Elena Santidrián Yebra-Pimentel

Experience

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  Lema & Bandin

  Jul 2012 - Sept 2012

  Intern

  Analysis of clinical samples for diagnosis purposes (microscopy, ELISA, cell culture, etc..)

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  Department of Genetics, University of Santiago de Compostela

  Feb 2013 - Aug 2014

  Research Scientist

  During my time as research scientist I was a member of the Ethical Committee to evaluate animal experiments, supervised and mentored students, participated in educational projects and was actively involved in two main research lines focused on colorectal cancer and toxicology research. I was responsible for the cancel cell line and primary tumors maintenance, the development of zebrafish models for drug screening, and in the execution of in vivo assays, including HTS of small molecules and biodistribution analysis of PNP (polymeric nanoparticles) for drug-delivery purposes, using confocal microscopy, statistical and image analysis. As a result of this research, I authored a scientific publication and presented a poster at an international conference. Show less

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  GENEAQUA S.L.

  Feb 2014 - Apr 2014

  Research Intern

  Genotyping and parentage analysis for optimizing breeding programs for the aquaculture industry

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  ZF-screens B.V.

  Sept 2014 - Mar 2018

  My PhD research centered on the development of advanced genomic resources to enhance breeding strategies for endangered freshwater species. As a doctoral candidate within a SME, I also actively participated in company projects, which primarily focused on RNAseq and comprehensive genomics projects closely aligned with my research. My main responsibilities involved the design and execution of experiments and data analysis using available and in-house developed bioinformatics tools. In the lab, I master techniques such as cell culture, HTS of novel compounds, nucleic acid isolations, elecrophoresis, assay development, cloning, sequencing, image analysis and gene expression analysis (RNAseq, qPCR). Additionally, I was actively involved in the development and production of novel zebrafish disease models using CRISPR-Cas knock-down. Show less - In vivo zebrafish toxicity assays in wild-type, mutant and transgenic lines (high-throughput screening of small molecules and chemical libraries).- Image analysis (Image J, GraphPad, JMP)- Generation of knockout zebrafish lines (CRISPR/Cas9) and mutation genotyping.- Nucleic acid isolation.- Literature review, experimental design and data analysis.- Results reporting and discussion internally and in project meetings- Results dissemination through conferences (oral presentations and posters) and publication of scientific articles. Show less

  • PhD Candidate Scientist

    Apr 2015 - Mar 2018

  • Research Intern

    Sept 2014 - Mar 2015
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  Future Genomics Technologies

  Apr 2018 - Nov 2021

  Scientist & Bioinformatician

  My main responsibilities involved the management of the NGS and bioinformatics projects, the development and expansion of the company pipeline and the adaptation of wet lab and bioinformatic pipelines to align with project-specific goals. These included projects such as genome and transcriptome sequencing, assembly and annotation (bacterial and eukaryotic), comparative genomics, RNAseq and SNP analysis for which we also developed and optimized long-read sequencing analysis pipelines (ONT and PacBio) Show less

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  UniQure

  Dec 2021 - now

  Scientist Capsid Development

  As scientist in the Capsid Development team, I contribute to the development and characterization of novel rAAV capsids and technologies to advance our AAV-based gene therapy platform. I am responsible for innovation projects focused on engineering novel BBB-crossing AAV capsids, and my role includes the capsid design, procurement of resources and CROs, experiment design and planning, setting priorities and timelines, reporting and communicating the study results. From the perspective of a department focused on innovation, I have an helicopter view of the whole AAV capsid development field, including small-scale USP and DSP, QC, in vitro potency assay development, in vivo testing in mice and NHP studies and data analysis, focused on bioinformatics analysis. Additionally, my role involves providing scientific insights for IP filings, writing reports and presenting research findings internally and externally. Show less