Qier WU

Experience

• 

  AP-HP, Assistance Publique - Hôpitaux de Paris

  Apr 2017 - Jun 2017

  Pharmacometrics Intern

  Hopital CochinLaboratory clinical pharmacologySubject: Study of the external validation of pharmacokinetic model of population of valproic acid in pediatricsMission: Seeking the best population PK model for pediatrics used during therapeutic (Nonmen,R)

• 

  Merck KGaA, Darmstadt, Germany

  Apr 2018 - Sept 2018

  Pharmacometrics intern

  Translational Quantitative PharmacologySubject : A retrospective evaluation of Allometry, Population PK and PBPK for Pediatric Dosing using Clearance as a SurrogateMission : -Use a diverse set of compounds to evaluate the prospective application of PBPK models to provide dosing recommendations for pediatric clinical trials using CL as a surrogate for dose.-Build PBPK models for the selected compounds using a standardized work-flow to reduce potential modeler bias. (Simcyp)-Compare PBPK performance along-side other commonly used methods such as traditional allometry and population PK.-Understand any potential impact of different elimination pathways on predictive performance of PBPK models vs allometry and population PK. Show less

• 

  Inserm

  Nov 2018 - Dec 2021

  PhD in bioinformatics&systems toxicology

  INSERM UMRS 1124-T3SEnvironmental Toxicity, Therapeutic Targets, Cellular Signaling & BiomarkersPhd thesis: Developing integrative and predictive bioinformatics models to understandbetter adverse outcome pathway.Mission:-Developing network-based systems pharmacology approaches in elucidating additional unknown mechanisms of toxicity for chemicals. (R,python, cytoscape,SQL)-Cooperating with other groups-Supervising Master students

• 

  Certara

  Feb 2022 - now

  • Active involvement in research and development of mechanistic ADME models implemented within the Simcyp Simulator including collating, reviewing and analysing population, physiological, biological, drug and clinical data for developing various PBPK/PD. • Active involvement in the design, implementation, testing and performance verification of the Simcyp models particularly those related to further development of compound and population databased. • Contributing to consultancy projects when required. • Applying the experience/expertise in assisting with further development and enhancement of drug metabolism, transport and drug-drug interaction modules. • Flexibility to work on projects in areas outside of the previous experience e.g. oral absorption when required. • Training up to act as a tutor for Simcyp workshops when and if needed. • Take on a substantial role in testing the Simulators before and after the release. • Disseminating the outcome of research as poster/podium presentation and publications. • Dealing with client queries and take part in clients’ site visits and on site education. • Assisting with the research and development of externally funded projects e.g. grants. • Maintaining an active interest and awareness of new researches and technologies relevant to the field, expanding the field expertise, and disseminating these within the team . Show less

  • PBPK Research Scientist

    Feb 2023 - now

  • PBPK Research Associate

    Feb 2022 - Mar 2023