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Yixi Chen

Yixi Chen

Research Intern

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location of Yixi ChenUnited Kingdom

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  • Timeline

  • About me

    Postdoctoral staff scientist | CRISPR screen | cloning | transduction | iPSC differentiation | Single cell RNAseq | Bioinformatics

  • Education

    • Zhejiang University

      2012 - 2016
      Bachelor of Science - BS Biomedical Sciences, General

      Relevant courses: Neurosciences, Molecular Cell Biology, Genetics & Developmental Biology, Pharmacology & Drug Development, Probability Theory & Mathematical Statistics, Informatics and Statistics in Biomedical Sciences, C Programming. Overall GPA 3.84/4.00Dissertation: Sexual dimorphic regulation of peripheral sex hormones on stress response- Worked with rat model, delivered chronic unpredictable stress paradigm and acute stress- Mastered rat behavioural tests including open… Show more Relevant courses: Neurosciences, Molecular Cell Biology, Genetics & Developmental Biology, Pharmacology & Drug Development, Probability Theory & Mathematical Statistics, Informatics and Statistics in Biomedical Sciences, C Programming. Overall GPA 3.84/4.00Dissertation: Sexual dimorphic regulation of peripheral sex hormones on stress response- Worked with rat model, delivered chronic unpredictable stress paradigm and acute stress- Mastered rat behavioural tests including open field test, forced swim test, sucrose preference test- Preformed rat gonadectomy Show less

    • The University of Edinburgh

      2015 - 2016
      Master of Science - MS Biomedical Sciences, General

      Activities and Societies: Attended Scottish Accreditation Board (SAB) Animal Training Module 1, 2 and 3 (Small Animals) in Nov 2015 and was certified for personnel working under the Animals (Scientific Procedures) Act 1986, with species mouse and rat. Project: Critical parameters affecting midbrain dopaminergic differentiation of human embryonic stem cells.- Optimized midbrain dopaminergic differentiation of human embryonic stem cells- Mastered assays for differentiation QC including RT-qPCR, ELISA, flow cytometry, immunostaining and fluorescence microscopy

    • The University of Edinburgh

      2016 - 2020
      Doctor of Philosophy - PhD BIOLOGICAL AND BIOMEDICAL SCIENCES

      Activities and Societies: Gave poster and oral presentation at the following meetings: * Scottish Universities Life Sciences Alliance (SULSA) meeting, Edinburgh, UK * Electronic Notebooks Workshop, Edinburgh, UK * 1st and 2nd Symposium of the Dundee Edinburgh Parkinson’s Research Initiative, Edinburgh, UK * Parkinson's UK Research Conference 2018, York, UK * NECTAR conference 2017, Dublin, Ireland * Parkinson's Disease 200: Back to the Future Conference, Edinburgh, UK Project: Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated mutation of the SNCA gene- Mastered CRISPR targeting and cloning- Used a novel cell model to demonstrate Parkinson’s resistance in α-synuclein mutants, suggesting their potential application for cell replacement therapy- Established and optimized standard protocols for live imaging in the lab: calcium imaging for neuronal activity and TMRM imaging for mitochondria morphology-… Show more Project: Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated mutation of the SNCA gene- Mastered CRISPR targeting and cloning- Used a novel cell model to demonstrate Parkinson’s resistance in α-synuclein mutants, suggesting their potential application for cell replacement therapy- Established and optimized standard protocols for live imaging in the lab: calcium imaging for neuronal activity and TMRM imaging for mitochondria morphology- Proficiency in analysing fluorescence microscopy and live imaging data using ImageJ and MATLABBeyond my academic research, I have a keen interest in data science and analytics tools. I attended workshops and completed online courses on Machine Learning, Bioinformatics and Data Visualisation in MATLAB, Python and R.- Granted certificate on Bioinformatics Training (Aug 2019, Centre for Regenerative Medicine, University of Edinburgh) Show less

  • Experience

    • ACEA Biosciences, Inc.

      Aug 2014 - Sept 2014
      Research Intern

      Hands-on experience of drug screening

    • Tsukuba University

      Jul 2017 - Jul 2017
      Summer Research Student

      Investigated mechanism of retroviral gene silencing during iPSC reprogramming.

    • Wellcome Sanger Institute

      Aug 2020 - now

      I work on an OpenTarget Project NeuroImmune: An integrated approach to understand immune responses across neurodegenerative diseases.I'm in charge of the pool CRISPR screen with single cell RNAseq and spatial readouts. Dissecting the genetic architecture of microglial and macrophage function (Open Target project OTAR2065 Neuroinflammation)

      • Staff Scientist

        Jan 2025 - now

      • Postdoctoral Fellow

        Aug 2020 - Dec 2024

  • Licenses & Certifications

  • Honors & Awards

    • Awarded to Yixi Chen
      Highly Commended Poster Award Scottish Universities Life Science Alliance (SULSA) Sep 2019
    • Awarded to Yixi Chen
      Best poster School of Biological Sciences, The University of Edinburgh Oct 2018 Winner of Institute of Stem Cell Research on poster day
    • Awarded to Yixi Chen
      Best scientific presentation Parkinson's Disease 200: Back to the Future Conference Sep 2017
    • Awarded to Yixi Chen
      Runner-up of Women’s Doubles, Badminton All-Round Cup Zhejiang University Nov 2014
    • Awarded to Yixi Chen
      Excellent All-Round Student Zhejiang University Sep 2014 Excelled in both coursework and extracurricular activities
    • Awarded to Yixi Chen
      First-Class Scholarship Zhejiang University Sep 2013 For ranking 2nd out of 20 students in Biomedical Sciences major