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Faraz (Farazuddin) Mohammad
Reserach associate

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About me
Food allergy | Nano-therapeutics | Vaccine development
Education

Rahstriya Inter college
1996 - 2000Higher secondary Biology/Biological Sciences, General
Aligarh Muslim University
2006 - 2009Master's Degree Biotechnology 1stActivities and Societies: Master in Philosophy in Biotechnology major. I worked on dissertation entitled"Liposome based formulations of polyene antibiotics in the treatment of infections." My M Phil work was focused on development and surface modification of liposomal based formulations of polyene antibiotics. Polyene antibiotics are used against systemic infections and possess strong activity against infections like C. albicans and C. neoformans. But these antibiotics are associated with high hemolytic activity when used at high dosage. I developed phosphatidyl choline and cholesterol based liposome formulations. We did their surface modification using tuftsin. Tuftsin, is a… Show more My M Phil work was focused on development and surface modification of liposomal based formulations of polyene antibiotics. Polyene antibiotics are used against systemic infections and possess strong activity against infections like C. albicans and C. neoformans. But these antibiotics are associated with high hemolytic activity when used at high dosage. I developed phosphatidyl choline and cholesterol based liposome formulations. We did their surface modification using tuftsin. Tuftsin, is a immunomodulator and it boost immune cells when come in contact. Combination of tuftsin with liposomes encapsulating these antibiotics, enhances their efficiency in combating infections. These formulations were examined for in vitro toxicity and are shown to be non-toxic even when used at high dosage of encapsulated antibiotics. Further, they were found highly effective and non-toxic when used again systemic infections like Candidiasis and Cryptococcis in mice model. Show less

Aligarh Muslim University
2009 - 2012Doctor of Philosophy (Ph.D.) Oncology and Cancer Biology, nanotechnologyI developed poly-lactic glycol acid (PLGA) based nano particles of perillyl alcohol (POH), to encounter poor pharmakokinetics and pharmakodynamics associated with POH. I studied their efficacy in di methyl benzo anthracene (DMBA) induced skin papilloma. Developed nano particles were studied for their size and release kinetics of POH using HPLC. We studied reduction in tumor size, apoptosis using Western blot of Caspases, and survival of treated animals. Since PLGA nano particles were associated… Show more I developed poly-lactic glycol acid (PLGA) based nano particles of perillyl alcohol (POH), to encounter poor pharmakokinetics and pharmakodynamics associated with POH. I studied their efficacy in di methyl benzo anthracene (DMBA) induced skin papilloma. Developed nano particles were studied for their size and release kinetics of POH using HPLC. We studied reduction in tumor size, apoptosis using Western blot of Caspases, and survival of treated animals. Since PLGA nano particles were associated with burst release pattern, we tried to encapsulate them further in phosphatidyl choline (PC) liposomes to overcome burst release. This strategy allowed us to pass burst release pattern. Nano formulation encapsulating curcuming proven to be highly efficient in delivering it at slow rate. We tested its efficacy against hepatocellular carcinoma and they were found to suppress carcinoma. Show less

Bangalore University
2003 - 2005Master's Degree Biotechnology 1stMaters in Biotechnology as a major. Studied Biochemistry, molecular biology, immunology, biostatistics, bioethics and microbiology in 4 different sememsters
Experience

Molecular Connections
Aug 2005 - Aug 2006Reserach associateI worked on two different projects at Molecular connections. One project Immunex was focused on curating the immunological response data associated in different diseased conditions. Another project Proteome was focused on putting together the scientific literature associated with proteins that plays a major role in disease pathogenicity.

University of Illinois Chicago
Oct 2012 - Apr 2015Postdoctoral Research AssociateMy postdoctoral expertise added advancement to my skills. I workedon PTEN (phosphatase and tensin homolog), a tumor suppressor gene. I generated endothelial specific PTEN deleted mice. I confirmed the PTEN deletion via quantitative PCR and Western blotting of PTEN. Further I examined role of PTEN deletion in the mouse model. To address its role in acute lung injury, I used LPS-induced sepsis models. I demonstrated that the PTEN knock-out mice have a prolonged life span and they are resistant to sepsis. Further I studied lung endothelium integrity by means of Evans blue dye where I injected albumin-conjugated Evans blue retro-orbitally and measured its leak into lungs. I established that PTEN-deficient mice had protected lung endothelium. To explore the signalling mechanism responsible for this function, I studied Akt mediated signalling and cell proliferation using flow cytometry techniques. I also worked on several other projects with my colleagues focused on signalling in lung endothelium during sepsis. Show less

University of Michigan
Apr 2016 - nowAs a part of nanotechnology institute, I am trying to develop nanoemulsion based vaccine for mucosal immunization. I modified the nanoemuslion in a way that could boost the immune responses mucosal surface and helps in successful elimination of the pathogen. Currently, I am working on a nanoemulsion and its modification that could boost antibody responses as well as provides balanced Th1/Th2/Th17 responses for mucosal immunization.
Research Investigator
Oct 2021 - nowResearch Lab Specialist Senior
Jan 2019 - Oct 2021Post Doc Research Associate
Apr 2016 - Jan 2019

MiLEAD Consulting
Sept 2016 - Sept 2018Freelance Marketing ConsultantmiLEAD is a student/post-doc lead non-profit organization at University of Michigan. The objective of miLEAD is to train its members for non-academia jobs, help them understanding the demand of industry, navigation and acquiring those skills. At miLEAD, you get to work with students from different streams, learn to network and build in those skills. Working on a live project and presenting those strategies to your clients, gives you sense of working environment as well as job demands outside the academia. Show less

University of Michigan Postdoc Association
Jul 2019 - Sept 2019A Leadership and Management Program for PostdocsYou3 – A Leadership and Management Program for Postdocs is a structured program aimed at filling a critical need in postdoc professional development for current training and future career success. This program is designed by postdocs for postdocs under the guidance of OGPS’ Director of Curriculum and Educational Initiatives. Using statistical tools to analyze survey data and aligning them with pedagogical best practices, this program is structured as eight 1.5-hour weekly modules to develop mastery in three aspects of management and leadership. These modules, organized below, will be facilitated by topic experts. The program will be enriched with effective tools and case-studies to provide learning opportunities for participants. Show less

Innovation Partnerships
Sept 2020 - Dec 2020Biomedical Innovation & Entrepreneurship (I & II)Biomedical Innovation & Entrepreneurship I and II is a credit bearing course intended for graduate students* and post doctoral fellows from science and engineering majors who are seeking insight for those who are seeking a career in the biomedical industry and exposure to the fundamentals of life science entrepreneurship.Course is uniquely designed students looking for:1. A career in biomedical industry2. Insight into life science entrepreneurship3. A roadmap for technology commercialization or product development Show less
Licenses & Certifications
- View certificate

Science Communication Fellow
University of MichiganApr 2021 
FFMI fast pace
U-M Office of Technology TransferSept 2018- View certificate

Biotech Career Development Program
U-M Office of Technology TransferMar 2020 - View certificate

Leadership and Management Program for Postdocs
U-M Office of Graduate and Postdoctoral StudiesSept 2019
Languages
- enEnglish
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