Louane Sigrist

Experience

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  Université Clermont Auvergne

  Jan 2016 - Jan 2017

  Tutor

  Tutor in physics, chemistry and algorithmics (C) for first-year students.

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  John van Geest Cancer Research Center (Notthingham Trent University)

  Apr 2017 - Jun 2017

  Bioinformatics scientist intern

  Mission: Bioinformatics analyzes of public data on different types of cancer• Compilation and manipulation of data from different sources• Testing of an updated version of a data-mining methodology using artificial neural networks to identify biomarkers• Suggestion and implementation of the automation of some steps of the methodology• Writing of scripts (Perl, bash) that significantly reduced data processing time• Developement in my free time of a JavaScript interface adapting the hive plot method of network visualization (Krzywinski et al., 2011) to the data of a PhD student, thus allowing him to locate important genes much more easily Show less

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  Informatics for Bio-Companies

  May 2018 - Aug 2018

  Bioinformatics software engineer intern

  Mission: Development of a visualization feature for a multiple alignment software (JAVA)• Familiarization with the source code of the software• Identification of user needs: meeting with a researcher• Development in autonomy of a visualization feature, including interfacing with Pymol• Suggestion and implementation of improvements to the software• Use of Git and GitLab• Production of a commented and documented code

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  CASC4DE

  Nov 2019 - Dec 2019

  Bioinformatics engineer intern

  Mission: Collaboration in the development of an interface for SPIKE, a Python library dedicated to Fourier transform spectroscopies• Apprehension of the problematics and familiarization with the project• Self-training in Flask, a Python framework for web development• Evaluation of different graphics engines• Beginning of the development of a prototype of the interface (HTML/CSS, JavaScript, Python)• Implementation of certain gestures for an interactive display

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  INRAE

  Feb 2020 - Jul 2020

  Bioinformatics scientist intern

  Within the INRAE-Oniris research unit BIOEPAR (Biologie, Epidémiologie et Analyse de Risque en Santé Animale / Biology, Epidemiology and Risk Analysis in Animal Health).Mission: Analysis of the genetic diversity of the Ixodes ricinus tick from transcriptomic sequences• Processing and analysis of RNA-Seq data (including SNP genotyping, functional annotation, statistical analyzes)• Work on a computing cluster under SLURM using various existing bioinformatics tools as well as scripts written as needed (Bash, python, R)• Organization of the work for reproducibility• Regular presentation of my work to my supervisor• Writing of a report in the form of a scientific article• Contribution to a study on tick-associated viruses: Search for iflavirus sequences in several tick transciptomic datasets (Daveu et al., 2021) Show less

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  University of Lorraine

  Dec 2020 - Jun 2021

  Engineer in bioinformatics

  Within the CAPSID team (Computational Algorithms for Protein Structures and Interactions) - Inria, CNRS, University of Lorraine.Mission: Design and implantation of an integrative information system for the study of the structural determinants of transplant rejection• Defined the needs of the different project participants• Designed and developed a database• Populated the database with data from various sources (biomedical data, local structural data, data from public databases)• Worked in autonomy with weekly meetings• Communicated regularly with a multidisciplinary team (phD student in structural biology, members of a transplantation department)• Data mining (Python)• Development of a conceptual model, transition to the relational model, implementation on MySQL server Show less

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  CNRS

  Jun 2021 - Oct 2021

  Engineer in bioinformatics

  Extension of my contract within the CAPSID team (Computational Algorithms for Protein Structures and Interactions) - Inria, CNRS, University of Lorraine.• Continuation of the establishment of an integrative information system for the study of the structural determinants of transplant rejection• Development of an interface for visualizing structural data (JavaScript)• Version management (Git, GitLab), containerization (Docker)

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  Greater Paris University Hospitals - AP-HP

  Apr 2022 - Sept 2022

  Ingénieure hospitalière

  Au sein du laboratoire d’Immunologie et Histocompatibilité à l'Hôpital Saint-Louis.