Benjamin H.

Experience

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  Global TIES, UCSD

  Sept 2012 - Jun 2013

  Student Engineer

  • Provided critically needed fresh water to the Philippines, modified and adapted upon existing ceramic water filtration systems, decreased the water contamination level by 100 fold. • Researched and designed typhoon resistance structure for Gawad Kalinga housing in Philippines, structural analysis using SAP 2000

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  Stein Research

  Jul 2013 - Feb 2014

  Lab Assistant

  • Performed protein analysis, including buffer preparation, protein gel electrophoresis, ELISA, and Western blotting• Assisted with pre-analytical preparation: (e.g., prepare racks, work lists, enter, scan specimens and load automated instruments.)

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  J. Craig Venter Institute

  Sept 2013 - Dec 2013

  Intern

  • Investigated new methods to rapidly and accurately synthesized gene and genomes of any size, such as gibson assembly. • Carried out SOPs involving basic laboratory techniques, calculations, materials measurement, operation of laboratory equipment, and record keeping necessary for patent purpose.

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  Nucelis LLC

  Feb 2014 - Sept 2014

  Researcher

  • Scaled up lab-scale experiments to pilot-scale in order to demonstrate fermentation recovery, purification, and downstream processes.• Designed and optimized the extraction process of squalene and ergosterol from yeast that resulted in the extraction yield of 80% and solvent recovery of 90%.• Produced purified ergosterol and squalene samples for customer evaluation; record and summarization of the extraction process in batch records, log sheets and computer programs• Responsible for routine cleaning and maintenance of processing equipment and analysis of extracted and purified samples of squalene/ergosterol using HPLC, GC, and other techniques. Show less

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  Certis USA

  Oct 2014 - Feb 2016

  Process Engineer

  • Oversaw fermentation recovery, granulation, and packaging processes involved in the production of natural biological pesticides.• Lead a team of 25 operators and was responsible for creating and optimizing standard operational procedures, supervising operation of production processes, monitoring plant safety, and training production personnel.• Developed design of experiments and optimization approaches on fluidized bed granulator that increased manufacturing throughput over 14 product lines.• Identified and implemented changes in the granulation process that reduced downtime and rework rate.• Scaled up the fluidized bed granulator and recipes from pilot plant to manufacturing scale• Analyze/resolve process issues and failures, identify root causes and take corrective action, while implementing long-term solutions• Worked with vendors to acquire new equipment to streamline and facilitate process scale up. Show less

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  Amgen

  Feb 2016 - now

  Senior Engineer

  - Manage and progress 24+ Amgen Oncology portfolio products from early pipeline (FIH) to commercialization.- Conduct Make-A-Batch exercise to identify gaps in the process; once gap is identified work with the teams to develop a solution plan- Evaluate product impact from manufacturing process, equipment, and raw material changes. - Oversee ~90% of Amgen clinical tech transfer- Work directly with clinical manufacturing to support ongoing production, new product introductions, and process optimization- Collaborate in a team environment (Attribute Sciences, Process Development, Project Management, Manufacturing, Regulatory, Compliance, and Quality) to ensure all information is relayed correctly and captured. - Lead the initiative to transform the drug product technology transfer process from paper based to a digital process (PLM).- Established process limits for multiple large molecule manufacturing processes using statistical analysis and process modeling techniques.- Integrated the use of data software, SIMCA and Spotfire, in typical operations to perform real-time analyses and visualizations of data sets from across the manufacturing network.- Perform Continuous Process Verification and Statistical Process Control for commercial drug product manufacturing in support of regulatory commitments. Show less