Adam Boretsky, PhD

Experience

• 

  The University of Texas Medical Branch

  Oct 2005 - Jul 2014

  Completed Ph.D. dissertation entitled: “Image-Based Biomarkers in the Retina: Applications in Age-Related Macular Degeneration (AMD).”Authored 8 peer-reviewed publications, 5 conference proceedings papers, over 15 poster presentations and contributed to multiple successful grant proposals (including the role of P.I.).Developed image acquisition protocols and novel processing algorithms to compensate for patient motion and identified clinically relevant quantitative metrics to assess ocular health.Streamlined data acquisition and analysis of endogenous biomarkers using an investigational Adaptive Optics Confocal Scanning Laser Ophthalmoscope (AO-cSLO) and 3-D Spectral Domain Optical Coherence Tomography (SD-OCT).Hands-on experience with numerous models of retinal injury and disease (rodent, rabbit, and NHP): Light-induced retinal degeneration, CNV, low dose photocoagulation, oxygen-induced retinopathy, diabetic retinopathy (type I & II), ischemia/reperfusion, and chronic neuroinflammation/degeneration.Provided project consultation and training in biomedical optics and imaging for graduate students, medical students, research staff, faculty, residents, and clinicians.Identified novel applications of in vivo fluorescence imaging in the detection of retinal injury in an aged brown Norway rat model as part of a collaborative effort with the Air Force Research Laboratory.Interpreted clinical imaging data across multiple clinical imaging platforms as a research fellow in the GLAucoma Diagnostic Imaging UTMB Study (GLADIUS).Coordinated pre-clinical experimental design and imaging with university start-up company Transocular, Inc. to investigate a patented non-invasive drug delivery system for the eye in a rabbit model of angiogenesis.Performed proof of concept experimental design and imaging with Base Pair Biotechnologies, to investigate a fluorescently labeled DNA aptamer for in vivo molecular targeting and imaging. Show less Managed clinical research on transdermal delivery of glycerol to improve the efficacy of laser therapy in collaboration with the UTMB Department of Dermatology and BioTex, Inc. Responsibilities included obtaining IRB approval, patient recruitment, informed consent, experimental design, laser safety training, data collection, and quantitative data analysis.Performed pre-clinical investigations with implantable biosensors in rodent models with strict adherence to IACUC protocols to evaluate long term biocompatibility, stability and product performance of UHMW-PE sensors in vivo for up to 1 year.Developed and tested implantable biosensors to non-invasively monitor blood glucose in collaboration with research partners at BioTex, Inc. Longitudinal validation of sensor stability and reliability of glucose measurements with optical coherence tomography were performed in vitro. Show less

  • Ph.D. Candidate

    Aug 2008 - Jul 2014

  • Biomedical/ Clinical Engineering Specialist

    Oct 2005 - Aug 2008
• 

  Air Force Research Laboratory

  May 2012 - Aug 2012

  Repperger Research Intern

  Developed in vitro models of complex vascular networks to simulate dynamics of retinal blood flow.Applied Scanning Laser Doppler Flowmetry to quantitate retinal blood flow in vivo in NHP subjects.

• 

  FDA

  Jul 2014 - Jun 2015

  Postdoctoral Research Fellow

  • Developed and applied multiphoton microscopy (MPM) and optical coherence tomography (OCT) imaging techniques to investigate acute and chronic effects of implanted brain-computer-interface devices on neuronal networks and vascular networks. • Co-authored a research grant funded by the FDA Office of the Chief Scientist entitled: CLARITY – Structural and Molecular Imaging of Whole Organs as an Assay for Injury and Toxicology • Received extensive training in regulatory science research and participated in workshops with government, academic and medical device industry leaders designed to establish regulatory roadmaps for emerging neuroprosthetic devices (i.e brain-computer-interfaces) and diagnostic imaging tools. Show less

• 

  SAIC

  May 2015 - Jul 2019

  Research Biomedical Engineer; Task Order Lead

  • Directed the multi-million dollar annual budget for the Novel Laser Bioeffects Task Order encompassing 25+ project lines supporting strategic Air Force Research Laboratory missions in both basic science and applied research. Duties included designing and evaluating research studies, technical reporting/presentations, procuring advanced instrumentation, and facilitating collaborative research with external government agencies, academic institutions, industry partners, and international research organizations. • Managed multiple teams in the development of machine learning tools to assist in the diagnosis of retinal injury. Convolutional neural networks (CNNs) were trained using imaging data from commercial and prototype imaging systems spanning over 20 years of Air Force sponsored research. • Designed and developed novel in vitro and in vivo models of ultrafast laser tissue interaction to support domestic and international non-ionizing radiation safety standards (ANSI Z136.1, ICNIRP). • Developed multiple python-based image processing techniques for 3D Optical Coherence Tomography data to register, segment, and quantify characteristics of tissue damage and wound healing dynamics in skin and ocular tissue.• Collaborated with academic partners at the University of Texas Medical Branch and Duke University to identify molecular biomarkers of ocular laser injury for a project supported by the Office of the Air Force Surgeon General. Show less

• 

  Revvity

  Jul 2019 - now

  • Senior Field Applications Scientist

    Jul 2019 - now

  • Senior Field Application Scientist

    Jul 2019 - now

  • Senior Field Application Scientist| Automated Cell Count & Image Cytometry

    Jul 2019 - now

  • Senior Field Application Scientist | Automated Cell Counting & Image Cytometry

    Jul 2019 - now