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Jyoti Kashyap, Ph.D.

Jyoti Kashyap, Ph.D.

Biocon

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  • Timeline

  • About me

    Gastric cancer scientist | Ph.D. in Microbiology | Unraveling redox warfare strategies of Helicobacter pylori in gastric cancer incidence and developing novel small molecule inhibitors

  • Education

    • Delhi Public School - India

      -

    • Miami University

      2016 - 2022
      Doctor of Philosophy (Ph.D.) Microbiology

      My PhD hypothesis is that gut microbes are capable of demethylating choline via anaerobicrespiration. Gut microbiome metabolism can have profound effects on human health. Choline, a quaternary amine (QA) highly abundant in our diet, is cleaved by a glycyl radical enzyme,choline trimethylamine lyase (CutC), and its SAM-dependent radical activator, CutD. CutCcleaves choline to form trimethylamine (TMA) and acetaldehyde. TMA in the gut is oxidizedto TMAO by FMO3 in the liver, which… Show more My PhD hypothesis is that gut microbes are capable of demethylating choline via anaerobicrespiration. Gut microbiome metabolism can have profound effects on human health. Choline, a quaternary amine (QA) highly abundant in our diet, is cleaved by a glycyl radical enzyme,choline trimethylamine lyase (CutC), and its SAM-dependent radical activator, CutD. CutCcleaves choline to form trimethylamine (TMA) and acetaldehyde. TMA in the gut is oxidizedto TMAO by FMO3 in the liver, which plays a role in causing atherosclerosis. We have isolated, from a human fecal sample, a bacterial strain capable of anaerobically utilizing choline as its sole carbon and energy source. Show less

    • Birla Institute of Technology and Science, Pilani

      2014 - 2016
      Master's Degree M.E. Biotechnology

      Elucidating the functional aspect of Na + /H + antiporters involved in the alkaline tolerance mechanism in Arthrospira platensis NIES 39Objectives:In-silico analysis of functional elements to understand underlying mechanism of high alkali tolerance ofA. platensis. Genome-wide analysis of alkalophiles and neutrophiles to identify probable functional elementsresponsible for alkaline homeostasis.

    • Dr. D. Y. Patil Vidyapeeth

      2009 - 2013
      Bachelor of Technology (B.Tech.) Bioinformatics

  • Experience

    • Biocon

      Jan 2013 - May 2013
      Biocon

      Research & Development ExperienceSuccessfully identified impurities in Insugen N (an Insulin analog) using HPLC and MS techniquesGained experience in the field by working with a diverse group of interns, scientists, and senior scientists thereby expanding my knowledge and finishing my undergraduate research thesis

    • VLife Sciences Technologies PVt. Ltd.

      Oct 2013 - Apr 2014
      BCIL( Biotech consortium India Limited) Research assistant

      Research & Development Experience We used the tools of computational chemistry to identify structural features which render the molecules Endocrine disruptors in cosmetic prodcuts.

    • Dow

      May 2015 - Jul 2015
      Dow Chemicals India

      Project Development experience • Collaborated with leading R & D Scientists in the industry, identified microbial contaminations in Bio-fertilizer BP-100, and delivered the results successfully to clients.• Maintained scientific records compliant with the industry regulations as evidenced by production of clear, accurate documentation and presentation of the project.• Ensured the equipment and laboratory maintenance under minimal supervision thereby demonstrating independence and establishing credibility. Show less

    • Miami University

      Aug 2016 - May 2022
      Graduate Research And Teaching Assistant

      Research & Development, Project Management and Scientific writing experience• Growth-oriented scientific researcher with experience in isolating and characterizing biochemical pathways in novel gut microbes that can lead to the development of probiotic medical therapies for the treatment of cardiovascular diseases in humans.• Collaborated cross-functionally with peers to gain deep insights into cardiovascular health resulting in the discovery of a potential probiotic as demonstrated by grants written to obtain a total of 3000$ in funding from Miami University, USA.• Strong scientific writing expertise relevant to the characterization of biochemical pathways in human gut environment, as evidenced by the submission of a first-author manuscript,1 publication, 10 conference presentations, and 3 grants. Show less

    • Fred Hutch

      Jul 2022 - Jan 2023
      Postdoctoral Researcher

    • Washington State University

      Mar 2023 - now
      Postdoctoral Researcher

      Postdoctoral Fellow in Dr. Arden Baylink’s Laboratory

  • Licenses & Certifications

    • Doctor of Philosphy

      Miami University
      Aug 2022
      View certificate certificate

    • Introduction to Cultural Competency and Humility

      University of Wisconsin-Madison
      Jun 2022

  • Honors & Awards

    • Awarded to Jyoti Kashyap, Ph.D.
      Ohio Branch ASM Award Ohio Branch American Society of Microbiology Apr 2021 Best poster award for research excellence
    • Awarded to Jyoti Kashyap, Ph.D.
      3 Minute Thesis -Third Place Miami University Mar 2018 Presenting thesis in 3 minutes to public
    • Awarded to Jyoti Kashyap, Ph.D.
      Dr. Susan Rockwood Award Miami University, Department of Microbiology Mar 2018 Award granted for showing research progress as a woman in STEM