Antos Shakhbazau

Experience

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  Institute of Genetics and Cytology, NASB

  Jan 2006 - Jan 2010

  Research Scientist

  - Created and validated multiple vectors for mammalian/plant/bacterial genetic engineering;- Co-author on patents related to pharmaceutical substance synthesis and gene expression systems: BY 11553, BY 13127, BY 15563;- Organized and supervised a commercial unit for PCR-based GMO detection at the Institute;- Collaboration with RSPC of Transfusion and Medical Biotechnology: Human mesenchymal stem cells (bone marrow/umbilical cord blood) differentiation, neurotrophin gene delivery using dendrimer nanocomplexes;- Developed protocols are currently used at RSPC for experimental cell therapy of epilepsy patients (Clinical trial NCT02497443). Show less

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  University of Calgary

  Jan 2010 - Jan 2015

  Research Scientist

  - Cell therapy and neurotrophin gene therapy for nerve regeneration in animal models;- Stem cell-derived Schwann cells, doxycycline-regulated expression systems;- Biomaterials: microcarrier stem cell culture in bioreactors, 3D matrix testing; - Glia-axonal ribosome microvesicle traffic as part of multiple sclerosis disease modeling;- Secured competitive funding from “Alberta Innovates: Health Solutions” (AIHS), project name: “Improvement of skin-derived precursors to enhance nerve regeneration by lentiviral transduction of neurotrophic factors”.- 2012: Award "Researcher of the Year" (PDF) by the Hotchkiss Brain Institute. Show less

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  University of North Texas

  Jan 2016 - Jan 2018

  Research Associate

  - OSKM reprogramming of patient cells, 3D differentiation of embryonic stem cells and iPSC;- Transcriptomics data analysis and visualization in R;- Modeling stress and disease using CRISPR/Cas9-engineered cerebral organoids;- UPR pathway & gamma radiation: screening for small molecule effects on organoids (including minocycline, rapamycin).

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  EPAM Systems

  Jan 2019 - now

  Senior Software Engineer

  - Data integration and business analysis for international Big Pharma & healthcare providers; - Python/SQL and GenAI-powered solutions for data quality control, lineage tracing, ad-hoc model visualizations, context navigation and instructions-to-code translation;- Clinical trial data analysis;- Data models, data factory pipelines, ETL functional designs and code, metrics, ML;- SQL engineering for MIS, a FHIR-based donor registry for organ and stem cell transplantation (https://solutionshub.epam.com/solution/mis-platform). Show less