
Jason Giurleo
Industrial Intern (Research and Development)

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About me
Associate Director at Regeneron Pharmaceuticals, Inc.
Education

Hackensack High School
1991 - 1995Activities and Societies: National Honor Society

Rutgers, The State University of New Jersey-New Brunswick
2001 - 2008Ph.D. Physical Chemistry* Authored a cover article that identified the amyloid formation pathway of β-lactoglobulin. Classified the intermediate aggregate species by conformation and size with the GRIP analysis of DLS and TRF spectroscopy. * Published GRIP (Globally Regularized Interior Point gradient method), a “model-free” global fitting algorithm for fluorescence and DLS data. Uncovers population distributions not apparent by traditional fitting. * Conceptualized and co-authored a new single… Show more * Authored a cover article that identified the amyloid formation pathway of β-lactoglobulin. Classified the intermediate aggregate species by conformation and size with the GRIP analysis of DLS and TRF spectroscopy. * Published GRIP (Globally Regularized Interior Point gradient method), a “model-free” global fitting algorithm for fluorescence and DLS data. Uncovers population distributions not apparent by traditional fitting. * Conceptualized and co-authored a new single molecule fluorescence photobleaching technique applicable for counting single fluorescent subunits within larger multimolecular biological assemblies.* Assembled and maintained picosecond time-resolved fluorimeter for ensemble and single-molecule experiments. Show less

The College of New Jersey
1995 - 1999B.S. Chemistry (Minor: Physics)Activities and Societies: Phi Kappa Psi * Wrote Visual Basic code that automated HyperChem to perform and organize a large set of systematic torsion angle changes and single-point energy calculations of a cisplatin analog bound to guanosine 5'-monophosphate. * Compared modeling results to in-house 195Pt NMR measurements to further understand the structural effects of the minor groove binding of cisplatin analogs as a way to help predict new efficacious chemotherapeutic drugs.
Experience

International Specialty Products
May 1997 - Sept 1998Industrial Intern (Research and Development)* Developed quantitative HPLC (GPC) assays for the determination of percent solids of new polymer products.* Investigated hydro-gel swelling kinetics for a set of cross-linked polyvinylpyrrolidone/vinyl acetate copolymers as part of background data for a new hair conditioner patent application.

Hoffmann-La Roche
Jun 1999 - Jan 2001Contract Scientist (HPLC Method Development)* Performed standard HPLC (IE, SEC, RP, etc.) analytics in a GLP environment. * Followed SOPs and assisted with method qualification and impurity characterization. * Developed and validated an SOP for a combination IE/SEC tandem purity assay for peginterferon.

Rutgers University
Oct 2008 - Aug 2011Postdoctoral Fellow / Visiting Scholar* Published the kinetic mechanism and protein aggregation free-energy landscape for amyloid fibril formation of ß-lactoglobulin developed from quantitative analysis and simulation of DLS and AFM particle-size distributions. * Co-authored article that quantitatively related the rate of in vitro amyloid formation of α-synuclein (implicated in Parkinson’s Disease) with accessibility to hydrophobic interfaces. Work was praised in a Nat. Chem. editorial.

Regeneron Pharmaceuticals, Inc.
Aug 2011 - nowAssociate DirectorTechnology development of fluorescent and radionuclide imaging reagents in vitro and in vivo applications.Protein Conjugation (large and small-scale antibody drug conjugates, haptens, fluorescent-labeling, radio-labeling)Purification and characterization of protein conjugates. Research support of clinical programs (fluorescence assays).Technology development of reagents and small molecules.
Licenses & Certifications
- View certificate

Leading Inclusive Teams
LinkedInFeb 2021 - View certificate

Skills for Inclusive Conversations
LinkedInFeb 2021
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