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Pin Koon E.

Pin Koon E.

Research Assistant

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location of Pin Koon E.Singapore, Singapore

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  • Timeline

  • About me

    Analytical, organic, oligonucleotide chemist

  • Education

    • Nanyang Technological University Singapore

      2012 - 2016
      Bachelor’s Degree Chemistry and Biological Chemistry Second Class (Upper)

      Activities and Societies: Symphonic Band, Junior Common Room Committee (JCRC) of Hall of Residence 5

    • Nanyang Technological University Singapore

      2016 - 2021
      Doctor of Philosophy - PhD Organic Chemistry 4.38

      Awarded the Economic Development Board - Industrial Postgraduate Programme (EDB-IPP) scholarship where I worked with the research and tech dev department of Illumina Singapore

  • Experience

    • Singapore-MIT Alliance for Research & Technology Centre

      May 2015 - Jul 2016
      Research Assistant

      Targeting tRNA methyltransferase for the development of antibacterial drugs

    • Illumina

      Jul 2016 - May 2020
      Research Associate 1

      Working with a team of biologists and chemists, I was involved in the synthesis of modified nucleotides to study the interaction of these modified nucleotides with various DNA polymerases. Through my work, I am proficient in the following: - Nuclear Magnetic Resonance Spectroscopy - High Performance Liquid Chromatography (Reverse Phase, Ion exchange, HILIC)- Fast Performance Liquid Chromatography- Mass Spectrometry- Protein-small molecule conjugation- Small molecule synthesis- Enzymatic assays- Solid phase conjugation of DNA and small moleculesI managed calibration and maintenance services of various equipments such as HPLC, mass spectrometer, freezers and ovens. Show less

    • A*STAR - Agency for Science, Technology and Research

      Jun 2020 - Feb 2021
      Research Fellow

      Develop and synthesize unnatural base pairs, ensuring high quality phosphoramidites and triphosphates were synthesized for ExSELEX.

    • Lerna Biopharma

      Feb 2021 - Jul 2023

      - Planned, design, synthesize and scale up (from nanomole to multi gram scale) various small molecules, nucleosides, delivery ligands, and phosphoramidites- Synthesize oligonucleotides using MerMade 48/192 and Dr Oligo systems- Purification and analysis of oligonucleotides by HPLC using various stationary phases (C8, C18, IEX, SEC)- Design ligand modalities to enable delivery of oligonucleotides to various organs and cell types- Worked in a fast pace, cross disciplinary, start up environment- Set up and maintain chemistry laboratory Show less

      • Scientist II

        Apr 2023 - Jul 2023

      • Scientist I

        Feb 2021 - Apr 2023

    • Amgen

      Oct 2023 - now
      Process Development Scientist

      - Oversaw operations in API process development laboratory- Optimized process for API manufacturing, potentially achieving > $100,000 per year in cost savings - Participated in the feasibility evaluation of new product introduction- Assessed risk in laboratory to ensure safe working environment for the team

  • Licenses & Certifications

  • Honors & Awards

    • Awarded to Pin Koon E.
      Economic Development Board - Industrial Postgraduate Programme (EDB-IPP) Economic Development Board Jul 2016