouraging their development and ensuring they are receiving as much training as possible to achieve their individual goals.• Collaborate with other groups within the institute, supervising/assisting with training in specialist techniques/protocols.• Effectively troubleshoot problems through proactive liaison with other in vivo technicians and Senior Scientists.• Active member of the CRUK MI AWERB, working to refine animal use within the Institute. Show less Reporting to in vivo team leader; manage small, medium and long term in vivo studies supporting PhD students and Post-Doctoral Scientists within the group.• Fully competent to carry out a wide range of in vivo techniques including drug dosing, cardiac puncture, surgical techniques, necropsy, animal handling and general day to day care of the animals.• Improve knowledge and experience of staff by training and supervising a number of in vivo techniques ensuring Home Office guidelines are adhered to.• Effectively troubleshoot problems through proactive liaison with other in vivo technicians and Senior Scientists.• Successfully complete concurrent projects within tight deadlines because of exceptional time management skills, producing detailed data analysis and reports.• Continually look to increase knowledge by attending seminars, journal clubs and reading recently published papers.• Active member of CRUK MI 3Rs Network, working to refine animal use within the Institute. Show less

  • Service Manager 1

    Nov 2020 - now

  • Senior Scientific Officer

    Sept 2015 - Nov 2020

  • Scientific Officer

    Jan 2014 - Sept 2015