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Mattia Siragusa

Mattia Siragusa

Member of High School Council

Followers of Mattia Siragusa513 followers
location of Mattia SiragusaRoskilde, Region Zealand, Denmark

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  • Timeline

  • About me

    General Manager | I like complex business challenges no one knows where to start. PhD | MBA (Executive Candidate)

  • Education

    • Università degli Studi di Pavia

      2013 - 2014
      Master of Science (M.Sc.) Biomedical Physics

      Thesis title: FRAP and Super-resolution microscopy to investigate GFP-Rev7 mobility after low LET radiation-induced DNA damage.Description:In this thesis, spatial and temporal scale of DNA induction/repair mechanisms were investigated by means of several microscopy techniques, such as Standard Fluorescent Microscopy, Confocal Microscopy, Structured Illumination Microscopy (SIM) and Fluorescence Recovery After Photobleaching (FRAP).In this work I investigated the possible role of… Show more Thesis title: FRAP and Super-resolution microscopy to investigate GFP-Rev7 mobility after low LET radiation-induced DNA damage.Description:In this thesis, spatial and temporal scale of DNA induction/repair mechanisms were investigated by means of several microscopy techniques, such as Standard Fluorescent Microscopy, Confocal Microscopy, Structured Illumination Microscopy (SIM) and Fluorescence Recovery After Photobleaching (FRAP).In this work I investigated the possible role of the protein called Rev7 in the DNA Damage Response, after low LET radiation.Rev7 is believed to repair DNA damage via Pol-zeta, which is made of the Rev3 catalytic subunit plus the Rev7 accessory protein. The mutant Rev7-C70R disrupts Rev7 interaction with Rev3, so that such mutant can be exploited as a tool to observe indirect evidence of Rev7 role in DNA damage repair.Obtained results point to the confirmation of a Rev7 involvement in DNA repair after low LET radiation at late times after the exposure. Show less

    • Danmarks Tekniske Universitet

      2015 - 2017
      Doctor of Philosophy (Ph.D.) Physics/Radiation Biology

      It is the aim of my PhD to refine the inter-comparison of biological damage to given biological systems at equal dose levels applied at different dose rates, radiation energy and with both internal and external sources. The ultimate goal is to use a detailed description of physics for the energy transfer to the living cells to find relevant modifications to standard dosimetry. Most importantly the dose rate dependence of biological damage should be measured and made predictable to point where… Show more It is the aim of my PhD to refine the inter-comparison of biological damage to given biological systems at equal dose levels applied at different dose rates, radiation energy and with both internal and external sources. The ultimate goal is to use a detailed description of physics for the energy transfer to the living cells to find relevant modifications to standard dosimetry. Most importantly the dose rate dependence of biological damage should be measured and made predictable to point where such effect can be corrected for across comparisons of external and internal radiation. This will be of major interest to members in the field of radiation protection and radiotherapy. Finally, it is the hope to quantify the expected, but quantitatively unknown, increase in damage exerted by dose delivered by internal emissions of very low energy electrons and Auger cascades. Show less

    • Università degli Studi di Milano

      2006 - 2012
      Bachelor of Science (B.Sc.) Physics

      Thesis title:Elementary and colorimetric analyses for the determination of pictorial thickness.Description:Physical non-destructive analyses allow secure authentication of original artworks and provide support during restoration works of cultural heritage. X-Ray Fluorescence (XRF) is a well-established non-destructive technique. It allows the identification of chemical elements contained in a sample, revealing the characteristic X-ray fluorescence radiation. However, due to the… Show more Thesis title:Elementary and colorimetric analyses for the determination of pictorial thickness.Description:Physical non-destructive analyses allow secure authentication of original artworks and provide support during restoration works of cultural heritage. X-Ray Fluorescence (XRF) is a well-established non-destructive technique. It allows the identification of chemical elements contained in a sample, revealing the characteristic X-ray fluorescence radiation. However, due to the limitations in detecting elements with atomic number smaller than 15 (Phosphorus), XRF is not the perfect tool in the analysis of pictorial layers.The aim of the thesis is to combine XRF and Vis-NIR spectroscopy to determine the thickness of pictorial layers that are built on the basis of painting techniques of the Italian Renaissance. Beside XRF and Vis-NIR techniques, in this work I suggest the use of the colorimetric parameter "dominant wavelength" to calculate the thickness of pictorial layers. Show less

  • Experience

    • IIS Edith Stein

      Jan 2005 - Jan 2006
      Member of High School Council

    • Grover Cleveland High School

      Jan 2006 - Jan 2006
      Diplomat at the Irmas Youth Media Summit

      Representing the Italian delegation at IYMS, an annual international summit for teen filmmakers. Using digital media and short films to combat violence.

    • AIReC (Association for Information technologies and Civic Networking)

      Jan 2007 - Jan 2008
      Freelance Consultant

      Working on the 'e21-active citizenship' project with the Lombardy Association for Information Technologies and Civic Networking and the University of Milan.Using communication technologies and local networks to stimulate citizen discussion.

    • Pafin 91 srl

      Jan 2007 - Jan 2008
      Freelance Consultant

      Mediating between citizens and local administrations in the Varese district.Working to raise environmental awareness and involve the community in waste management decisions.

    • Il Resto del Michelino

      Jan 2009 - Jan 2012
      Founder and Editor-in-Chief

      Serving as Editor-in-Chief for the local online newspaper 'Il Resto del Michelino.

    • Erasmus MC

      Apr 2014 - Aug 2014
      Conducting research to define the role of the protein Rev7 in DNA damage response

      DNA damage threatens the integrity of our genome. Without repair of these DNA lesions, life would not be possible. Several different DNA repair pathways have developed to counteract different types of DNA lesions. In this project I focused on DNA double strand break (DSB) repair. DSBs can be repaired by two different main DNA repair pathways, called Non-Homologous End-Joining (NHEJ) and Homologous Recombination (HR). HR needs a sister chromatid as a template, while NHEJ does not need any homologous template. They operate with different sets of proteins and under some circumstances they can compete for the same DNA ends. In order to get a better understanding of the molecular mechanisms of these pathways, U2OS cell line with fluorescently tagged Rev7 protein has been generated at the department of Genetics at the Erasmus MC. Accumulation of large numbers of this Green Fluorescent Protein tagged repair protein (GFP-Rev7) was followed in living cells in areas with many DSBs, using various types of microscopes.During my internship, I studied the behavior of the protein Rev7 with and without induction of DNA damage and combined this analysis with mutagenesis of the GFP-tagged proteins in order to identify domains that contribute to the behavior of Rev7.Cell culturing, microscopy, digital image analysis, and modeling of the data were part of the learning experience, which contributed to the development of my Master's thesis. Show less

    • University of Pavia

      Oct 2015 - Apr 2016
      Conducting research to develop a new code for cellular dosimetry calculations

      Project description:Absorbed dose calculations in nuclear medicine are conventionally based on the S-value formalism introduced by MIRD. To extend it to the cellular level and electron emitters, MIRD adopts Cole's stopping power and calculates the Geometric Reduction Factors (GRFs), which provide information on source and target regions. This approach contains some important limitations. In fact, Cole’s formula was obtained just as the derivative of an energy versus range dependence, from electron transmission experiments. GRFs are defined only for simple geometries, while the adoption by the formalism of the Continuous Slowing Down Approximation neglects the finite range of delta rays as well as angular deflections and straggling effects. A new analytical, fast and user-friendly method is needed: called COOLER.The MARLAB-based COOLER program relies on the convolution of two main terms: the first related to the position of electron sources in different cellular compartments, the second to the density of deposited energy in liquid water as a function of radial distance from the source. In our study, we present a method to avoid the limitations coming from the use of GRFs. Instead, we adopt quantities containing information on the spatial distribution of electron emitters, namely the sites of radioactive decays. Moreover, the proposed method replaces the employment of Cole's stopping power by the adoption of energy deposition data derived from Monte Carlo simulations of electron track structure with the code PARTRAC. To make COOLER more ready-to-use, we implemented realistic geometrical models for V79 cells. We proved that our new method handles the geometries correctly and showed that the biggest discrepancies between COOLER and MIRD are generally found around 25 keV, where the disagreement can be higher than 60%. Show less

    • Radiation Research Society (RADRES)

      Dec 2016 - Nov 2018
      SIT Committee member

      Elected member of the SIT Committee of the Radiation Research Society.http://www.radres.org/

    • DTU - Technical University of Denmark

      Sept 2017 - Sept 2017
      Course lecturer: Medical Radiation Dosimetry Course

      Title of the lecture: "The amazing world of low-energy electrons"

    • DTU - Technical University of Denmark

      Nov 2017 - Nov 2017
      Course lecturer: Medical Application of Ionizing Radiation

    • DTU - Technical University of Denmark

      Jan 2018 - now

      Head of Hevesy Laboratory.Driving pharmaceutical business growth through commercial excellence and digital transformation.Radiopharma. Leading Innovation, Safety, and Maintenance in pharmaceutical manufacturing, with a focus on digitalization and process optimization.Radiopharma. Establishing operations team, scaling up the facility, and leading projects.Radiopharma. Leading team, performing maintenance of critical hardware for pharmaceutical production, and digitalizing procedures. Developing Hardware for R&D Developing Software for R&D

      • General Manager @ Hevesy Laboratory

        Nov 2023 - now

      • Operations Manager @ Hevesy Laboratory

        Jun 2022 - Nov 2023

      • Special Consultant

        Dec 2020 - Jun 2022

      • Cyclotron Engineer and Radiation Physicist

        Jul 2019 - Dec 2020

      • Postdoctoral Researcher

        Jun 2018 - Jun 2019

      • Research Assistant

        Jan 2018 - Jun 2018

    • Novo Nordisk

      Jan 2025 - now
      Consultant

      EMBA Consultancy Work

  • Licenses & Certifications

    • NASA Space Radiation Summer School

      NASA - National Aeronautics and Space Administration
      Jun 2017
      View certificate certificate

    • DTU EMBA - Silicon Valley Innovation Leadership

      UC Berkeley Executive Education
      Nov 2023
      View certificate certificate

  • Honors & Awards

    • Awarded to Mattia Siragusa
      Best Master Project 2025 DTU Executive MBA Jun 2025
    • Awarded to Mattia Siragusa
      Young Investigator Award European Radiation Research Society (ERRS) Jul 2017 ERRS and GBS annual meeting, Essen, Germany