Brian Roche

Experience

• 

  QTest Labs, Inc

  Jan 2004 - Jan 2007

  Director
• 

  Battelle

  Oct 2007 - Jun 2014

  Research leader with 15 years experience in the field of cardiovascular safety pharmacology. Directed a variety of in vivo studies, both GLP and non-GLP, primarily with cardiovascular, respiratory and CNS parameters as the study endpoints. Technical lead for development of predictive and translatable model systems to investigate drug-induced cardiac injury and late discovery studies along with development of new innovative assays.

  • Research Leader, Safety Pharmacology

    Oct 2013 - Jun 2014

  • Manager, Safety Pharmacology

    Aug 2009 - Sept 2013

  • Principal Research Scientist

    Oct 2007 - Aug 2009
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  WIL Research

  Jul 2014 - Apr 2016

  Director Safety Pharmacology

  Dual Boarded in safety pharmacology and toxicology focusing on toxicological and pharmacological evaluations of compounds for Investigational New Drug (IND) and New Drug Applications (NDA) to the Food and Drug Administration (FDA) and other regulatory bodies for thorough QT studies (E14), phase 0, 1-3 clinical studies, and to select appropriate first-in-human (FIH) doses.

• 

  Charles River Laboratories

  Apr 2016 - now

  Responsible for providing the scientific expertise and leadership on behalf of the Global Safety Pharmacology portfolio at Charles River Laboratories, which includes aligning best practices across sites, developing the Safety Pharmacology strategy, and representing Safety Pharmacology to our clients. Additionally, responsibilities will include oversight of the Safety Pharmacology groups at the Ashland, Ohio; Edinburgh, Scotland; Montreal, Canada; Lyon, France; Reno, Nevada and Spencerville, Ohio sites. This role includes a worldwide focus on the development and implementation of global plans to expand and enhance our exploratory and regulatory Safety Pharmacology services. Show less Responsible for direct technical and administrative aspects of Safety Pharmacology studies. Managing development of Study Directors in the Safety Pharmacology department including recruitment, interviewing, hiring and performance evaluation. Introduction of new technology, study paradigms and system efficiency/quality enhancement. Study implementation and management to include proposal and protocol preparation; study scheduling, planning, and coordinating. Responsible for scientific interpretation of results and reporting of directed studies. Communication with sponsor representatives and consultants. Direct financial, marketing and scientific functions within the discipline of Safety Pharmacology at WIL Research. Supervision of computer system validation and upgrade processes. Show less

  • General Manager

    Jul 2022 - now

  • Executive Director of Global Safety Pharmacology

    Jan 2017 - Jan 2024

  • Director Safety Pharmacology

    Apr 2016 - Jan 2017