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Manisha Kalsan

Manisha Kalsan

Trainee

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location of Manisha KalsanNew Delhi, Delhi, India

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  • Timeline

  • About me

    PhD in Computational Biology and Bioinformatics | R programming | Machine Learning | DNA shape | NGS | Computational Genomics | TF-DNA Interactions

  • Education

    • Pratap Public School, Karnal

      2006 - 2008

    • Tagore Baal Niketan Sr Sec School, Karnal

      1998 - 2006

    • Jawaharlal Nehru University (JNU)

      2016 - 2017
      Pre PhD Computational Biology and Bioinformatics

      Subjects covered: Genomics, Information Theory, Quantitative methods, Data modelling and algorithms

    • Delhi Technological University (Formerly DCE)

      2012 - 2014
      Master's Degree Bioinformatics

    • Delhi Technological University (Formerly DCE)

      -
      Master of Technology - MTech Bioinformatics

    • Jawaharlal Nehru University (JNU)

      2017 - 2024
      Doctor of Philosophy (Ph.D.) Computational Biology and Bioinformatics

      My work focussed on the applications of DNA conformations based DynaSeq dictionary as a tool to understand TF-DNA interactions highlighting the distinct binding preferences of TFs from same family (HOX TFs) despite their similar sequence preferences; characterizing TF classes (pioneers, migrants and settler TFs) defined based on their chromatin opening property and relating these TF classes with the temporal binding of a TF (Fast and Slow sites). My work also involved studying the… Afișați mai multe My work focussed on the applications of DNA conformations based DynaSeq dictionary as a tool to understand TF-DNA interactions highlighting the distinct binding preferences of TFs from same family (HOX TFs) despite their similar sequence preferences; characterizing TF classes (pioneers, migrants and settler TFs) defined based on their chromatin opening property and relating these TF classes with the temporal binding of a TF (Fast and Slow sites). My work also involved studying the conformational deformations of DNA structures and exploration of clusterable DNA shape states with an aim to understand their role in explainability of the TF binding events generated in vivo. Afișează mai puține

    • Deenbandhu Chhotu Ram University of Science and Technology (DCRUST), Murthal

      2008 - 2012
      Bachelor of Technology (B.Tech.) Biotechnology

  • Experience

    • National Dairy Research Institute

      Jan 2010 - Jan 2010
      Trainee

    • Deenbandhu Chhotu Ram University of Science and Technology (DCRUST), Murthal

      Jan 2011 - Aug 2011
      Trainee

      Microbiological water sample testing, bacterial cell culture

    • Delhi Technological University (Formerly DCE)

      Jan 2014 - Jan 2016
      Junior Research Fellow

      Literature surveys for the concepts of stem cells and their potencies, the reprogramming of somatic cells to generate iPSCs and their differentiation into cells of interest for the treatment of degenerative diseases. My work also involved documenting my surveys as reviews which were published as three review papers. The research group mainly focussed on generation of Red Blood Cells using iPSCs and hence, the standardization of the protocol for the same was of prime importance. During this I got familiarized with different experimental methods that are carried out in an animal cell laboratory. Afișează mai puține

    • INMAS, Defence Research and Development Organization (DRDO)

      Mar 2014 - Aug 2014
      Trainee

      Homology Modelling, Docking, Virtual screening, Chem-informatics, bioinformatics, molecular modelling

    • ISCB-SC RSG-India

      Sept 2017 - Feb 2022
      Secretary

      RSG-India is the face of the ISCB-SC's RSG initiative in India. With students from different levels of education (undergraduates to postdocs) and different parts of the country, RSG-India represents a microcosm of the Indian computational life sciences student community. We organised several symposiums, conferences and competitions for the student community. We also focussed on different problems students/researchers face during transition between fields and choosing career positions in different sectors with opinions from experts from these sectors, and intellectual property rights in the field of computational biology and bioinformatics. Our recent webinars have tried to address important topics such as the mental health of the researchers, transition from computational and biological sciences to computational biology as well. Our focus remains to create more connections and better representation in the scientific community. Afișează mai puține

  • Licenses & Certifications

    • ICMR-JRF 2015

      ICMR

    • CSIR JRF (NET) 2015

      CSIR
      Jan 2015

    • GATE-BIOTECHNOLOGY-2012

      Indian Institute of Technology, Roorkee
      Mar 2012