Ganesh Kumar MOTHUKURI

Experience

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  V.S.Lakshmi Degree College for Women

  Jul 2008 - Dec 2009

  Lecturer

  • Conducted theory classes in both organic chemistry and inorganic chemistry to students of age 16-20.• Trained students for inorganic chemistry laboratory experiments.• Mentored students to demonstrate science projects during science festivals.

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  IISER-Pune (Indian Institute of Science Education and Research-Pune)

  Aug 2010 - Mar 2016

  PhD

  • Studied the conformational behavior of naturally occurring vinylogous amino acids in alpha, gamma- hybrid peptide sequences.• Discovered novel supers-secondary structures like miniature β-meander, helix-turn-helix using smaller peptide sequences (7-10 AA length). • Skilled at multi-step organic synthesis of special amino acids like β-, γ- and δ- amino acids. • Established chemical methodologies to synthesize small molecules like pyrazines and γ-lactams.• Expert in analytical techniques like 2D-NMR (ROESY, NOESY, COSY), single crystal XRD, MALDI- TOF/TOF, circular dichroism and ITC. Show less

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  EPFL (École polytechnique fédérale de Lausanne)

  Apr 2016 - Mar 2021

  Scientific Collaborator

  • Developed state-of-art chemical technology to generate macrocycles libraries in solution-phase. Significantly, this method obviated product purification since it showed very good yields for wide range of substrates, which in turn saved a lot of time and money in the early drug discovery process. • Designed, synthesized, and screened of large libraries of peptide-like macrocycles against various therapeutic targets. • Performed hit identification, hit validation and SAR studies. • Developed in vitro screening assays for different protein targets for hit identification.• Published my work in 5 research journals and 1 patent Show less

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  University of Geneva

  Apr 2021 - now

  Research And Teaching Fellow
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  Orion Biotechnology

  Apr 2021 - now

  Senior Scientist