Dave Oelschlager

Experience

• 

  Biosite

  Jul 1996 - Mar 2007

  • Senior Research Scientist

    Apr 2004 - Mar 2007

  • Research Scientist

    Apr 2001 - Mar 2004

  • Research Associate III

    Apr 1998 - Mar 2001

  • Research Associate II

    Jul 1996 - Mar 1998
• 

  Biosite (Inverness Medical, Alere)

  Apr 2007 - May 2009

  Principal Scientist

  • Explored the development and scaling of a fermentation process using recombinant E. coli cells to increase the production of antibodies from 1mL to over 100L, resulting in a 10X boost in yield.• Headed all aspects of process troubleshooting, experiment optimization, medium design, and final analysis.• Coordinated and led the transition of the fermentation process technology to the manufacturing group.• Aligned objectives and bridged communications with colleagues to design and develop a new fermentation lab, including designing a mammalian cell culture and purification experience and overseeing autoclave, microfluidizer, and other fermentation and laboratory equipment.• Employed in-depth knowledge of gels, westerns, and assay development; performed assays via TECAN and Luminex.• Tasked with independently setting up TECAN and Luminex instruments as well as writing TECAN methods.• Championed the development, enhancement, and integration of innovative assay methods using Luminex beads for high throughput screening of antibodies, data analysis, and sandwich assay development.• Enabled the screening of 96x96 monoclonal antibody matrix for sandwich immunoassay pairs by developing immunoassays using Luminex; guided project assay development and designed final assays for research projects.• Oversaw the scale-down of the antibody production process to enable high throughput screening of antibodies.• Organized and facilitated group meetings to discuss the progress of scientific initiatives.• Collaborated with the product development transfer team and other stakeholders regarding antibody deliverables.• Contributed to the success of key initiatives by serving as a member of core CVD and Cancer programs. Show less

• 

  Astute Medical

  May 2009 - Apr 2018

  Principal Scientist
• 

  BioMérieux

  Apr 2018 - Oct 2023

  • Advance the development of the new NephroClear™ assay in close collaboration with project team members.• Maintain responsibility for overseeing all aspects of cutoff testing, controlled equipment, and design verification, planning, protocols, testing, and reporting for various projects.• Provide dynamic, high-quality leadership to a top-performing team ranging in size from two to eight direct reports.• Serve as a Principal Investigator for key projects tasked with supporting validation protocols and testing.• Leverage knowledge of the design control process to develop a new immunoassay inclusive of EU IVDD approval; act as a member of IVDR teams for multiple initiatives.• Manage and maintain a robust sample bank repository containing thousands of samples.• Navigate complex challenges, issues, and obstacles with an innovative and solution-focused mindset.• Advocate for and uphold a safety-focused laboratory culture to ensure staff wellbeing and research integrity.• Draft and prepare detailed technical documentation and reports for leadership, recordkeeping, and compliance.• Drive continuous improvement by identifying process inefficiencies and implementing streamlined solutions.• Analyze and maintain knowledge of current and emerging industry trends, research, and innovations. Show less • Spearhead the development, growth, and leadership of the R&D Multiplexing Assay group from the ground up while serving as the multiplexing expert within a biotechnology start-up environment.• Demonstrate exceptional attention to detail and quality while preparing and performing hundreds of multiplexing assays using thousands of diverse samples, including troubleshooting assays, selecting protein markers, grouping biomarkers into multiplex assay systems, and transitioning research assays to the product development team for NephroCheck™.• Implemented hundreds of protein targets into multiplexing collection; increased protein marker coverage by designing custom multiplex kits using raw antibody/antigen materials for sample measurements in multiple disease areas.• Strengthen efficiency by effectively overseeing the work of fellow scientists and developing work schedules.• Perform data analysis and utilize Luminex, MSD, and ELISA for assay development and high throughput screening.• Chart the successful development and implementation of immunoassays and research lab procedures and methods.• Entrusted with serving as Project Manager responsible for screening hundreds of protein assays to measure clinical samples, resulting in the creation of 3M+ data points.• Foster collaborative working relationships with cross-functional teams while overseeing up to five direct reports.• Facilitate the development of other assays via lateral flow methods inclusive of striping, assembly, and testing. Show less

  • Senior Manager Lab Operations

    Jun 2022 - Oct 2023

  • Principal Scientist

    Apr 2018 - Oct 2023