Sofía Cabezudo

Experience

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  CNIC - Spanish National Center for Cardiovascular Research / Centro Nac. Investigaciones Cardiovasc.

  Jun 2010 - Jul 2011

  Research Assistant

  Undergraduate Collaboration Fellowship from Spanish Government MINECO

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  Instituto de Salud Carlos III

  Sept 2011 - Jun 2012

  Research Assistant

  Research collaboration Fellowship from UAMCategory B Accreditation: Animal Experimentation (UAM-CAM)

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  Centro de Biología Molecular Severo Ochoa, CBMSO

  Jul 2012 - Jun 2019

  Analyze the physiological implications of the Galphaq-mTORC1 axis in the modulation of the process of autophagy, consolidating a new research line in the laboratory based on the results obtained during the stay in Dr. Cuervo’s Lab (NY). Design & perform experiments in cells and mouse models. Implement the ex vivo liver explant protocol to study autophagy in different nutrient contexts upon treatment with different drugs and inhibitors. Writing scientific articles and competitive grant proposals. Key Achievements:• Co-direction of a Final Year Project of a BSc Student. 2018.• Consolidation of the Dr. Cuervo Collaboration• 1 Scientific Publications in High Impact Factor Journals.• Setting-up the protocols to study autophagy ex vivo Show less "Galphaq is a novel modulator of autophagy". Supervisors: Prof. Federico Mayor Menéndez & Dr. Catalina Ribas Núñez.Study the importance of cell survival on nutrient-driven adaptive signaling pathways. Achievements:• Discover the Gaq-mTORC1 axis for autophagy modulation• PhD certificate: Doctor in Molecular Biosciences, Cum Laude.• 6 Scientific Publications in High Impact Factor Journals.• Science communication in National&International Conferences with highly specialized experts in the metabolic and GPCRs fields. Selected for Oral communication in 4.• Consolidation of a collaboration with the worldwide reference autophagy lab of Dr.Cuervo (NY, USA)• Teaching at Biochemistry BSc and Biophysics MSc (UAM). (2014-2017)Main responsibilities:- Design and perform cellular and molecular biology experiments in primary and transformed celllines, and transgenic mouse models.- Preparation of study protocols. - Writing of scientific articles, reviews and competitive fellowships. - Data analysis & interpretation, organization.- Establishment of an international collaboration network.- Mentorship of BSc and MSc Students.Techniques:- Cell culture: cell treatment, transfection, infection and generation of stable cell lines.- Cellular assays: signaling timecourse, proliferation, migration & invasion assays. Subcellular fractionation.- Animal models: Transgenic mice colony management and characterization. Ex vivo explants from different tissues.- Autophagosome - autolysosome vesicles isolation from mitochondrial/lysosomal fraction of rat livers using a metrizamide density gradient centrifugation protocol.- Protein detection methods: cell and tissue Western-Blot, Immunofluorescence & Immunohistochemistry.- Biochemistry: Immunoprecipitation (IP), Co-Immunoprecipitation (Co-IP), Pull-down assay, in vitro phosphorylation.- Flow cytometry assays: Viability, autophagic flux, cell-sorting. Show less

  • Postdoctoral Research Scientist

    Jul 2018 - Jun 2019

  • PhD Research Scientist

    Jul 2012 - Jul 2018
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  Albert Einstein College of Medicine

  Apr 2017 - Jul 2017

  Visiting Research Scientist

  “Study of the implication of Galphaq in Chaperone-mediated autophagy (CMA)”Supervisor: Dr. Ana María Cuervo (New York, USA)Achivements:• Lead a collaboration with the worldwide reference autophagy lab of Dr. Cuervo (NY, USA).• Set-up innovative protocols to study autophagy ex vivo• Visiting Researcher at Albert Einstein College of Medicine. NY (USA). April-July 2017• 1 Scientific Publications in High Impact Factor Journal

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  Spanish National Cancer Research Centre (CNIO)

  Jun 2019 - May 2023

  Postdoctoral Research Scientist

  Establish, manage & drive the cellular and molecular biology line of research within a cutting edge Structural Biology laboratory, to bridge the translation to cancer context of the structural characterization of macromolecular protein complexes by understanding their cellular functions, allowing the design of novel structure-based drugs. Main responsibilities:• Design, plan, optimize, execute & analyze cellular and molecular experiments.• Impact-oriented management of the research line. • Writing of articles and competitive grant proposals. • Establish internal collaborations and networking with experts. • Science communication to specialized small and large audiences in national and international scientific conferences. Science dissemination to Bachelor students, cancer patients, donors and general public to increase citizens awareness of cancer research. Key Achievements:• Set up and lead a new cellular and molecular biology research line• Established 5 scientific collaborations with Principal Investigators and Staff Scientists at CNIO• Co-develop several scientific grant proposals in collaboration with the lab’s PI• Awarded with a competitive Fellowship from Amigos del CNIO Philanthropic Initiative • 2 Scientific Publications in High Impact Factor Journals, one of them as a result of a Covid-19 research project collaboration established during lockdown• Organize and chair the Structural Biology Department seminars and Ad Hoc conferences Show less

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  Fundación Científica de la Asociación Española Contra el Cáncer

  May 2023 - now

  Main responsibilities:• Identification of the needs of cancer patients in the different territories through the AECC provincial headquarters.• Design, plan, optimize & execute the new AECC grant model for the creation of Charts focused on improvement of oncologic patient care.• Design the grant proposal application: Terms and conditions of the call, templates, cost guidance, compatibilities, evaluation guidance.• Design and coordinate the evaluation process of applications: Contact with international experts in humanization-related disciplines (psico-oncology, physiotherapy, grief management, cronic and pediatric care) to create the Expert Evaluation Panel. Contact with patients of the Patient Advocacy AECC program to create the Patient Evaluation Panel.• Dissemination of the call for proposals to different audiences: Researchers, AECC personnel, Patients. • Analysis of gender related data across all AECC fellowships and grants across a 5 year period.• Identification of the main gaps in terms of gender differences in grants awarded, career stabilization, researchers age, calls terms and conditions.• Scientific projects general management: Terms and conditions revision, improvements identification, scientific deliverables revision, evaluation committees organization.• Scientific projects follow up in telematic and on-site meetings to evaluate the scientific advances of the different projects and identify researchers needs to be solved by the Scientific Foundation.Key Achievements:• Set up and lead a new call for the AECC Chart development in collaboration with spanish universities• Established 10 charts AECC-University supported by 10 different provincial headquarters• Develop a gender differences analysis across the AECC calls• Design and set up of different measures to decrease the gender gap in scientific projects allocation and accelerate the stabilization of women in their oncological research career. Show less

  • Senior Innovation Project Manager

    May 2024 - now

  • Senior Scientific Project Manager

    May 2023 - Apr 2024