Experience

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  Department of pharmacological sciences, stony brook university

  Jul 2005 - May 2009

  Research assistant

  Maintaining mammalian cell lines, immunostaining neuronal sections, genotyping mice

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  The estée lauder companies inc.

  Jan 2008 - May 2008

  Chemistry intern

  Worked with staff scientists to optimise product formulations as well as perform quality control analysis.

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  Stony brook university

  Jul 2009 - Jul 2014

  Phd in molecular and cellular pharmacology

  My doctoral research was studying the specificity of protein tyrosine kinases and their inhibitors using structural, biochemical, and biophysical techniques. My thesis was divided into two sections: characterization of highly specific bi-substrate competitive Src inhibitors from DNA-templated macrocycles and determining the molecular mechanism of discoidin domain receptor 1 (DDR1) promiscuity for binding small molecule kinase inhibitors. For the first portion of my thesis, I crystallized and determined the structure of Src kinase domain in complex with a novel ATP- and peptide- competitive inhibitor. I also biochemically and biophysically characterized novel inhibitors to demonstrate ATP- and peptide-competiveness. To determine the molecular mechanism of discoidin domain receptor 1 (DDR1) promiscuity for binding small molecule kinase inhibitors, I established a baculoviral expression and purification system to express and purify DDR1 to biochemically and biophysically characterized DDR1’s behavior towards a variety of kinase inhibitors. I also co-crystallized the kinase domain of DDR1 in complex with several different inhibitors to better understand how DDR1 accomodates chemically different small molecule inhibitors. Show less

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  Mrc protein phosphorylation and ubiquitylation unit

  Aug 2014 - Aug 2016

  Postdoctoral researcher

  My post-doctoral work was focused on the study on Wnk kinases and how they regulate the cellular response to changes in osmolarity. I utilised CRISPR/Cas9 technology to tag and knockout individual Wnk kinases in cells to generate useful tools that can be used to study the individual role of these conserved kinases in their signalling cascade. I biochemically characterized small molecule Wnk kinase inhibitors and identified potential Wnk interaction partners identified via mass spectrometry. I also helped develop protocol for the MRC-PPU to utilise CRISPR/Cas9 technology across multiple cell lines. Show less

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  Embl-ebi

  Aug 2016 - Nov 2019

  Scientific database curator

  I was a biocurator for the UniProt knowledgebase, Open Targets, and Gene Ontology Annotation (GOA) Project. My work for UniProt mainly focused on curating the latest information on mammalian proteins so that UniProt was kept up to date on the latest findings and publications. For Open Targets, I provided ontology mappings between UniProt and the Experimental Factor Ontology that the Open Target Platform utilises. This platform is geared towards linking clinical and research data for rare diseases so new disease targets can be found. For the GOA project, I curated data using the Gene Ontology and provided assistance to the users of QuickGO, the gene ontology annotation browser, through the use of webinars and hands on training. Show less

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  Novartis

  Dec 2019 - Jun 2023

  My role is to act as a consultant for data sources for custom business solutions, data harmonization and the use of ontologies and taxonomies to annotate biomedical literature and clinical data. In addition to that, I conduct evaluations for data and text mining tools, AI, and machine learning based tools for business use cases across all sectors of Novartis.

  • Information Manager

    Sept 2021 - Jun 2023

  • Information Scientist

    Dec 2019 - Sept 2021
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  Elsevier

  Jun 2023 - now

  Senior knowledge strategy manager