
Joseph F. Holson

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About me
President (ret.) of WIL Research Laboratories
Education

East Carolina University
-Master of Arts (M.A.) BiologyMaster's Thesis: Teratogenic Potential of D-Lysergic Acid Diethylamide (delysid) in the Albino Rat.

University of Cincinnati College of Medicine
-Doctor of Philosophy (PhD) PhysiologyDoctoral Dissertation: Relative transport roles of chorioallantic and yolk sac placentae on the 12th and 13th days of gestation.

East Carolina University
-Bachelor of Science (B.S.) Biology
Louisiana State University
-Traineeship in Reproductive Physiology
Experience

National Center for Toxicological Research
Jan 1973 - Jan 1980Responsible for administering the Developmental Toxicology research program, which focused on pharmacokinetics, postnatal functional evaluation, and mechanistic evaluations. The division was responsible for implementing and overseeing the National Toxicology Program's (NTP) research and testing activities. Served as manager of the NTP Reproductive Toxicology program from 1978-1980. The division was directly involved in the FDA and EPA's research and development programs. Served as an expert witness and senior advisor to the FDA and EPA on toxicological programs. Show less Responsible for planning, directing, and evaluating research on the biochemical and physiological causes of birth defects. Directed programs aimed at developing methods to evaluate the teratogenic and toxicologic potentials of chemical compounds in animal systems for estimation of human risk. Had primary responsibility for the organization and distribution of the resources of the division in relation to the importance of projects undertaken, including personnel assignments, space allocation, equipment, and extra-divisional activities. Served as Director of the Teratology and Developmental Toxicology programs in the National Toxicology Programs. Show less
Director, Division of Teratogenesis Research
Jan 1977 - Jan 1980Teratology Program Director and Acting Chief of Teratology Division
Jan 1975 - Jan 1977Senior Research Scientist (Physiology and Teratology)
Jan 1973 - Jan 1975

University of Arkansas School of Medicine
Jan 1974 - Jan 1980Faculty Member, Interdisciplinary Toxicology Training ProgramServed as Assistant Professor of Physiology (1974-1978) and was a member of PhD student committees, the Admissions Committee (1974-1978), and the Policy Council (1974-1979) for the Interdisciplinary Toxicology Training Program. Developed and taught a graduate-level regulatory toxicology course, the first in the country, titled "Toxicology and Government Regulations" (1977-1980). This course was prepared in collaboration with Don Snow.

The University of Arizona
Jan 1980 - Jan 1985Annual Guest Lecturer in ToxicologyToxicology Training Program

Science Applications International Corporation
Mar 1980 - Jun 1985Director, Division of ToxicologyDirected the operations of the research and testing toxicology division. The toxicology division had an active research and development program in reproductive toxicology and conducted a range of toxicological tests for evaluating the health effects of drugs, chemicals, and other agents.

San Diego State University
Jan 1981 - Jan 1985Adjunct Professor of ToxicologyGraduate Program in Public Health, Department of Public Health and Environmental Studies

Biomedical Research Institute of America
Jan 1984 - Jan 1986President
Jan 1985 - Jan 1986Vice President
Jan 1984 - Jan 1985

WIL Research Laboratories
Mar 1987 - Nov 2008Served as chief executive officer of the company, having responsibility for all fiduciary and scientific aspects of the company's operations. In addition to presidential functions, remained scientifically active by selective review of data and reports, advising sponsors regarding toxicologic and product development issues, serving as a consultant to federal agencies, publishing scientific papers, giving presentations to various community and scientific organizations, and lecturing at Ashland University. In special cases and at the sponsor's request, served as a study director. For this purpose, a special reporting structure for the Quality Assurance Unit was adapted. Show less
President and Director
Aug 1988 - Nov 2008Vice President, Director of Developmental and Reproductive Toxicology
Mar 1987 - Aug 1988

Ashland University
Jan 1988 - Jan 2008Adjunct Professor of ToxicologyServed on the university's Science Advisory Board (1990-2008) and the Board of Trustees (1993-1998).

WIL Research Holding Company
Sept 2004 - Feb 2009Board of Directors MemberLed management buyout of WIL Research Laboratories and formation of WIL Research Holding Company (WRH) by Behrman Capital in 2004. After the subsequent buyout in 2007 by American Capital, served as Vice President and Chief Scientific Officer of WRH while continuing to serve as President and Director of WIL Research Laboratories (July 2007 - November 2008). Following retirement from active management duties, served as a full-time Consultant/Advisor to WRH (November 2008 - August 2009).
Licenses & Certifications

Diplomate, American Board of Forensic Examiners (DABFE)
Mar 1997
Honors & Awards
- Awarded to Joseph F. HolsonOutstanding Published Paper Demonstrating an Application of Risk Assessment Society of Toxicology, Risk Assessment Specialty Section 2003 Sweeney LM, Tyler TR, Kirman CR, Corley RA, Reitz RH, Paustenbach DJ, Holson JF, Whorton MD, Thompson KM, Gargas ML. Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulations. Toxicological Sciences 2001; 62: 124-139
- Awarded to Joseph F. HolsonOutstanding Published Paper Demonstrating an Application of Risk Assessment Society of Toxicology, Risk Assessment Specialty Section 2002 Holson JF, DeSesso JM, Jacobson CF, Farr CH. Appropriate use of animal models in the assessment of risk during prenatal development: an illustration using inorganic arsenic. Teratology 2000; 62:51–71
- Awarded to Joseph F. HolsonMember, Search Committee for Director of National Center for Toxicological Research - 1979
- Awarded to Joseph F. HolsonListed in 13th Edition of "American Men and Women of Science" - 1976
- Awarded to Joseph F. HolsonCommendable Service Award US FDA 1974
- Awarded to Joseph F. HolsonPoteat Award North Carolina Academy of Sciences 1969 For research on teratogenicity of LSD
- Awarded to Joseph F. HolsonSigma Xi Senior Research Award East Carolina University 1969
- Awarded to Joseph F. HolsonMember of Board of Directors and Secretary San Diego Biomedical Research Institute 1980-1986
- Awarded to Joseph F. HolsonSecretary, Third International Congress of Toxicology - 1981-1983
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