Victor Flores

Experience

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  Centro de Investigación y de Estudios Avanzados del IPN

  Sept 2012 - Sept 2019

  As a Doctoral Research Scientist, I focused on advanced microscopy, immunochemistry, biochemistry, and computational analysis to investigate cardiovascular function. I utilized fluorescence-based techniques, including confocal microscopy and immunocytochemistry, to study the molecular mechanisms underlying cardiac calcium homeostasis disturbances leading to arrhythmias. My role involved developing MATLAB algorithms for analyzing cardiac cell images, improving the accuracy and efficiency of data analysis. I employed immunocytochemistry techniques to detect protein nitrosylation and performed biochemistry experiments, such as western blotting, to analyze protein expression and phosphorylation. Additionally, I mentored and trained master's students in experimental design and data analysis, fostering a collaborative research environment. Show less My research centered on vascular ex vivo pharmacology and computational modeling. I conducted dose-response experiments in rat aorta, developing mathematical models to quantify the contributions of distinct vascular beta-adrenergic receptor isoforms. My work involved creating MATLAB algorithms to simulate receptor binding dynamics and analyze pharmacological data. I collaborated with a multidisciplinary team to design experiments and interpret results, enhancing our understanding of vascular receptor pharmacology. This experience led to the development of novel computational models and experimental approaches that advanced our research capabilities and provided valuable insights into vascular beta-adrenergic receptor signaling. Show less

  • Doctoral Research Scientist

    Sept 2014 - Sept 2019

  • Master Research Scientist

    Sept 2012 - Aug 2014
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  Icahn School of Medicine at Mount Sinai

  Apr 2014 - Aug 2014

  Research Internship-Department of Pharmacology and Systems Therapeutics

  As a Research Intern at the Icahn School of Medicine at Mount Sinai, I was engaged on advanced microscopy and computational analysis to study cardiac function. I supported Ph.D. students in isolating rat cardiac myocytes and imaging calcium transients using laser scanning confocal microscopy. My work involved developing MATLAB algorithms to simulate cardiac calcium sparks, demonstrating the role of the Na-Ca exchanger in heart disease. This experience provided me with valuable insights into the molecular mechanisms of heart disease. Show less

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  University of Wisconsin-Madison

  Aug 2018 - May 2019

  Doctoral Fulbright Research Scientist -Cardiovascular Research Center

  As a Fulbright scientist at the University of Wisconsin, Madison, I specialized in advanced microscopy, biochemistry, and computational analysis to explore cardiac function. I conducted surface electrocardiogram recordings and calcium transient measurements using confocal microscopy to investigate the role of sorcin in catecholaminergic polymorphic ventricular tachycardia (CPVT). I also performed biochemistry techniques, including western blotting, to examine protein expression and phosphorylation and conducted kinetic radioligand binding assays to compare kinetic parameters of cardiac ryanodine receptors. Additionally, I developed MATLAB algorithms for data analysis, enhancing the efficiency and precision of experimental results. Show less

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  University of California, Davis

  Oct 2019 - Feb 2024

  Postdoctoral Research Scientist-Department of Pharmacology

  • Led a research group at the Department of Pharmacology at UC Davis, focusing on identifying and characterizing novel clinical biomarkers for metabolic diseases such as hypertension and diabetes.• Developed and validated three distinct in vitro diagnostic (IVD) immunoassays utilizing Proximity Ligation Assay (PLA) and super-resolution microscopy.• Performed comprehensive analytical validation of immunoassays, assessing sensitivity, specificity, accuracy, measurement range, and reproducibility to ensure robust assay performance.• Conducted clinical validation through prospective studies, including preclinical trials with animal models and clinical performance evaluations with human samples, ensuring compliance with regulatory standards.• Managed and trained a team of researchers and laboratory technicians, resulting in multiple high-profile publications and presentations at four national and international conferences.• Oversaw all aspects of preclinical and clinical trials, ensuring compliance with GLP, GCP, and Institutional Review Board (IRB) regulations. Familiarity of ISO standards including ISO 20916, ISO 14155, and ISO 13485.• Knowledge of the FDA 510(k) submission process for in vitro diagnostics (IVDs), contributing to regulatory strategies for product approval.• Implemented risk management and safety monitoring strategies, maintaining data integrity and addressing potential issues throughout clinical trials.• Collected, analyzed, and interpreted clinical data using MATLAB and R; performed statistical analysis and integrated advanced image processing techniques.• Authored Standard Operating Procedures (SOPs) detailing clinical trial execution and management processes.• Communicated clinical trial results to internal teams, regulatory bodies, and external partners through reports, meetings, and scientific conferences, ensuring transparency and alignment among all stakeholders. Show less

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  Abbott

  Jan 2025 - now

  Sr. Clinical Research Scientist