Bogdan Aurel Sava PhD

Experience

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  The University of Freiburg

  Jul 2011 - Aug 2012

  Postdoctoral Researcher

  The involvement of NGF and acetylcholine in mechanisms of neuronal plasticity was my main subject of interest. Several lines of evidence suggested that acetylcholine (ACh) and the neurotrophins profoundly affect neuronal plasticity in the hippocampus and neocortex. The cholinergic system is crucially involved in learning and in short- and long-term memory. Signaling by BDNF and its receptor trkB has been shown to play important roles in neuronal plasticity, both under physiological and pathophysiological conditions. However, an involvement of the prototypic neurotrophin nerve growth factor (NGF) and its receptors trkA and p75NTR in these functions has not been profoundly investigated. My job was to set up the sharp electrode and field potential recording methods in order to investigate the impact of NGF-signaling on neuronal plasticity in the amygdala and hippocampus at electrophysiological level (LTP, LTD, PPFand persistent activity). Weniger anzeigen

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  The University of Freiburg

  Jan 2012 - Jan 2013

  Research Assistant

  Neurozentrum Freiburg, is one of the biggest University Medical Hospital for brain surgery in Germany, mainly for epilepsy, therefore my main project was focusing on Levetiracetam (LEV), one of the most important anti-epileptic drugs. Although binding studies have shown that LEV interacts with the synaptic vesicle protein 2A (SV2A) the mechanism of action largely remains unknown. Therefore I used hippocampus slices of juvenile rats (P17-P22) and human material, in order to study the electrophysiological effects of LEV on granule cells (GCs) and fast spiking basket cells (BCs) from dentate gyrus (DG), hippocampus. Our results are the first report showing that LEV modulate the synaptic transmission in epileptic tissue. Weniger anzeigen

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  NEUROSERVICE

  Nov 2013 - Jan 2019

  Team and laboratory managementManage and lead an R&D team of 5 technicians and 4 PhDMonitoring and organizing the R&D projectsPlanning and organizing production schedules (successfully achievement of the study milestones, previously agreed with the clients);Scientific reportsValidation of the scientific resultsWriting and validation of the SOP'sAcknowledged for meeting company goals while maintaining excellent client relationsOrganize startup meetings and study site initiation conferenceEstimating, negotiating and agreeing budgets and timescales with clients and managersAttention to details and accuracyDetermining quality control standardsData base managementProject leader Weniger anzeigen

  • Head of the Patch Clamp Department

    Sept 2014 - Jan 2019

  • CRO Research Assistant

    Nov 2013 - Aug 2014