Matej Godec

Experience

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  University of Ljubljana, Faculty of Biotechnology

  Jan 2015 - Jul 2015

  BSc thesis

  "CDT cytotoxin of Aggregatibacter actinomycetemcomitans bacteria."Verification of CDT cytotoxin genotoxicity of a periodontal pathogen Aggregatibacter actinomycetemcomtians with the intent of identifying a mutation site with a potential to deactivate the toxins’ activity.

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  Wageningen University & Research

  Apr 2016 - Jul 2016

  Conducted a research project for biopharmaceutical company Synthon for increasing the annual production of monoclonal antibodies up to 300 kg in a fed-batch bioreactor.-Estimation of the project feasibility -Development and implementation of innovative ideas for optimization of the current production process -Designing experiments for testing innovations-Providing an overview of the process scalability -Cost estimation Studying the effects of LPS antagonists on the expression levels of NF-κB, and IL-8 and TNFα production in HEK-Blue and THP-1 cells, respectively.

  • Designing an innovative bioprocess for enhancing the production of monoclonal antibodies

    May 2016 - Jul 2016

  • Exploring the LPS-induced TLR4 activation: a key to antiseptic drug development

    Apr 2016 - May 2016
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  Wageningen Universiteit en Researchcentrum

  Oct 2016 - Jul 2017

  MSc Thesis

  "Development of HyPer-3/SypHer-3 baculovirus transduction system for monitoring mitochondrial ROS and pH transients"Construction and design of mitochondrial targeted hydrogen peroxide sensor (HyPer-3) and pH sensor (SypHer-3). Incorporation into a baculovirus shuttle vector for efficient transduction of mammalian cell lines for measuring ROS levels.

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  Wageningen University & Research

  Oct 2017 - Apr 2018

  MSc minor thesis

  "Generation of mitochondria-targeted HyPer-3 and SypHer-3 recombinant lentiviruses for C2C12 transduction."Development of a recombinant lentivirus transduction system with the intent of measuring hydrogen peroxide levels in mitochondria of C2C12 cells during oxidative stress.

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  University of Ljubljana, Faculty of Pharmacy

  Dec 2018 - Jun 2020

  Researcher

  Establishing pKu70 expression as a biomarker in B-cell samples of chronic lymphocytic leukaemia patients. Analysis of agonist-induced EP4 signaling pathways.

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  Krka

  Jun 2020 - now

  Independent Researcher in Preclinics