Federico Munafò

Experience

• 

  Københavns Universitet - University of Copenhagen

  Oct 2016 - Mar 2017

  Master Thesis Student

  - Spearheaded the design, synthesis, and characterization of potential Keap1 inhibitors, targeting the treatment of ischaemic stroke- Implemented the emerging deconstruction-reconstruction approach to design a fragment library, facilitating the identification of novel lead compounds with high potency and selectivity- Conducted efficient synthesis and purification of sulfonamides, benzo[7]annulene derivatives, and benzotriazole derivatives, employing state-of-the-art organic synthesis techniques- Utilized advanced analytical techniques, including NMR spectroscopy and LC-MS, for the comprehensive characterization of synthesized organic compounds, ensuring their structural integrity and purity- Actively contributed to the interpretation and analysis of research results, employing scientific rigor and critical thinking to guide decision-making processes Show less

• 

  Farmacia degli Oleandri

  May 2017 - Oct 2017

  Student Trainee

  Dispension of prescriptions and patients counselling on drug therapies, warehouse management, storage and dispension of controlled drugs (such as narcotic analgesics), preparation of galenicals.

• 

  Food Contact Center S.r.l.

  Nov 2017 - May 2018

  Analytical Chemist

  - Conducted chemical analysis on food contact materials to ensure compliance with national and international legislation- Proficient in the determination of metals using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES)- Expertise in assessing overall migrations and specific migrations from food contact materials, ensuring safety and quality standards are met- Conducted qualitative and quantitative organic analysis using Gas Chromatography-Mass Spectrometry (GC-MS)- Applied toxicology risk assessment methods to evaluate the potential health risks associated with food contact materials- Conducted off-flavor analysis using Solid-Phase Microextraction (SPME) to assess and identify any undesirable flavors or odors- Facilitated panel tests to evaluate sensory attributes and ensure compliance with sensory requirements and consumer expectations- Maintained meticulous documentation of analytical procedures, results, and data analysis for regulatory compliance and quality assurance purposes Show less

• 

  Istituto Italiano di Tecnologia

  Nov 2018 - Mar 2022

  - Conducted research focused on the design and synthesis of DNA polymerase eta inhibitors as potential anticancer drugs, specifically targeting chemoresistant tumors- Led hit-to-lead optimization efforts, utilizing Structure-Activity Relationship (SAR) analysis to improve compound potency- Expertise in organic multi-step synthesis employing state-of-the-art techniques- Employed analytical techniques, including NMR (1H-NMR, 13C-NMR, COSY, and HSQC) and LC-MS, for product characterization and structural elucidation- Collaborated with a diverse team of scientists and researchers, fostering a multidisciplinary approach to problem-solving and knowledge sharing Show less

  • Fellow

    Nov 2021 - Mar 2022

  • PhD Student in Medicinal Chemistry

    Nov 2018 - Oct 2021
• 

  Axxam

  Apr 2022 - now

  Scientist

  - Serving as the Principal Investigator (PI) for internal and customer projects, leading a team of researchers and driving the project's objectives, milestones, and outcomes- Design and synthesis of new compounds for drug discovery projects- Evaluation and selection of the most promising hit compounds resulting from High Throughput Screening (HTS) campaigns, considering their chemical, biological, and intellectual properties- Contribution to the expansion and enhancement of the compound library for High Throughput Screening (HTS), ensuring its diversity and relevance for drug discovery efforts- Use of data analysis programs to analyze and interpret screening results, identify trends, and prioritize compounds for further investigation Show less