Antonio Dell'Isola, PhD

Experience

• 

  Tortoriello Luigi & C Laboratorio di Analisi Sas

  Oct 2004 - Feb 2005

  Lab Technician

  1. General Clinical Chemistry Tests.2. Biochemical Blood and Urine Analysis.

• 

  University of Naples Federico II

  Oct 2010 - Jul 2011

  Visiting Student

  1. Organic synthesis procedures for preparation of enantiopure molecules of broad biological and pharmacological interest.2. Supervising undergraduated student projects.3. Partecipate in general lab maintenance tasks.

• 

  University of Reading

  Oct 2013 - Dec 2015

  1. Pharmaceutical Chemistry ( fisrt year practical course) – Dr John Alan Brazier2. The Uses of Metals in Medicine – Dr Katja Strohfeldt-Venables3. Medicinal Chemistry for Pharmacists (Drug targets) – Dr A. J. André Cobb4. Computer practical – Dr A. J. André Cobb

  • PhD Student in Organic Chemistry

    Jan 2012 - Dec 2015

  • Demonstrating Teaching in Lab Classroom

    Oct 2013 - Jan 2014
• 

  Syngenta

  Oct 2014 - Jan 2015

  CASE Internship
• 

  Dextra Laboratories Ltd

  May 2015 - Aug 2017

  Senior Chemist

  Responsible for multistep synthesis of mono- and oligosaccharides, blood group products and other structurally advanced molecules on milligram to kilogram scale. Synthesis planning and assessments, process development work, creation of operation sheets and progress reports.

• 

  Almac Group

  Oct 2017 - Oct 2021

  • cGMP and non-GMP (TSE/BSE free) manufacture of carbon-14 radiolabelled and/or stable labelled active pharmaceutical ingredients (API) and advanced intermediates (e.g. macrocyclic drugs, peptides, bioconjugates). • Creation of Process Description and Manufacturing Direction for cGMP manufacture.• Creation of project updates and campaign reports.• Leading customer calls.• Support Management Team in quotation writing. Responsible for high quality synthesis of carbon-14 radiolabelled active pharmaceutical ingredients (API) and advanced intermediates, in a regulated (cGMP) environment.

  • Senior Isotope Chemist

    Jan 2020 - Oct 2021

  • Isotope Chemist

    Oct 2017 - Jan 2020
• 

  Advanced Accelerator Applications

  Nov 2021 - Oct 2024

  Technical R&D Scientist

  • Design and deliver technical development of formulation of radiopharmaceuticals labelled with innovative isotopes.• Develop and validate analytical methods in accordance with ICH guidelines and with specific reference to quality control of radiopharmaceutical products.• Actively support the transfer of analytical or manufacturing procedures to production sites, external CMOs• Contribute to the preparation of all relevant documents for regulatory submissions.• Contribute to evaluation of new scientific technologies and equipment.• Work with appropriate internal and external partners (e.g. CRO) to address critical drug product needs such as drug product manufacturing and analytical testing.• Actively interact with other CMC team members for the achievement of project’s goals. Show less

• 

  Novartis

  Sept 2023 - now

  Line function: RLT TRD Formulation Project LeaderResponsibilities:- Create and drive with scientific & technological excellence the formulation development of drug products for Radioligand Therapy. Major activities are: - Lead the development of formulations and manufacturing processes of Drug Products.- Lead the development and the qualification of analytical methods together with the AS&T team leader in accordance with ICHs guidelines.- Participate to the transfer of analytical and manufacturing procedures to the relevant department (e.g. Technical Operations, CDMO, etc.).- Draft the CMC documents required to enable regulatory submissions (IND/IMPD, Module3/NDA). Show less Line function: RLT TRD Formulation Project LeaderResponsibilities:- Create and drive with scientific & technological excellence the formulation development of drug products for Radioligand Therapy. Major activities are: - Lead the development of formulations and manufacturing processes of Drug Products.- Lead the development and the qualification of analytical methods together with the AS&T team leader in accordance with ICHs guidelines.- Participate to the transfer of analytical and manufacturing procedures to the relevant department (e.g. Technical Operations, CDMO, etc.).- Draft the CMC documents required to enable regulatory submissions (IND/IMPD, Module3/NDA). Show less

  • Senior Expert Science & Technology

    Oct 2024 - now

  • Expert Science & Technology

    Sept 2023 - Oct 2024